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Clinical trials and research at Ohio State University

• 129Clinical trials
• 1162NIH research projects
• 2New in 30 days
• 2Countries

Newest trials

All recruiting trials (129)

• Arthrocentesis with ACL Reconstruction for Acute ACL Tears

  This trial tests whether draining the knee before and after ACL reconstruction helps reduce inflammation, prevent muscle loss, and speed recovery in people with a recent ACL tear.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT07929922

• Restoring Emotional Balance With Ketones for Women After Birth

  This study tests whether taking a ketone supplement plus group cognitive-behavioral counseling and guided exercise can help women within 12 months after birth who have postpartum depression feel better.

  Recruiting Ohio State University · Columbus, Ohio · NCT07919392

• Do dual-focus multifocal contact lenses improve hand-eye coordination and sports vision compared with your usual lenses

  This study tests whether wearing dual-focus multifocal contact lenses improves hand-eye coordination and sports vision in adults who play baseball or softball and normally wear contact lenses.

  Recruiting Ohio State University · Columbus, Ohio · NCT07840209

• New Generation Therapies for Suicide: Refining Brief Cognitive Behavioral Therapy

  This study tests different sequences and doses of Brief Cognitive Behavioral Therapy to see if it better reduces suicide risk in adults with recent suicidal thoughts or behavior.

  Recruiting Ohio State University · Columbus, Ohio · NCT07818889

• Anxiety Skills Study: See if video skill training plus therapy helps people with anxiety

  This study tests whether a brief video-based skill training can help people with anxiety as well as four therapy sessions, and how durable the effects are over a year.

  Recruiting Ohio State University · Columbus, Ohio · NCT07774481

• Restrained vs Gripping Wrist Restraints for Cesarean Delivery

  This study tests whether a soft wrist-level gripping restraint reduces anxiety for adults having an elective cesarean delivery under spinal or combined spinal-epidural anesthesia.

  Recruiting Ohio State University · Columbus, Ohio · NCT07772219

• Self-Supervised Constraint-Induced Movement Therapy for Stroke Recovery

  This study tests a partly self-guided therapy program to help adults recover the use of their weaker arm after stroke, aiming to require less time with a therapist.

  Recruiting Ohio State University · Columbus, Ohio · NCT07723300

• Using a device to check labor epidural catheters before tubal ligation

  This pilot study tests whether the CompuFlo CathCheck system can reliably tell if a labor epidural catheter is functioning before a postpartum tubal ligation.

  Recruiting Ohio State University · Columbus, Ohio · NCT07720908

• Aromatherapy and a wearable TENS device for chronic nausea in adults

  This study tests two inhaled essential oil products and a wearable TENS device to see how they relate to nausea and anxiety in adults with long-standing symptoms.

  Recruiting Ohio State University · Columbus, Ohio · NCT07720336

• Can a wearable TENS device reduce chronic nausea symptoms?

  This study tests whether the EmeTerm wearable TENS device can lessen nausea in adults with long-standing symptoms who are treated at Ohio State University.

  Recruiting Ohio State University · Columbus, Ohio · NCT07720323

• Online yoga for people with diabetic gastroparesis

  A virtual yoga program is being tried to see if it can help reduce gastroparesis symptoms and improve well‑being in people with diabetes.

  Recruiting Ohio State University · Columbus, Ohio · NCT07717554

• Virtual poetry workshops to boost well-being for people with digestive symptoms

  This study tests whether participating in online poetry workshops can improve emotional well-being for adults with chronic digestive symptoms and anxiety or depression.

  Recruiting Ohio State University · Columbus, Ohio · NCT07717541

• VisionWay Accessibility for People With Visual Impairments

  A mobile tool called VisionWay tests whether a live outside map can help people who are blind or visually impaired choose safe walking paths to a chosen destination.

  Recruiting at 2 sites Ohio State University · Orono, Maine and 1 other locations · NCT07713979

• Ketone Ester Effects on Brain Function in Healthy Adults

  In healthy middle-aged and older adults, this study will test whether a ketone ester drink changes brain activity, blood flow, and metabolism compared with a placebo.

  Recruiting Ohio State University · Columbus, Ohio · NCT07711990

• Lidocaine on the Endotracheal Tube to Try to Reduce Emergence Coughing

  We’re testing whether putting 5% lidocaine ointment on the outside of the tube before intubation helps adults wake up without coughing or bucking.

  Recruiting Early Phase 1 Ohio State University · Columbus, Ohio · NCT07709390

• Two EMG Monitors for Deep NMB During Robotic/Thoracic Surgery

  This study tests whether two quantitative EMG monitors (TetraGraph and TwitchView) can better maintain deep neuromuscular blockade during abdominal and thoracic surgery by comparing diaphragmatic movements and breath-initiation events in the same patient.

  Recruiting Ohio State University · Columbus, Ohio · NCT07706504

• Dural Puncture Epidural (DPE) Technique in Labor Analgesia

  This observational study at Ohio State tests whether the DPE method can reliably reveal CSF and improve epidural placement during labor without injecting medication.

  Recruiting Ohio State University · Columbus, Ohio · NCT07704554

• How GLP-1 meds affect resistance training in adults with obesity/diabetes

  This study tests whether adults taking a GLP-1 receptor agonist can better preserve or gain muscle when they do resistance training.

  Recruiting Ohio State University · Columbus, Ohio · NCT07702461

• Lidocaine Patch to Ease Pain of Epidural Placement During Labor

  This study tests whether a 4% lidocaine patch used before epidural placement helps reduce pain for laboring women who need neuraxial analgesia.

