Outcomes after immediate lymphatic reconstruction
Official title: Prospective Assessments Following Immediate Lymphatic Reconstruction
Run by University of Chicago · NCT07227467 · Data updated 2026-11-12
This protocol will follow people having immediate lymphatic reconstruction during lymph node surgery to see if the procedure prevents lymphedema.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | University of Chicago Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | March 1, 2026 |
| Main results expected | December 2030 |
| Study ends | December 2030 |
| Registry record updated | October 13, 2026 |
| Trial ID | NCT07227467 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are people scheduled for lymph node dissection who are judged preoperatively to be eligible for ILR based on possible nodal involvement.
✕Probably not a fit
Patients who are not eligible for ILR based on their preoperative nodal assessment will not be able to participate and therefore will not receive potential benefit from this protocol.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
Immediate lymphatic reconstruction (ILR) is a microsurgical technique performed at the time of lymph node dissection that connects transected lymphatic channels to nearby veins to redirect lymph drainage. This prospective observational protocol at the University of Chicago will enroll patients deemed candidates for ILR and collect standardized clinical and surgical data over time. Follow-up visits will document limb swelling, complications, and functional outcomes to determine real-world rates of post-operative lymphedema. As a single-center effort at a high-volume microsurgery program, the project aims to add systematic outcome data where randomized evidence is currently limited.
Why it matters
Potential benefit: If successful, ILR could lower the risk of arm lymphedema after lymph node dissection and improve long-term arm function and quality of life.
How similar studies have gone: Early single-center reports, including Chang et al. 2020, report promising reductions in lymphedema with ILR, but randomized and multi-center confirmation is lacking.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: potential candidates for ILR based on possible nodal involvement assessed preoperatively. Exclusion Criteria: * Individuals who are not eligible for ILR based on possible nodal involvement assessed preoperatively.
Where it's running
-
The University o Chicago
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Summer Hanson, MD, PhD, FACS — University of Chicago
- Study coordinator: Summer Hanson, MD, PhD, FACS
- Email: sehanson@bsd.uchicago.edu
- Phone: (773) 702-6302
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.