Total IV anesthesia vs spinal anesthesia for same-day discharge after knee replacement
Official title: Total Intravenous Anesthesia vs Spinal Anesthesia in Patients Undergoing Unilateral Primary Total Knee Arthroplasty
Run by University of Chicago · NCT07672301 · Data updated 2026-11-12
This study tests whether using total intravenous anesthesia (TIVA) or spinal anesthesia helps adults have same-day discharge after a primary total knee replacement.
Quick facts
| Phase | Phase1; Phase2 |
|---|---|
| Study type | Interventional |
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 150 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | March 11, 2026 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | June 26, 2026 |
| Trial ID | NCT07672301 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults ≥18 years scheduled for elective primary TKA at University of Chicago and eligible for same-day discharge, who consent to randomization between TIVA and spinal anesthesia.
✕Probably not a fit
Patients who can't experience same-day discharge or have contraindications to either anesthesia technique may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Adults undergoing elective primary total knee arthroplasty are randomized to receive either TIVA or spinal anesthesia. The trial looks at same-day discharge rates and recovery in the PACU, with secondary measures including cognition, hemodynamics, pain, nausea, and intraoperative EEG metrics, aiming to understand how anesthesia choice affects recovery and safety. Processed EEG guidance may be used to optimize depth of anesthesia. Long-term follow-up and safety outcomes, including readmission and adverse events, are also tracked in a neutral, rigorous manner.
Why it matters
Potential benefit: If successful, the findings could inform anesthesia choices to improve same-day discharge rates and recovery after TKA.
How similar studies have gone: Previous work has explored different anesthesia techniques in TKA, with some showing benefits for recovery and postoperative outcomes, though direct head-to-head comparison with same-day discharge focus is evolving.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Adults aged ≥18 years. * Scheduled to undergo elective primary total knee arthroplasty (TKA) or robotic total knee arthroplasty (TKA) at the University of Chicago. * Eligible for same-day discharge (SDD) based on established orthopedic and anesthesia criteria. * Able to provide written informed consent. * The ability to comprehend and complete cognitive assessment surveys and questionnaires. * Consent to receive either Total IntraVenous Anesthesia (TIVA) or Spinal-block Anesthesia in a randomized manner * No contraindication to either TIVA or spinal anesthesia Exclusion Criteria: * Age \<18 years. * Patients undergoing revision TKA or procedures other than elective primary TKA. * Ineligibility for same-day discharge as determined by the surgical or anesthesia team. * Contraindications to either anesthetic technique (e.g., spinal block anesthesia contraindicated due to coagulopathy, infection at puncture site, or patient refusal). * Known allergy or hypersensitivity to study-related medications. * Significant pre-existing cognitive impairment or dementia that would preclude valid participation in Short Portable Mental Status Questionnaire (SPMSQ), and 3-Minute Diagnostic Assessment for Confusion Assessment Method (3D-CAM) assessments. * Severe chronic pain syndromes (e.g., fibromyalgia, centrally mediated pain disorders) that could confound perioperative pain assessment. * Body mass index (BMI) \> 40. * Prisoners or other vulnerable populations unable to provide voluntary consent. * Unable to give appropriate consent or difficult to comprehend and complete cognitive assessment surveys and questionnaires
Where it's running
-
University of Chicago Medical Center
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Zheng Xie, MD, PhD — University of Chicago, Department of Anesthesia and Critical Care
- Study coordinator: Frank T Brown Jr, MA
- Email: ftbrownjr@uchicagomedicine.org
- Phone: 773-834-5778
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.