  Recruiting Phase 3 Ohio State University · Columbus, Ohio · NCT07700108

• Improving Uroflowmetry: Do Pre-Procedure Reminders Help Women Undergoing Urodynamics

  This study tests whether sending reminder calls before a urodynamics test helps women with pelvic floor disorders feel more prepared and less anxious, and whether it makes the procedure go more smoothly.

  Recruiting Ohio State University · Columbus, Ohio · NCT07692789

• Lower-extremity blood pressure monitoring during cesarean under spinal anesthesia

  This study tests whether noninvasive blood pressure monitoring from the toe is better than the arm at predicting neonatal outcomes during cesarean delivery with spinal anesthesia.

  Recruiting Ohio State University · Columbus, Ohio · NCT07685730

• Short-Term Intensive PTSD Treatment for Military Personnel

  This trial tests whether a brief, massed form of CPT and EMDR can quickly reduce PTSD symptoms and related cognitive problems in active-duty military personnel.

  Recruiting Ohio State University · Fayetteville, North Carolina · NCT07680517

• Force feedback in robotic lung resection: does gentler instrument touch help recovery?

  This study tests whether using Force Feedback instruments during robotic lobectomy or segmentectomy leads to faster recovery and fewer complications for adults undergoing these procedures.

  Recruiting Ohio State University · Columbus, Ohio · NCT07660900

• Fermented foods for bowel health in adults with spinal cord injury

  This study tests whether a diet rich in fermented foods improves bowel function and gut health in adults with chronic spinal cord injury.

  Recruiting Ohio State University · Columbus, Ohio · NCT07640152

• Blue vs red fixation training for light sensitivity after brain injury

  Researchers test whether daily 20-minute blue-light fixation training helps people with light sensitivity after traumatic brain injury more than red-light fixation training.

  Recruiting Ohio State University · Columbus, Ohio · NCT07606300

• Family-based therapy for women in specialty courts with opioid use and sex-trade involvement

  A pilot test will see if an adapted, family-focused therapy can be feasibly added to specialty-court programs for women who use opioids and have sex-trade involvement.

  Recruiting Ohio State University · Columbus, Ohio · NCT07587359

• Delay nearsightedness in high-risk children with nightly low-dose eye drops

  This will test whether giving children ages 6–11 nightly 0.05% atropine eye drops delays the start of nearsightedness compared with nightly placebo drops.

  Recruiting at 12 sites Phase 3 Ohio State University · Birmingham, Alabama and 12 other locations · NCT07567040

• NOURISH: a community partnership to improve nutrition and glycemic control in pregnant women with pregestational diabetes

  Aiming to test a healthcare-community program that delivers healthy food weekly and provides nutrition education to pregnant women with type 1 or type 2 diabetes who have food insecurity, to improve blood sugar and pregnancy outcomes.

  Recruiting Ohio State University · Columbus, Ohio · NCT07560813

• NIRS for EDResp: Which first helps hypoxemic adults best?

  This trial tests whether non-invasive ventilation with a mask (NIPPV) or high-flow nasal oxygen (HFNO) is more helpful for adults in the emergency department with acute hypoxemic respiratory failure.

  Recruiting at 9 sites Ohio State University · Tucson, Arizona and 8 other locations · NCT07558265

• Compare two suction ureteroscope devices for kidney stones (FANS vs CVAC)

  This study tests whether two new suction-enabled ureteroscopes (FANS and CVAC) lead to better stone clearance for adults with small to medium kidney stones compared to each other.

  Recruiting Ohio State University · Columbus, Ohio · NCT07514351

• Metric-Optimized Glasses for Children with Down Syndrome

  This study tests whether glasses prescribed from computer analysis of eye images help improve vision in children with Down syndrome more than glasses prescribed by standard eye exams.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT07490444

• Blood markers of stress during periodontal treatment

  This study tests how inflammatory blood markers change during periodontal surgery compared with non-surgical dental care in adults.

  Recruiting Ohio State University · Columbus, Ohio · NCT07468929

• Soy-tomato juice for people with recurrent acute or chronic pancreatitis

  This will try giving daily soy-tomato juice to people with recurrent acute or chronic pancreatitis to see if they can tolerate it and whether it reduces inflammation and symptoms.

  Recruiting Phase 1/2 Ohio State University · Columbus, Ohio · NCT07447687

• Measuring how a gum graft heals

  This project will take non-invasive scans, blood-flow readings, and saliva samples from people getting a gum graft to see how the graft heals over time.

  Recruiting Ohio State University · Columbus, Ohio · NCT07386457

• Matched microcatheter and guidewire use for middle meningeal artery embolization in chronic subdural hematoma

  This will test whether using a matched Aristotle 14 guidewire and Plato 17 microcatheter during middle meningeal artery embolization works better than surgeons' usual device choices for adults with chronic subdural hematoma.

  Recruiting Ohio State University · Columbus, Ohio · NCT07324551

• Daily disposable toric contact lenses for long-day wear.

  This will test whether daily disposable toric contact lenses stay comfortable and provide clear vision for people with astigmatism who wear lenses for long days.

  Recruiting Ohio State University · Columbus, Ohio · NCT07303920

• Permissive versus strict blood sugar control during labor for pregnant people with type 1 diabetes

  This trial will test whether allowing slightly higher blood sugars (70–140 mg/dL) during labor is as safe for newborns as keeping tighter control (70–110 mg/dL) for pregnant people with type 1 diabetes using hybrid closed‑loop insulin systems.

