Exploring the link between kidney stones, insulin resistance, and inflammation
Official title: Inflammation and Insulin Resistance in Kidney Stone Patients
Run by University of Chicago · NCT06436235 · Data updated 2026-11-12
This study is trying to see if people with kidney stones have more belly fat and inflammation compared to healthy individuals, to better understand how these factors are linked.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 40 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | June 30, 2024 |
| Main results expected | July 1, 2028 |
| Study ends | August 1, 2028 |
| Registry record updated | July 8, 2026 |
| Trial ID | NCT06436235 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 18-70 with a history of calcium-based kidney stones or healthy individuals without such a history.
✕Probably not a fit
Patients with a history of diabetes, uric acid stones, or those on medications affecting urine composition may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study investigates the relationship between kidney stones, insulin resistance, and inflammation by comparing individuals with a history of calcium kidney stones to healthy controls. The study will recruit 40 participants, including 20 stone formers and 20 healthy individuals, who will undergo various assessments including DEXA scans, blood and urine sample analyses, and anthropometric measurements. Researchers aim to determine if those with kidney stones and insulin resistance exhibit higher levels of visceral fat and inflammation. The findings could provide insights into the metabolic factors associated with kidney stone formation.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the metabolic factors contributing to kidney stone formation, potentially leading to better prevention strategies.
How similar studies have gone: While the specific connections being explored are novel, previous studies have indicated links between metabolic factors and kidney stone formation.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stone formers: * Age 18-70 * History of at least one calcium-based kidney stone * Healthy Controls: * Age 18-70 * No history of kidney stone or family history of kidney stones Exclusion Criteria (for both groups): * History of primarily uric acid * Cysteine, or struvite stones * History of diabetes or impaired glucose tolerance * Previous thiazide use * Anyone on a medication that cannot be stopped that may affect urine composition * Previous bariatric surgery or ileostomy * Primary hyperparathyroidism and elevated serum calcium.
Where it's running
-
University of Chicago Medical Center
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Megan Prochaska, MD — University of Chicago
- Study coordinator: Megan Prochaska, MD
- Email: mprocha2@medicine.bsd.uchicago.edu
- Phone: 773-702-1000
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Emergency urinary drainage followed by PCNL in obstructive urosepsis
Doctors test whether the method of emergency drainage (retrograde ureteral stent or percutaneous nephrostomy) affects how well patients do after undergoing definitive PCNL.
-
Observation vs Upfront Surgery for Asymptomatic Kidney Stones in Children and Adults
This trial tests whether watching asymptomatic kidney stones or performing upfront surgery is better for reducing life disruption in patients aged 6 and older.
-
Two-Tier Virtual Reality Education to Reduce Anxiety Before Kidney Stone Surgery
This study tests whether a two-tier VR preoperative education approach can lower anxiety and improve knowledge and self-care in adults undergoing urolithiasis surgery.
-
Tamsulosin 0.4 mg with Tadalafil 5 mg versus 2.5 mg to reduce symptoms from ureteral stents
This will test whether adding Tadalafil at 5 mg or 2.5 mg to Tamsulosin 0.4 mg better reduces stent-related symptoms for adults with a double-J ureteral stent after stone removal.
-
Mini‑PCNL versus flexible ureteroscopy with a suction sheath for 2–3 cm kidney stones
This tests whether mini‑PCNL or flexible ureteroscopy with a suction sheath better clears 2–3 cm kidney stones and leads to fewer complications in adults.
-
Ureteral access sheath: omitting versus placing a stent after ureteroscopy
We will test if leaving out a ureteral stent after ureteroscopy with an access sheath works as well as placing a stent for pre-stented adults with kidney or ureteral stones.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.