Potassium citrate effects on kidney handling of oxalate and citrate in adults

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

At the University of Chicago Clinical Research Center, investigators will enroll two groups of 12 adults each: people with a history of calcium oxalate kidney stones and people without stones and with normal 24‑hour urine oxalate. Participants will receive a single oral dose of potassium citrate and have blood and urine collected over six hours to measure fractional excretion of oxalate and citrate. Changes from baseline will be compared and oxalate fractional excretion will be adjusted for changes in citrate to test a possible transporter-mediated link between the two ions. Key exclusions include non–calcium stone types, significant chronic kidney disease (eGFR <75 mL/min/1.73 m²), extreme urine citrate values, and inability to stop diuretics or alkali supplements.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Stone formers (SF):

* Age 18-70
* History of at least one calcium-based kidney stone

Non-stone formers (NSF):

* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within laboratory normal range (\<50 mg/day)

Exclusion Criteria:

History of primarily uric acid, cysteine, or struvite stones

History of severe acid-base abnormality, very low (less than 100 mg/day) or very high (greater than 1500 mg/day) urine citrate

Any controls or stone former (SF) participants who cannot stop diuretic medication or alkali supplementation for the course of the study period

Chronic kidney disease (glomerular filtration rate \<75 milliliters per minute per 1.73 square meters \[mL/min/1.73 m²\])

Non-stone formers (NSF) and stone formers (SF) with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Where it's running

• University of Chicago Medical Center
  Chicago, Illinois, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.