  Recruiting Phase 4 Ohio State University · Columbus, Ohio · NCT07293715

• BAM Index: measuring arm and hand behavior in infants and toddlers

  This project tries a set of behavioral measurements to see if they can reliably describe arm, hand, and other developmental skills in infants and toddlers with and without perinatal stroke or hemiparetic cerebral palsy.

  Recruiting Ohio State University · Columbus, Ohio · NCT07291479

• Reducing Parental Substance Use and Boosting Family Resilience in Rural Ohio

  This study tests whether nearby substance use treatment referrals and family peer mentoring through Ohio START help rural parents reduce substance use and improve child and family wellbeing.

  Recruiting Ohio State University · Columbus, Ohio · NCT07278427

• Telehealth parent coaching to use adaptive standers for young children with severe motor delays

  This program will test whether telehealth parent coaching to use adaptive standers for children ages 1–6 with severe motor delays increases child physical activity, improves sleep and endurance, and reduces parent stress.

  Recruiting Ohio State University · Columbus, Ohio · NCT07252713

• Irrisept to reduce urinary tract infections when a urethral catheter is removed

  This study tests whether rinsing the bladder with Irrisept (0.05% chlorhexidine) instead of saline at the time of catheter removal reduces UTIs in adults having their urethral catheter removed.

  Recruiting Ohio State University · Columbus, Ohio · NCT07239219

• Crisis Response Planning added to intensive Cognitive Processing Therapy to reduce suicide risk in PTSD

  We will test whether adding Crisis Response Planning to intensive Cognitive Processing Therapy helps reduce suicidal thoughts and behaviors in military members and veterans with PTSD.

  Recruiting Ohio State University · Fort Hood, Texas · NCT07238192

• Keto-adaptation to improve PCOS symptoms and ovulation

  This 12-week trial will test whether a ketogenic diet or taking exogenous ketones helps women with PCOS restore regular ovulation and improve hormone and metabolic health.

  Recruiting Ohio State University · Columbus, Ohio · NCT07227363

• Zilucoplan for severe gMG flares that require hospitalization.

  This trial will try daily subcutaneous zilucoplan in adults with AChR-positive generalized myasthenia gravis who are hospitalized for severe flares to see if it quickly improves breathing and bulbar symptoms.

  Recruiting Phase 3 Ohio State University · Tampa, Florida and 2 other locations · NCT07215949

• TBI-RECOVER in Outpatient Substance Use Treatment

  This trial tests whether the TBI-RECOVER program can help people with a substance use disorder who have a brain injury, by improving retention in treatment and managing cognitive and behavioral challenges.

  Recruiting Ohio State University · Columbus, Ohio · NCT07215221

• Blocking orexin receptors to reduce alcohol use and stress-related drinking

  This trial tests whether taking suvorexant at bedtime helps adults with moderate to severe alcohol use disorder drink less and have smaller stress reactions.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT07214207

• SPIRIT Club exercise platform for adults with chronic brain injury

  This project will test a new SPIRIT Club online exercise section to help adults with chronic brain injury become more active and confident in exercising.

  Recruiting Ohio State University · Columbus, Ohio · NCT07169370

• Vitamin C to improve gut barrier function and reduce inflammation in adults with obesity

  This trial will see if taking vitamin C daily can strengthen the gut barrier and reduce inflammation in adults with obesity.

  Recruiting Ohio State University · Columbus, Ohio · NCT07151105

• CDH1-linked Blepharocheilodontic Syndrome Registry

  This registry will see if collecting health and genetic information from people with CDH1 variants and Blepharocheilodontic Syndrome (BCDS) clarifies their clinical features and possible cancer risks.

  Recruiting Ohio State University · Columbus, Ohio · NCT07133464

• Mindfulness-based Psilocybin Therapy for PTSD

  This study tests whether psilocybin given with mindfulness-based therapy helps PTSD symptoms in adults who also have depression.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT07104916

• AquOTic water-safety and swim-skills program for children with autism

  This 10-week occupational therapy–led program will try to improve water safety and swimming skills in children aged 5–9 on the autism spectrum by comparing delivery by student professionals versus trained community interventionists.

  Recruiting Ohio State University · Columbus, Ohio · NCT07076264

• Food and Fitness With Medicine for Post‑menopausal Women with Type 2 Diabetes and Cardio‑Kidney‑Metabolic Syndrome

  This 24‑week randomized test sees if adding tailored groceries, nutrition counseling, culinary education, and supervised exercise helps post‑menopausal women with type 2 diabetes who just started GLP‑1 receptor agonists stay on their medicine and improve heart and metabolic health.

  Recruiting Ohio State University · Columbus, Ohio and 3 other locations · NCT07027995

• Optimizing early phonological skills to improve later reading and spelling

  We will test whether two types of phonological awareness lessons for prekindergarten and kindergarten children with below-average phonological skills help improve later reading and spelling.

  Recruiting at 2 sites Ohio State University · Tallahassee, Florida and 1 other locations · NCT07017010

• Virtual training for home healthcare workers on safety

  This study is testing a new online safety training for home healthcare workers to see if it helps them spot and handle hazards in real-life situations.

  Recruiting Ohio State University · Columbus, Ohio · NCT06974708

• Using music to improve therapy for PTSD

  This study is testing if listening to special music before therapy sessions can help people with PTSD feel better.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT06925867

• Mobile app plus printed booklets to help adults manage sickle cell disease

  This project will test whether a mobile app combined with printed patient-facing sickle cell guidelines helps adults with sickle cell disease use less emergency and hospital care than printed booklets alone.

