Investigating gut bacteria in critically ill patients
Pathobiomes in Gut of Critically Ill Patients
University of Chicago · NCT06822465
This study looks at how a specific gut bacteria called Pseudomonas aeruginosa affects critically ill surgical patients to see if it plays a role in their health and survival.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 100 (estimated) |
| Ages | 18 Years to 85 Years |
| Sex | All |
| Sponsor | University of Chicago (other) |
| Locations | 1 site (Hyde Park, Illinois) |
| Trial ID | NCT06822465 on ClinicalTrials.gov |
What this trial studies
This observational study examines the presence of Pseudomonas aeruginosa in the intestines of critically ill surgical patients, who are at high risk for severe infections and multi-organ failure. It aims to understand how this bacterium interacts with the host's stress responses and contributes to increased mortality rates. By analyzing gut microbiomes and their effects on patient health, the study seeks to uncover mechanisms behind gut-derived sepsis. The research involves both in vitro and in vivo assays to assess the virulence of P. aeruginosa in the context of critical illness.
Who should consider this trial
Good fit: Ideal candidates for this study are critically ill surgical patients aged 18 to 85 years.
Not a fit: Patients with a known history of HIV/AIDS, those who are pregnant, or incarcerated individuals may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved understanding and management of infections in critically ill patients, potentially reducing mortality rates.
How similar studies have performed: While the specific approach of this study may be novel, similar studies investigating gut microbiomes in critically ill patients have shown promising results in understanding infection mechanisms.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Any ethnicity * Age \> 18 years and \< 85 years Exclusion Criteria: * A known history of HIV/AIDS * Active pregnancy * Are incarcerated will be excluded from the study.
Where this trial is running
Hyde Park, Illinois
- The University of Chicago — Hyde Park, Illinois, United States (RECRUITING)
Study contacts
- Principal investigator: John Alverdy, MD FACS FSIS — University of Chicago
- Study coordinator: John Alverdy, MD FACS FSIS
- Email: jalverdy@bsd.uchicago.edu
- Phone: 773-702-4876
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Pseudomonas Aeruginosa