Clinical trial Recruiting at 1 site Observational Ages 18 and up

Outcomes after immediate lymphatic reconstruction

Official title: Prospective Assessments Following Immediate Lymphatic Reconstruction

Run by University of Chicago · NCT07227467 · Data updated 2026-11-12

This protocol will follow people having immediate lymphatic reconstruction during lymph node surgery to see if the procedure prevents lymphedema.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorUniversity of Chicago
Academic / other
Locations1 site (Chicago, Illinois)
StatusRecruiting
StartedMarch 1, 2026
Main results expectedDecember 2030
Study endsDecember 2030
Registry record updatedOctober 13, 2026
Trial IDNCT07227467 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are people scheduled for lymph node dissection who are judged preoperatively to be eligible for ILR based on possible nodal involvement.

Probably not a fit

Patients who are not eligible for ILR based on their preoperative nodal assessment will not be able to participate and therefore will not receive potential benefit from this protocol.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

Immediate lymphatic reconstruction (ILR) is a microsurgical technique performed at the time of lymph node dissection that connects transected lymphatic channels to nearby veins to redirect lymph drainage. This prospective observational protocol at the University of Chicago will enroll patients deemed candidates for ILR and collect standardized clinical and surgical data over time. Follow-up visits will document limb swelling, complications, and functional outcomes to determine real-world rates of post-operative lymphedema. As a single-center effort at a high-volume microsurgery program, the project aims to add systematic outcome data where randomized evidence is currently limited.

Why it matters

Potential benefit: If successful, ILR could lower the risk of arm lymphedema after lymph node dissection and improve long-term arm function and quality of life.

How similar studies have gone: Early single-center reports, including Chang et al. 2020, report promising reductions in lymphedema with ILR, but randomized and multi-center confirmation is lacking.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

potential candidates for ILR based on possible nodal involvement assessed preoperatively.

Exclusion Criteria:

* Individuals who are not eligible for ILR based on possible nodal involvement assessed preoperatively.

Where it's running

  • The University o Chicago
    Chicago, Illinois, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.