  Recruiting at 4 sites Ohio State University · Chicago, Illinois and 3 other locations · NCT06919224

• Diet and exercise to manage low blood pressure after meals in spinal cord injury patients

  This study is testing if a special diet and electrical exercises can help people with spinal cord injuries manage low blood pressure after meals.

  Recruiting Ohio State University · Columbus, Ohio · NCT06882460

• Using acellular collagen matrix to aid wound closure after bone grafting for dental implants

  This study tests whether using a special collagen material can help wounds heal better after bone grafting for dental implants.

  Recruiting Ohio State University · Columbus, Ohio · NCT06871735

• One dose of CYB003 for depression and anxiety

  This study tests whether a single dose of CYB003, a psilocin-related compound, can help symptoms in adults with major depressive disorder and anxiety compared to a placebo.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06820723

• Assessing motor and voice development in infants

  This study is trying to see if watching videos of infants can help spot early signs of physical disabilities, especially for those at risk of Cerebral Palsy, by looking at their movement and voice development.

  Recruiting Ohio State University · Columbus, Ohio · NCT06807203

• Early literacy support through educational media and shared reading

  This study will see if caregiver-led educational media activities help children ages 42–57 months improve early literacy skills compared with shared book reading or no intervention.

  Recruiting Ohio State University · Columbus, Ohio · NCT06796790

• Digital intervention to reduce alcohol use in patients receiving opioid treatment

  This study tests a digital program designed to help people in opioid treatment reduce their heavy drinking and improve their overall health.

  Recruiting Ohio State University · Columbus, Ohio · NCT06718491

• Giving a single oral antibiotic dose with Bulkamid urethral bulking.

  This will see if one dose of oral antibiotics given before Bulkamid urethral bulking lowers early urinary tract infections in people treated for stress‑predominant urinary incontinence.

  Recruiting Phase 4 Ohio State University · Columbus, Ohio · NCT06706362

• How mild inflammation affects impulsive aggression

  We will test whether a low-dose inflammatory infusion (endotoxin) increases anger, hostile thinking, and aggressive behavior in adults with intermittent explosive disorder compared with similar adults without that history.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06665074

• Atorvastatin after pregnancy to lower future heart disease risk

  This study will test whether taking atorvastatin for three months after stopping breastfeeding lowers future cardiovascular risk in people who had high blood pressure during pregnancy.

  Recruiting Phase 4 Ohio State University · Columbus, Ohio · NCT06632379

• Reducing fall risk for older adults receiving home-delivered meals

  This study tests different ways of delivering meals to see if adding dietitian or therapy services can help older adults at risk of falls stay safer and healthier at home.

  Recruiting Ohio State University · Columbus, Ohio · NCT06586970

• Using SAGE and a Coding test to check thinking skills in Huntington's disease

  We will test whether two quick thinking tests—the Self‑Administered Gerocognitive Examination (SAGE) and a Coding test—work well for adults with genetic Huntington's disease.

  Recruiting Ohio State University · Columbus, Ohio · NCT06546488

• Testing LH-001 in healthy participants

  This study is testing a new medication called LH-001 in healthy people to see if it's safe to take in single or multiple doses.

  Recruiting Phase 1 Ohio State University · Columbus, Ohio · NCT06546449

• Treatment for digestive issues after acute pancreatitis

  This study is testing if a 6-month treatment with pancrelipase can help adults with digestive problems after having acute pancreatitis feel better.

  Recruiting at 4 sites Phase 4 Ohio State University · Los Angeles, California and 5 other locations · NCT06477159

• Comparing two doses of aspirin to prevent pregnancy-related high blood pressure issues

  This study is testing if a higher dose of aspirin can better prevent high blood pressure problems during pregnancy for women at risk.

  Recruiting at 15 sites Phase 4 Ohio State University · Birmingham, Alabama and 19 other locations · NCT06468202

• Comparing Metformin and Insulin for Gestational Diabetes Treatment

  This study is testing whether metformin is as effective as insulin for treating gestational diabetes in pregnant people and looks at how safe both treatments are for mothers and their babies.

  Recruiting at 22 sites Phase 4 Ohio State University · Tuscaloosa, Alabama and 25 other locations · NCT06445946

• Improving management of preterm premature rupture of membranes with antibiotics

  This study is testing if a new combination of antibiotics can help pregnant people with preterm premature rupture of membranes stay pregnant longer and have healthier babies compared to the usual treatment.

  Recruiting at 2 sites Phase 4 Ohio State University · Columbus, Ohio and 1 other locations · NCT06396078

• Comparing two methods for collecting bone marrow in hip surgery

  This study is testing a new way to collect bone marrow during hip surgery to see if it works better than the standard method for helping patients with bone loss heal.

  Recruiting Ohio State University · Columbus, Ohio · NCT06388993

• Developing a training curriculum for cardiothoracic critical care

  This study is trying to create a training program for doctors who care for patients with heart and lung issues by getting expert opinions on what skills and knowledge are most important.

  Recruiting Ohio State University · Columbus, Ohio · NCT06370338

• Using linoleic acid-rich oil to improve muscle strength in older adults

  This study is testing if taking a daily dose of linoleic acid-rich oil can help older adults with muscle weakness feel stronger and move better.

  Recruiting Ohio State University · Columbus, Ohio · NCT06361511

• Identifying delirium in older patients with dementia in the emergency department

  This study is testing a wrist sensor to see if it can help doctors better identify delirium in older patients with dementia who come to the emergency room.

