Gut microbiome and metabolomics after stereotactic radiosurgery
Official title: Microbiome Determinants of Adverse Effects of Stereotactic Radiosurgery
Run by University of Chicago · NCT07767981 · Data updated 2026-11-12
This study will see if the gut microbiome and blood metabolites change after stereotactic radiosurgery and whether those changes relate to adverse effects like radiation necrosis.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Drugs / interventions | radiation |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | August 5, 2025 |
| Main results expected | August 5, 2027 |
| Study ends | September 5, 2028 |
| Registry record updated | August 18, 2026 |
| Trial ID | NCT07767981 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults undergoing stereotactic radiosurgery at the University of Chicago who can provide informed consent.
✕Probably not a fit
Patients unlikely to benefit are those who do not develop adverse effects or who do not show microbiome/metabolite associations despite participation.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This prospective observational study follows patients receiving stereotactic radiosurgery as part of standard care, collecting stool and blood samples before treatment and during follow-up. It will profile gut microbiome composition and metabolite patterns over time and compare these with clinical outcomes such as radiation necrosis and other adverse radiation effects. Researchers will also integrate longitudinal imaging and clinical data to explore associations between microbial/metabolite features and adverse events. The goal is to identify potential microbiome-related indicators that could help predict or understand these side effects.
Why it matters
Potential benefit: If successful, findings could help predict which patients are at higher risk for adverse effects based on microbiome or metabolite profiles and guide future interventions.
How similar studies have gone: Prior work has begun to link microbiome profiles with treatment-related toxicities in other radiotherapy settings, but this exact SRS and gut-metabolite focus is exploratory.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Admitted to the University of Chicago Medical Center * Receiving stereotactic radiosurgery as standard of care for their presumed diagnosis * Able to provide informed consent Exclusion Criteria: * Anticipated survival of less than 6 months * Known or suspected infectious colitis within the month prior to enrollment * Rectal disease that prevents fecal sampling * Foreseeable inability to complete the study
Where it's running
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University of Chicago
Chicago, Illinois, United States Recruiting
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.