Transition Support for First-Episode Psychosis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study tests a Transition Care Team that starts work while patients are in the hospital and continues after discharge to coordinate therapy, case management, and connections to community services. The goal is to see if this approach increases the share of patients who begin outpatient psychiatric treatment after hospitalization and whether it improves symptoms and functioning. The program reflects a Coordinated Specialty Care model aimed at early, continuous engagement during a vulnerable care-transition period. Researchers will compare outcomes to standard discharge practices and assess safety, feasibility, and patient well-being.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of schizophrenia, schizoaffective disorder, bipolar disorder with psychotic features, major depressive disorder with psychotic features, schizophreniform disorder, or psychosis NOS
* The diagnosis of one of the psychotic disorders has a duration of less than two years.
* Able to read, speak, and understand English, which will be assessed through observation.
* Able and willing to provide written informed consent or assent, in cases where caregivers are considered legal guardians. Dr. Shima, co-I of the study, is a forensic psychiatrist, and particularly adept at judging such ability. Drs. Erickson and Keedy have conducted studies in individuals with psychotic disorders, including FEP and in the context of clinical trials, for years, and are similarly competent to judge whether individuals can provide informed consent. Finally, we will also use an Evaluation to Sign Consent form that documents subjects' verbalized understanding of key aspects of the study.
* have an estimated IQ of \> 65, assessed by the Wechsler Test of Adult Reading
* Eligible caregivers/proxy informants must be identified by the participant or clinical team as being involved in the participant's discharge planning or follow-up care, be able to provide informed verbal consent, and be able to speak and read English sufficiently to complete study questionnaires. Caregivers may include family members, close supports, or legally authorized representatives.

Exclusion Criteria:

* Individuals with substance-induced psychosis or psychosis due to a medical condition will not be included in the study. We will use the Structured Clinical Interview for DSM-5 as well as medical records, and if the subject gives permission, caregiver information in this process
* Individuals who do not meet criteria for a first episode of psychosis

Where it's running

• University of Chicago Ingalls Memorial Hospital
  Harvey, Illinois, United States Recruiting
• University of Chicago Medical Center, Biological Science Division
  Chicago, Illinois, United States Active not recruiting

Study contacts

• Principal investigator: Molly Erickson, PhD — University of Chicago
• Study coordinator: Madeline Perez Lab Manager, B.S
• Email: keedylab@gmail.com
• Phone: 773-712-9178

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.