  Recruiting Ohio State University · Columbus, Ohio · NCT06326424

• Effect of a Ketogenic Diet on Polycystic Kidney Disease

  This study is testing if following a ketogenic diet for a year can help people with polycystic kidney disease keep their kidneys healthier and slow down the disease.

  Recruiting Ohio State University · Columbus, Ohio · NCT06325644

• Preventing opioid use disorder in homeless youth

  This study is testing different support methods to help homeless youth avoid opioid use and improve their mental health.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT06311838

• Using spinal cord stimulation to treat diabetic peripheral neuropathy

  This study is testing if spinal cord stimulation can help people with diabetic peripheral neuropathy feel less pain and improve their nerve health.

  Recruiting Ohio State University · Columbus, Ohio · NCT06287736

• Improving treatment for suicidal individuals with PTSD

  This study is testing if combining prolonged exposure therapy with a crisis response plan can help people with PTSD reduce their suicidal thoughts and behaviors better than standard treatment.

  Recruiting Ohio State University · Columbus, Ohio · NCT06285708

• Integrated care for mothers and infants to improve postpartum health

  This study is testing a new care program for new moms and their babies to see if it can help reduce postpartum depression, anxiety, and health issues in the year after childbirth.

  Recruiting Ohio State University · Columbus, Ohio · NCT06277661

• Improving birth outcomes through technology and education

  This study is testing a new program that uses text messages and support to help pregnant women in Ohio have healthier pregnancies and reduce issues like anemia.

  Recruiting at 3 sites Ohio State University · Columbus, Ohio and 2 other locations · NCT06261398

• Monitoring therapeutic response during pregnancy for preeclampsia

  This study is testing if blood samples from pregnant people at risk for preeclampsia can help us understand how well aspirin works in protecting both the mother and baby during pregnancy.

  Recruiting Ohio State University · Columbus, Ohio · NCT06249178

• Using a nerve block for pain control in open heart surgery

  This study is testing if a special pain relief method using a nerve block can help people feel less pain after open-heart surgery compared to a regular treatment.

  Recruiting Ohio State University · Columbus, Ohio · NCT06233318

• Rotating a stylet-loaded endotracheal tube before intubation to reduce throat soreness

  This study is testing if turning a special type of breathing tube before putting it in can help reduce throat soreness after surgery.

  Recruiting Ohio State University · Columbus, Ohio · NCT06231342

• Impact of Dietary Fats on Cognitive Function

  This study tests whether eating walnuts or a dairy-free chocolate bar can improve thinking and memory in adults who feel their brain isn't working as well as it used to.

  Recruiting Ohio State University · Columbus, Ohio · NCT06223672

• Monitoring glucose levels in women after gestational diabetes

  This study is testing if wearing a continuous glucose monitor can help women who had gestational diabetes keep track of their blood sugar levels after giving birth.

  Recruiting Ohio State University · Columbus, Ohio · NCT06184373

• Using advanced MRI to guide chemotherapy for pancreatic cancer

  This study is testing whether using advanced MRI to guide chemotherapy can help shrink pancreatic tumors so they can be surgically removed.

  Recruiting at 2 sites Ohio State University · Indianapolis, Indiana and 1 other locations · NCT06173310

• Understanding brain activity during alcohol intoxication and aggression

  This study tests how drinking alcohol affects brain activity related to social cues and aggression in people.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06118580

• Testing nitrous oxide for reducing aggression in impulsive individuals

  This study is testing if breathing in nitrous oxide can help people with Intermittent Explosive Disorder and healthy individuals by seeing if it changes how their brains work when it comes to controlling aggression.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT06118567

• Using 3D printing to enhance nasal irrigation for chronic rhinosinusitis

  This study is testing if 3D printed models of patients' noses can help people with chronic rhinosinusitis use nasal irrigation more effectively and feel better without surgery.

  Recruiting Ohio State University · Columbus, Ohio · NCT06118554

• Creating a tool to predict treatment outcomes for suicidal service members

  This study is testing a new tool to help figure out which military personnel struggling with suicidal thoughts will do better with regular treatment or a special therapy called Brief Cognitive Behavioral Therapy.

  Recruiting Ohio State University · Columbus, Ohio · NCT06094218

• New diagnostic methods for pneumonia in older adults

  This study is testing new ways to diagnose pneumonia in older adults in the emergency room to see if they can improve accuracy in identifying different types of infections.

  Recruiting Ohio State University · Columbus, Ohio · NCT06092008

• Comparing ketogenic and low-fat diets for heart failure patients

  This study is testing whether a low carbohydrate ketogenic diet or a low-fat diet can help people with heart failure feel better and exercise more effectively over six months.

  Recruiting Ohio State University · Columbus, Ohio · NCT06081543

• Effects of a ketone ester beverage on heart function and exercise tolerance

  This study is testing if a special drink made from ketones can improve heart function and exercise ability in people with heart failure, type 2 diabetes, or metabolic syndrome.

  Recruiting Ohio State University · Columbus, Ohio · NCT06078683

• Improving resilience to sleep deprivation with diet and ketones

  This study is testing if a ketogenic diet or ketone supplements can help healthy adults handle the negative effects of not getting enough sleep.

  Recruiting Ohio State University · Columbus, Ohio · NCT06075914

• Treatment for muscle tightness after stroke, spinal cord injury, or cerebral palsy

  This study is testing a new treatment using targeted radiation to see if it can help reduce muscle tightness in people who have had a stroke, spinal cord injury, or have cerebral palsy.

