Understanding how oxalate affects kidney stone formation in bariatric surgery candidates

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the relationship between dietary oxalate and the formation of kidney stones in individuals who have undergone Roux-en-Y gastric bypass surgery, as well as in obese and non-obese stone formers. Participants will follow a low-oxalate diet for three days, after which they will undergo a specialized oral load test to measure oxalate absorption. The study aims to collect urine samples to analyze oxalate levels and understand how oxalate is absorbed in the gastrointestinal tract. The research is conducted at the University of Chicago, utilizing their Clinical Research Center.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Post-Roux-en-Y gastric bypass stone formers:

* Age 18-70
* Previous history of Roux-en-Y gastric bypass
* History of at least one calcium-based kidney stone after surgery
* Pre-protocol urine oxalate above the lab normal range (50mg/day)

Obese stone formers:

* Age 18-70
* Body mass index (BMI) \>=30kg/m2
* History of at least one calcium-based kidney stone
* Pre-protocol urine oxalate above the lab normal range (50mg/day)

Non-obese stone formers:

* Age 18-70, BMI between 18.5-29.9 kg/m2
* History of at least one calcium-based kidney stone

Exclusion Criteria:

Post-Roux-en-Y gastric bypass stone formers:

* History of colon resection (partial or complete)
* History of duodenal switch bowel surgery
* History of ileal-jejunal bypass surgery
* History of primarily uric acid, cysteine, or struvite stones

Obese and non-obese stone formers:

* History of bowel surgery
* History of colon resection
* History of inflammatory bowel disease (Crohn's disease, Ulcerative Colitis)
* History of primarily uric acid, cysteine, or struvite stones

Where it's running

• University of Chicago Medical Center
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Megan Prochaska, MD
• Email: mprocha2@medicine.bsd.uchicago.edu
• Phone: 773-702-1000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.