Using pharmacogenomic information to improve warfarin dosing in African American patients
Official title: Implementation of Point-of-Care Pharmacogenomic Decision Support Accounting for Minority Disparities
Run by University of Chicago · NCT03225820 · Data updated 2026-11-12
This study is testing if using genetic information can help doctors give the right dose of warfarin to African American patients in the hospital to improve their health outcomes.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 2 sites (Chicago, Illinois and 1 other locations) |
| Status | Recruiting |
| Started | November 9, 2017 |
| Main results expected | March 2028 |
| Study ends | March 2028 |
| Registry record updated | April 24, 2026 |
| Trial ID | NCT03225820 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are African American adults aged 18 and older who are likely to initiate warfarin therapy.
✕Probably not a fit
Patients with liver or kidney transplantation considerations, active leukemia, or those unable to provide informed consent may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study explores the feasibility of delivering pharmacogenomic results at the point-of-care in inpatient settings, focusing on African American patients who may face health disparities. It aims to determine if providing pharmacogenomic-based dosing guidance for warfarin can enhance clinical outcomes. Patients will be consented and genotyped for actionable variants predicting drug response or toxicity risk during their hospital stay. The study will involve multiple institutions, including The University of Chicago, University of Illinois at Chicago, and Northwestern University.
Why it matters
Potential benefit: If successful, this approach could lead to improved warfarin dosing and better health outcomes for African American patients.
How similar studies have gone: Other studies have shown promise in using pharmacogenomic information to improve medication management, but this specific approach focusing on minority disparities is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patients must be at least 18 years of age. * Patients must self-identify as African American Exclusion Criteria: * Patients who have undergone, or are being actively considered for, liver or kidney transplantation. * Patients with known active or prior leukemia. * Inability to understand and give informed consent to participate. * For patients being recruited to the warfarin sub-study, those with a glomerular filtration rate or creatinine clearance \<30 mL/min34.
Where it's running
-
The University of Illinois at Chicago
Chicago, Illinois, United States Recruiting -
Northwestern University
Chicago, Illinois, United States Not yet recruiting
Study contacts
- Principal investigator: Peter O'Donnell, MD — University of Chicago
- Study coordinator: Cancer Clinical Trials Office
- Email: cancerclinicaltrials@bsd.uchicago.edu
- Phone: 1-855-702-8222
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.