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Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Routine screening and support for emotional health in adults with type 2 diabetes

Official title: ARISE: Achieving Routine Intervention and Screening for Emotional Health: Randomized Controlled Trial

Run by University of Chicago · NCT06887049 · Data updated 2026-11-12

This project will test whether routine screening for diabetes-related emotional distress plus brief clinic training helps adults with type 2 diabetes and A1C over 8% feel less distressed and manage their diabetes better.

More Type 2 Diabetes Mellitus (T2DM) trials

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment880 (estimated)
SponsorUniversity of Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedMarch 10, 2026
Main results expectedOctober 2027
Study endsOctober 2028
Registry record updatedOctober 21, 2026
Trial IDNCT06887049 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are adults (18+) with type 2 diabetes who receive care at a participating clinic and have an A1C above 8% and are not pregnant.

Probably not a fit

Patients who are pregnant, have type 1 diabetes, have A1C ≤ 8%, or do not receive care at a participating clinic are unlikely to benefit from this program.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Patients at participating University of Chicago clinics with type 2 diabetes and A1C > 8% will be screened for diabetes distress using a standardized instrument. Clinics will implement the ARISE Learning Community diabetes distress screening and intervention or receive an ARISE Enhanced Care brief training to help clinicians address distress. Outcomes include changes in diabetes distress scores, self-care behaviors, and clinical measures such as A1C. The project emphasizes improving detection and treatment of diabetes-related emotional burden, particularly in populations with higher prevalence of distress.

Why it matters

Potential benefit: If successful, routine screening combined with targeted clinic support could lower diabetes-related distress, improve self-care, and modestly improve blood sugar control.

How similar studies have gone: Previous studies have used standardized diabetes distress screening and some intervention trials have shown reductions in distress, although routine screening is not yet widely implemented.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patient at a participating clinic
* Type 2 diabetes
* Adult (18 years or older)
* A1C \> 8%
* English- or Spanish-speaking

Exclusion Criteria:

* Pregnant

Where it's running

  • University of Chicago
    Chicago, Illinois, United States     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Type 2 Diabetes Mellitus (T2DM) 68Diabetes Distress 7University of Chicago 1046
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.