Effects of oxalate and citrate on kidney stone formation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how dietary oxalate and citrate influence the likelihood of forming kidney stones. Participants will consume a special drink containing sodium oxalate, and researchers will measure the fractional excretion of oxalate and citrate in urine. The goal is to determine whether the relationship between these compounds is primarily dietary or influenced by other factors. The findings could inform dietary recommendations for kidney stone prevention and guide future research on alkali supplementation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

Stone formers:

* Age 18-70
* History of at least one calcium-based kidney stone

Non-stone formers (controls):

* Age 18-70
* No history of kidney stone
* 24-hour urine oxalate within lab normal (\<50mg/day)

Exclusion Criteria:

* History of primarily uric acid, cysteine, or struvite stones.
* History of severe acid-base abnormality, very low (less than 100mg/day) or very high (greater than 1500mg/day) urine citrate.
* Any controls or stone-forming participants who cannot stop diuretic medication or alkali supplementation for the course of the study period.
* Non-stone formers and stone-formers with extreme levels of urine citrate will be excluded from this small initial study to reduce heterogeneity and remove focus from the extremes of citrate levels.

Where it's running

• University of Chicago Medical Center
  Chicago, Illinois, United States Recruiting

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.