Assessing diabetes risk in cirrhosis patients before and after liver transplant

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to identify risk factors for developing diabetes in adult patients with cirrhosis who are being evaluated for liver transplantation. Participants will undergo various assessments, including continuous glucose monitoring, wrist actigraphy, and oral glucose tolerance tests, both prior to and following their liver transplant. The study will track these patients over a five-year period to evaluate the long-term outcomes related to diabetes development. The goal is to determine if specific laboratory and functional tests can predict the onset of diabetes after transplantation.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients presenting to liver transplant clinic with a diagnosis of cirrhosis.
* Age \>18 yrs.
* Ability to understand and sign written consent form, or have a legally-authorized representative or proxy who can be approached for consent

Exclusion Criteria:

* Patients without consent
* Patients with implantable cardioverter defibrillator devices or automated implantable cardioverter defibrillator devices will be excluded from the bio-electrical impedance analysis portion of the measurements.
* Patients with unremovable electrical medical devices or devices that cannot turn off will be excluded from the bio-electrical impedance analysis measurements
* Pregnant patients
* Incarcerated patients
* Patients with a history of type 2 diabetes mellitus diagnosed \> 5 years ago will be excluded from the Oral Glucose Tolerance Test portion of the study

Where it's running

• University of Chicago Medical Center
  Chicago, Illinois, United States Recruiting

Study contacts

• Principal investigator: Alan L Hutchison, MD PhD — University of Chicago
• Study coordinator: Alan L Hutchison, MD PhD
• Email: Alan.Hutchison@uchicagomedicine.org
• Phone: 773-702-1000

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.