Using bupivacaine to reduce pain after ureteroscopy for kidney stones

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the effectiveness of instilling bupivacaine in the bladder after ureteroscopy, a procedure for treating kidney stones. It is a randomized trial comparing the effects of bupivacaine against a placebo (normal saline) on post-operative pain and urinary symptoms. The hypothesis is that bupivacaine will lead to reduced pain and improved quality of life in patients following the procedure. Participants will be monitored for their pain levels and urinary symptoms in the early post-operative period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Provision of signed and dated informed consent form
* Stated willingness to comply with all study procedures and availability for the duration of the study.
* Male or female, aged ≥ 18 years old.
* Diagnosis of nephrolithiasis planned for flexible or semi-rigid ureteroscopy in the treatment of stone disease with ureteral stenting.

Exclusion Criteria:

* Foley catheterization
* History of allergy to bupivacaine
* Antegrade ureteroscopy
* Transplant or ectopic kidney
* Ureteral or bladder reconstruction
* Pregnancy (which is a contraindication to elective ureteroscopy)
* Dialysis
* Surgical complication (significant bleeding, ureteral perforation, significant urothelial damage)
* Suspicion of untreated urinary tract infection
* History of pelvic radiation
* Neurologic disease with a diagnosis of neurogenic bladder dysfunction
* History of chronic pain (fibromyalgia, interstitial cystitis, opioid abuse)

Where it's running

• The University of Chicago Medical Center
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Luke Reynolds, MD — University of Chicago
• Study coordinator: Luke Reynolds, MD
• Email: lukereynolds@bsd.uchicago.edu
• Phone: 7137926105

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.