Exploring the link between kidney stones, insulin resistance, and inflammation
Inflammation and Insulin Resistance in Kidney Stone Patients
This study is trying to see if people with kidney stones have more belly fat and inflammation compared to healthy individuals, to better understand how these factors are linked.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 40 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06436235 on ClinicalTrials.gov |
What this trial studies
This observational study investigates the relationship between kidney stones, insulin resistance, and inflammation by comparing individuals with a history of calcium kidney stones to healthy controls. The study will recruit 40 participants, including 20 stone formers and 20 healthy individuals, who will undergo various assessments including DEXA scans, blood and urine sample analyses, and anthropometric measurements. Researchers aim to determine if those with kidney stones and insulin resistance exhibit higher levels of visceral fat and inflammation. The findings could provide insights into the metabolic factors associated with kidney stone formation.
Who should consider this trial
Good fit: Ideal candidates include adults aged 18-70 with a history of calcium-based kidney stones or healthy individuals without such a history.
Not a fit: Patients with a history of diabetes, uric acid stones, or those on medications affecting urine composition may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could enhance understanding of the metabolic factors contributing to kidney stone formation, potentially leading to better prevention strategies.
How similar studies have performed: While the specific connections being explored are novel, previous studies have indicated links between metabolic factors and kidney stone formation.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Stone formers: * Age 18-70 * History of at least one calcium-based kidney stone * Healthy Controls: * Age 18-70 * No history of kidney stone or family history of kidney stones Exclusion Criteria (for both groups): * History of primarily uric acid * Cysteine, or struvite stones * History of diabetes or impaired glucose tolerance * Previous thiazide use * Anyone on a medication that cannot be stopped that may affect urine composition * Previous bariatric surgery or ileostomy * Primary hyperparathyroidism and elevated serum calcium.
Where this trial is running
Chicago, Illinois
- University of Chicago Medical Center — Chicago, Illinois, United States (Recruiting)
Study contacts
- Principal investigator: Megan Prochaska, MD — University of Chicago
- Study coordinator: Megan Prochaska, MD
- Email: mprocha2@medicine.bsd.uchicago.edu
- Phone: 773-702-1000
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.