  Recruiting at 2 sites Ohio State University · Winter Park, Florida and 1 other locations · NCT06070233

• Preventing suicide in homeless youth who use substances

  This study is trying out a new therapy combined with regular support to see if it can help homeless young people who use drugs and have thoughts of suicide feel better and stay safe.

  Recruiting Ohio State University · Columbus, Ohio · NCT05994612

• Understanding impulsivity and alcohol response in young adults

  This study is trying to see how impulsivity affects young adults' reactions to alcohol to find new ways to prevent and treat alcohol misuse.

  Recruiting at 2 sites Early Phase 1 Ohio State University · Boston, Massachusetts and 1 other locations · NCT05929677

• Understanding how ketone metabolism varies with age and metabolic health

  This study tests how age and metabolic health affect how people process ketone supplements, aiming to help individuals use them more effectively.

  Recruiting at 2 sites Ohio State University · Novato, California and 1 other locations · NCT05924295

• Improving nasal obstruction and smell loss evaluation

  This study is testing a new nasal aid to see if it can help people with nasal obstruction and smell loss feel better and get more personalized treatment.

  Recruiting Ohio State University · Columbus, Ohio · NCT05920330

• Randomized comparison of immediate in-hospital 2-hour OGTT versus standard 4–12 week postpartum 2-hour OGTT for people with gestational diabetes

  This will test whether doing a 2-hour OGTT before hospital discharge gets more people who had gestational diabetes screened for diabetes than the usual 4–12 week outpatient test.

  Recruiting Ohio State University · Columbus, Ohio · NCT05909046

• Using Pimavanserin to Reduce Aggression in Intermittent Explosive Disorder

  This study is testing whether a single dose of pimavanserin can help reduce aggressive behavior in people with Intermittent Explosive Disorder.

  Recruiting Phase 2 Ohio State University · Columbus, Ohio · NCT05895513

• Identifying immune profiles in acute pancreatitis

  This study is trying to see if analyzing immune responses in blood samples can help predict severe cases of acute pancreatitis in people shortly after they are admitted to the hospital.

  Recruiting Ohio State University · Los Angeles, California and 4 other locations · NCT05878236

• Perceptual training to improve balance and motion sensing in older adults

  This test tries whether repeated motion-feedback training can help older adults (65–89) better detect whole-body tilts and translations and improve their balance.

  Recruiting Ohio State University · Columbus, Ohio · NCT05818787

• Adolescent brain imaging study of prenatal chemical and social exposures

  This study tests whether prenatal chemical exposures and early social stress influence brain function and behavior in teenagers.

  Recruiting Ohio State University · New York, New York · NCT05795452

• Comparing health and motion in people with low back and neck pain to healthy individuals

  This study looks at how people with low back and neck pain move and feel compared to healthy individuals to see if we can learn more about their conditions and improve treatments.

  Recruiting Ohio State University · Columbus, Ohio · NCT05776771

• Exploring emotion regulation strategies for suicidal servicemembers

  This study is testing a one-time session to help servicemembers who are having suicidal thoughts learn better ways to manage their emotions and see if it can reduce those thoughts over time.

  Recruiting Ohio State University · Columbus, Ohio · NCT05722197

• Improving blood sugar control during pregnancy for women with type 2 diabetes using technology and coaching

  This study is testing whether using a mobile app and coaching can help pregnant women with type 2 diabetes better control their blood sugar compared to regular prenatal care.

  Recruiting Ohio State University · Columbus, Ohio · NCT05662462

• Personalized emotion regulation skills training

  This study is testing if teaching people personalized ways to manage their emotions can help them feel less negative every day compared to using standard methods.

  Recruiting Ohio State University · Columbus, Ohio · NCT05651295

• Evaluating a new method for draining fluid and blood in brain hemorrhages

  This study is testing a new device for draining fluid and blood from the brain to see if it works better than the standard method for patients with brain hemorrhages.

  Recruiting Ohio State University · Columbus, Ohio · NCT05649904

• Improving diabetes care through education and food support

  This study is testing if giving fresh fruits and vegetables, diabetes education, and community support can help people with type 2 diabetes who struggle with food insecurity manage their blood sugar better.

  Recruiting Ohio State University · Columbus, Ohio · NCT05472441

• Lowering abdominal gas pressure during laparoscopic large-bowel surgery to reduce postoperative ileus

  This trial will test whether using lower abdominal inflation pressure during laparoscopic large-bowel surgery helps adults recover bowel function faster and go home sooner.

  Recruiting Ohio State University · Columbus, Ohio and 1 other locations · NCT05344417

• New rehabilitation approach for walking recovery after spinal cord injury

  This study is testing a new rehab program that combines downhill treadmill training and electrical stimulation to see if it helps people with spinal cord injuries walk better.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT05337982

• Exploring how sex differences and hormones affect alcohol use disorder risk

  This study is trying to see how differences between men and women, along with hormones, affect the risk of developing alcohol use disorder, especially in women.

  Recruiting Ohio State University · Columbus, Ohio · NCT04929288

• Comparing post-operative dressings for abdominal wall reconstruction

  This study is trying to see which type of dressing after abdominal wall surgery—vacuum therapy, self-adhering mesh, or regular dressings—works best to prevent complications like infections for patients having hernia repairs.

  Recruiting Ohio State University · Columbus, Ohio · NCT04906408

• Understanding BAP1 Hereditary Cancer Risks

  This study is trying to find out how common certain cancers are in people with BAP1 gene mutations to help improve screening and treatment for them and their families.

  Recruiting Ohio State University · Columbus, Ohio · NCT04792463

• Assessing cognitive outcomes after skull base meningioma surgery

  This study is testing how surgery for removing skull base meningiomas affects thinking and memory in patients over time.

