High-resolution MRI imaging for patients with atrial fibrillation before ablation
High-resolution Contrast-Enhanced MRI of Atrial Fibrillation Patients Prior to FIRM Ablation
This study is testing if detailed MRI scans can help doctors better understand the heart's structure in patients with atrial fibrillation before they undergo a procedure to treat it.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 20 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT03444337 on ClinicalTrials.gov |
What this trial studies
This observational study involves patients with symptomatic paroxysmal or persistent atrial fibrillation who are undergoing a clinically indicated ablation procedure using FIRM mapping. Participants will receive high-resolution MRI scans with gadolinium-based contrast to create detailed 3D images of the atria before the procedure. The study aims to correlate fibrotic regions in the heart with the sites targeted for ablation based on FIRM mapping. Data will be collected before, during, and after the ablation procedure to enhance understanding of the disease state and improve treatment outcomes.
Who should consider this trial
Good fit: Ideal candidates are adults aged 18 and older with symptomatic paroxysmal or persistent atrial fibrillation scheduled for ablation using FIRM mapping.
Not a fit: Patients with left atrial appendage thrombus, those unable to undergo MRI, or those who cannot receive gadolinium contrast will not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to improved targeting of ablation sites, potentially enhancing the effectiveness of atrial fibrillation treatment.
How similar studies have performed: While the approach of using MRI in conjunction with FIRM mapping is innovative, similar studies have shown promise in improving ablation outcomes, indicating potential for success.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Patients with symptomatic paroxysmal or persistent atrial fibrillation undergoing clinically-indicated ablation procedure employing FIRM mapping with pre-operative MRI. 2. Subjects must be at least 18 years of age. Exclusion Criteria: 1. LAA thrombus present on pre-procedure TEE 2. Unable to undergo MRI imaging 3. Unable to receive gadolinium contrast.
Where this trial is running
Columbus, Ohio
- Ohio State University — Columbus, Ohio, United States (Recruiting)
Study contacts
- Study coordinator: Adrianne Miller, RN
- Email: Adrianne.Miller@osumc.edu
- Phone: 614-685-4394
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.