Using aspirin to reduce postpartum heart issues in women with preeclampsia

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of aspirin therapy on postpartum cardiac function in women diagnosed with preeclampsia. It is a single-center, double-blind, randomized, placebo-controlled trial that focuses on patients with elevated Activin A levels, which are associated with increased risk of cardiac dysfunction. Participants will undergo blood tests to measure Activin A levels and will be randomized to receive either aspirin or a placebo after delivery. The goal is to determine if aspirin can effectively lower Activin A levels and improve cardiac function in this high-risk population.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Pregnant Adults between 18 and 45 years of age
2. Diagnosed with preeclampsia
3. Presenting for delivery with a singleton gestation.

Exclusion Criteria:

1. We will exclude patients in labor
2. Patients with preexisting cardiomyopathy, chronic hypertension, ischemic or valvular heart disease, pulmonary disease, diabetes mellitus, chronic kidney disease, multiple gestation
3. Plan to deliver outside of the participating site
4. Co-enrolled in other trials that might affect the patients taking the study medication, as determined by the PI.
5. Aspirin allergy
6. Clear indication for aspirin therapy or contraindication to aspirin therapy
7. Clinically significant conditions that might limit adherence to trial regimen (e.g., peptic ulcer disease, history of gastrointestinal bleeds, bleeding disorders)
8. Currently or planning on taking any nonsteroidal anti-inflammatory drugs while they are participating in this study.
9. Those who cannot provide consent

Where it's running

• University of Chicago Hospital
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Sajid Shahul, MD, PhD
• Email: sshahul1@dacc.uchicago.edu
• Phone: 773-398-2956

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Postpartum Preeclampsia Care Using Point-of-Care Ultrasound and Diuretics

  The study tests whether using bedside ultrasound to guide diuretic therapy can improve outcomes for adults with preeclampsia after delivery.

  Recruiting Phase 4 University of California, Irvine · Orange, California · NCT07167862

• Effects of high-salt intake on women after preeclampsia

  This study is testing how eating a lot of salt affects blood vessel health in women who had preeclampsia during pregnancy, to see if a medication can help improve their condition.

  Recruiting Early Phase 1 University of Iowa · Iowa City, Iowa · NCT06749418

• Using aspirin to help women recover from severe preeclampsia after childbirth

  This study tests if taking low-dose aspirin for a week after childbirth can help women recover faster from severe preeclampsia.

  Recruiting Phase 2 MemorialCare Health System · Long Beach, California · NCT05924971

• Low-dose aspirin for women with severe preeclampsia after delivery

  This study is testing if giving low-dose aspirin to women with severe preeclampsia after childbirth can help improve their blood vessel function and make their condition better.

  Recruiting Phase 2 Columbia University · New York, New York · NCT03667326

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.