  Recruiting Ohio State University · Columbus, Ohio · NCT04635657

• Using a new device to improve MRI measurements for pancreatic cancer treatment response

  This study is testing a new device to see if it can help doctors get more accurate MRI results when checking how well treatments are working for people with pancreatic cancer.

  Recruiting at 2 sites Ohio State University · Columbus, Ohio and 1 other locations · NCT04588025

• Assessing outcomes of cervical fusion with interfacet spacers

  This study is testing how well a new type of spacer works in helping patients recover from neck surgery and if it can prevent complications like nerve problems.

  Recruiting Ohio State University · Columbus, Ohio · NCT04041583

• Evaluating a new treatment for adolescent depression

  This study is testing a new therapy for teenagers with a history of depression to see if it can help prevent them from feeling depressed again.

  Recruiting at 3 sites Ohio State University · Columbus, Ohio and 2 other locations · NCT03859297

• High-resolution MRI imaging for patients with atrial fibrillation before ablation

  This study is testing if detailed MRI scans can help doctors better understand the heart's structure in patients with atrial fibrillation before they undergo a procedure to treat it.

  Recruiting Ohio State University · Columbus, Ohio · NCT03444337

• Using electroacupuncture to reduce nausea after spinal surgery

  This study is testing if a special type of acupuncture can help reduce nausea and vomiting after spinal surgery for patients.

  Recruiting Ohio State University · Columbus, Ohio · NCT03187535

• Creating a biorepository for studying inflammatory skin disorders

  This study is trying to collect and analyze samples from people with and without inflammatory skin disorders to better understand these conditions and help find new treatments.

  Recruiting Ohio State University · Columbus, Ohio · NCT03146676

• Identifying differences between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

  This study is trying to tell apart Alzheimer's, Lewy Body dementia, and Parkinson's Disease by looking at brain scans, tests, and samples from people with these conditions.

  Recruiting Ohio State University · Columbus, Ohio · NCT03019757

• Effects of dry needling on knee pain management

  This study is testing if dry needling can help people with knee pain feel better and improve their movement compared to standard physical therapy or fake treatments.

  Recruiting Ohio State University · Columbus, Ohio · NCT02890485

• Gene therapy for children with AADC deficiency

  This study is testing a new gene therapy for children with AADC deficiency to see if it can improve their brain function and help them move better.

  Recruiting at 3 sites Phase 1 Ohio State University · San Francisco, California and 2 other locations · NCT02852213

• Using Magnetic Resonance Elastography to assess abdominal aortic aneurysms

  This study is testing if a new imaging technique can help doctors better understand the risk of rupture in abdominal aortic aneurysms by measuring how stiff they are.

  Recruiting Ohio State University · Columbus, Ohio · NCT02387255

• Using MRI to Measure Soft Tissue Stiffness

  This study is testing a new way to use MRI scans to see how stiff soft tissues like the liver and heart are, which could help diagnose conditions like liver fibrosis and heart failure more easily.

  Recruiting Ohio State University · Columbus, Ohio · NCT01757730

NIH-funded research (newest 40 of 1162)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Understanding how trinucleotide repeat expansions cause disease

  A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11629759

• Pediatric Prehospital Airway Resuscitation for Critically Ill Children

  This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11624827

• From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias

  This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11617700

• Understanding why patients with blood cancers start and stick with oral cancer medicines

  A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11611692

• How sex and hormones affect alcohol's impact on sleep in adults

  This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11606504

• Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer

  A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11580206

• Predicting how Alzheimer’s and related diseases progress by combining genetics and environment

  This project aims to help people with Alzheimer’s-related conditions by using genetic information together with environmental and social factors to forecast how the disease might progress over time.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11579927

• Role of MMP3 in heart dysfunction during sepsis

  This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11576508

• Ways to stop iron theft by intracellular bacteria that cause tick-borne illnesses

  This project aims to understand how certain bacteria that live inside human cells steal iron from the host and to test new ways to block that process to prevent infection.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11572324

• Understanding how vaginal tissue changes after menopause affect reproductive health

  A research team is studying why the vaginal lining changes after menopause and how this affects health, with potential solutions to improve comfort and reduce infection risk for postmenopausal women.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11570238

• One Health JEV vaccine development using dinucleotide enrichment

  A research project at Ohio State University is testing a vaccine strategy to protect people by vaccinating pigs and other animals to reduce Japanese encephalitis virus transmission.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11563776

• Right heart remodeling in pulmonary hypertension

  In people with pulmonary hypertension, researchers are studying how the right side of the heart changes and why it fails, with the goal of finding new treatments.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11533159

• Understanding how Leishmaniasis spreads in high-risk areas and animals

  A study to map how Leishmaniasis spreads in Eastern Africa and how animal hosts and vectors influence transmission, with goal of protecting people and military personnel deployed to endemic regions.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11520490

• Understanding how environmental factors and hosts drive Visceral Leishmaniasis and PKDL spread in East Africa

  A team will study how the environment, animals, and people interact to drive transmission of visceral leishmaniasis and PKDL in Eastern Africa.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11520489

• Multidisciplinary study of factors driving visceral and PKDL leishmaniasis transmission in Eastern Africa

  A team from Ohio State University is studying what drives transmission of visceral leishmaniasis and PKDL in Eastern Africa, with goals to identify hosts, vectors, and environmental factors that sustain spread.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11520040

• How viral and human RNA changes drive COVID-19 damage and new treatment approaches

