PMOS and Sleep Apnea: A Pilot Look at Mitochondrial Function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot interventional study examines how obstructive sleep apnea affects cellular metabolism in PMOS by measuring mitochondrial function in skeletal muscle. Participants will have CPAP therapy applied to assess changes in muscle bioenergetics using high resolution respirometry on muscle biopsies taken with and without CPAP. The study focuses on women aged 18-40 with PMOS and a diagnosed sleep apnea, aiming to generate early data on metabolic responses to CPAP in this multi-systemic condition. Outcomes will inform whether treating sleep apnea could impact the metabolic aspects of PMOS.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Women 18-40 years old
* PMOS diagnosis
* Sleep Apnea (AHI\>5) diagnosed by home sleep test (WatchPAT One)
* BMI\< 50.0

Exclusion Criteria:

* Regular adherent CPAP use per clinical guidelines
* Any history of bleeding disorders
* Current use of anti-coagulant medication
* Hemoglobin \<11.6 g/dL
* Currently pregnant, pregnant within the last year, or gave birth within the last year
* Any underlying disease likely to limit life span and/or increase risk of interventions including cardiovascular disease (e.g. unstable angina, heart failure requiring hospitalization in the past 6 months, significant heart block or arrhythmias, NYHA Class\>2), pulmonary disease with dependence on oxygen or daily use of bronchodilators, cancer requiring treatment in the past 5 years unless the prognosis is considered good, active or chronic infection, thyroid disease and other endocrine disorders (e.g. Cushing syndrome, acromegaly), hepatitis or other chronic gastrointestinal disease (pancreatitis, inflammatory bowel disease), renal disease, significant anemia, recent surgery or significant abdominal surgery, major psychiatric or any eating disorder, acute coronary syndrome or stroke in the past 6 months

Where it's running

• University of Chicago
  Chicago, Illinois, United States Recruiting

Study contacts

• Study coordinator: Bonnie Olivia Hughes
• Email: bhughes8@bsd.uchicago.edu
• Phone: 773-834-7809

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.