  This project tests whether blocking certain RNA-modifying enzymes together with CASP11 can lower virus levels and reduce severe COVID-19 damage in infected tissues.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11517421

• Immune-driven blood clots and brain harm after COVID-19

  Looking for ways to stop immune-driven blood clots that may cause long COVID symptoms in people who had SARS-CoV-2 infection.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11517350

• Better vaccines and treatments for COVID and Long COVID

  Developing ways to strengthen immune protection against COVID-19 and reduce the chance and severity of long COVID for people who were infected or vaccinated.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11517295

• Bank of airway, blood, and brain cell samples for COVID and Long-COVID research

  This project collects and shares airway, blood, and brain cell samples from people with and without COVID-19 to help researchers find treatments for Long-COVID.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11517267

• How certain immune enzymes and RNA changes affect COVID-19 damage in lungs, heart, brain, and blood

  This project looks at whether specific immune enzymes (caspase-4/11) and changes to viral RNA change how COVID-19 harms organs, with the goal of helping develop better treatments.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11517258

• Ohio State University as a Lead Academic Organization for Experimental Therapeutics Clinical Trials Network

  Cancer patients may gain access to new therapies through a network led by Ohio State University and its partners.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11498110

• Multi-Functional Dressings to Heal Chemical Vesicant Skin Injuries

  A new wound dressing combines a fast-acting antimicrobial gel with a protein that repairs cell membranes to help heal skin injuries from chemical vesicants like sulfur mustard.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11495810

• Macrophage-Targeted Nanoparticles for Hard-to-Treat Breast Cancer

  Aims to use tiny delivery particles to turn immune cells inside breast tumors into fighters against cancer, reducing tumor growth while avoiding common antibody side effects.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11494788

• Ohio State Tobacco Center: making nicotine products less addictive and less appealing

  This center looks for ways regulators can make nicotine products like e-cigarettes and oral nicotine pouches less addictive and less appealing to people, especially young adults.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11494125

• Everyday listening and social life after cochlear implants

  This project looks at how people's daily listening and social experiences after cochlear implants help them build stronger communication skills.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11478394

• Tunable metformin-releasing injectable scaffolds to aid jaw bone regeneration

  A patient-friendly approach using metformin-releasing injectable scaffolds to support healing of large craniofacial bone defects.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11471756

• Improving everyday communication after cochlear implants

  This project explores how adults with cochlear implants can use relationships with family and friends to improve hearing and everyday communication.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11471309

• HIV-related immune changes in the mouth and KSHV infection

  This project looks at how HIV-related immune problems in the mouth may affect infection with KSHV and the risk of mouth-related cancers in people living with HIV.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11469907

• Genetic clues for doxorubicin heart risk using patient-derived heart cells

  A research project tests how human heart cells grown from stem cells react to a common chemotherapy to see which genetic differences may raise the risk of heart damage.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11468369

• Directly reprogramming heart cells to become heart cells to repair damage

  A study at Ohio State University aims to help the heart repair itself after a heart attack by turning supporting heart cells into cardiomyocyte-like cells using specific genetic instructions.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11468163

• Targeting a specific CD38 form to protect livers from injury after transplant

  A new approach tests a selective drug to protect donor livers from injury during transplant, potentially increasing usable organs and improving transplant outcomes.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11465898

• Atrial fibrillation, clots, and stroke: the heart’s JNK2 as a target

  This NIH grant explores how a heart protein called JNK2 may drive atrial fibrillation, blood clots, and stroke, and whether it could serve as a biomarker and new treatment approach.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11465511

• Dietary DHA to reduce ozone-related lung inflammation

  A study in mice and humans explores whether consuming DHA, a healthy fat, can lessen lung inflammation caused by ozone exposure, with a focus on people who are overweight or obese.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11464926

• What BSP does in your jawbone and teeth health

  This grant studies how a bone matrix protein called BSP helps form and repair jawbone and tooth-supporting tissues, which could lead to better treatments for gum disease and tooth loss.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11463776

• Pain sensitivity, alcohol analgesia, and heavy drinking in people with opioid use disorder

  A short, patient-friendly look at how pain sensitivity and alcohol’s pain-relieving effects might influence heavy drinking in people with opioid use disorder.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11461099

• Why some carbapenem-resistant bacteria stop responding to the antibiotic cefiderocol

  Researchers are looking at how carbapenem-resistant bacteria develop resistance to the antibiotic cefiderocol to help people with hard-to-treat infections.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11459867

• Progression of Social Cognitive Difficulties in Mid- and Late-Life Schizophrenia

  This project studies how social thinking problems change as people with schizophrenia age, with a focus on adults in mid to late life.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11458469

• How a STAT1 gene change alters immune responses

  This project looks at how a STAT1 gain-of-function genetic change rewires immune cells and contributes to infections and autoimmunity in people with STAT1-related disease.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11458029

• APOL1 kidney disease link: how variants hurt kidney cells and how to help

  A small NIH grant is exploring why specific APOL1 gene variants can damage kidney cells and whether lowering a key enzyme, ACOX1, could protect against this injury.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11454419

• Novel AI-powered pathway to find targets in Guillain-Barré Syndrome

  A new AI-driven approach aims to identify specific immune targets in Guillain-Barré Syndrome using single-cell T-cell data to better understand what drives nerve damage.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11453744

Quick answers

How many clinical trials run by Ohio State University are recruiting right now?

129, as of November 12, 2026. 2 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 2 countries. The most sites are in United States (129 trials), Canada (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 8, Phase 4: 7, Phase 3: 3, Early Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →