Using Magnetic Resonance Elastography to assess abdominal aortic aneurysms
Magnetic Resonance Elastography in Patients With Abdominal Aortic Aneurysms
This study is testing if a new imaging technique can help doctors better understand the risk of rupture in abdominal aortic aneurysms by measuring how stiff they are.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 165 (estimated) |
| Ages | 20 Years and up |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT02387255 on ClinicalTrials.gov |
What this trial studies
This study aims to utilize Magnetic Resonance Elastography (MRE) to measure the stiffness of abdominal aortic aneurysms (AAA), providing a more sensitive assessment of rupture risk compared to traditional diameter measurements. By validating stiffness estimates against mechanical testing and histopathology in AAA patients undergoing surgery, the study seeks to enhance the understanding of AAA risk factors. MRE is a non-invasive technique that could revolutionize the diagnosis and treatment of various diseases by making stiffness assessments widely available.
Who should consider this trial
Good fit: Ideal candidates for this study are patients diagnosed with abdominal aortic aneurysms who can tolerate MRI procedures.
Not a fit: Patients who are claustrophobic, pregnant, or have non-MRI safe metal/devices in their body may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate risk assessments for AAA rupture, potentially improving patient outcomes.
How similar studies have performed: While MRE is already used for assessing hepatic fibrosis, its application in evaluating AAA stiffness is novel and has not been extensively tested in this context.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Must be able to lie flat on their back in the scanner for up to 60 minutes * Must be able to hold breath for up to 15 seconds Exclusion Criteria: * Patients who are claustrophobic * Patients who are pregnant * Patients with any unapproved, non-MRI save metal/devices in or on their body
Where this trial is running
Columbus, Ohio
- The Ohio State University Medical Center — Columbus, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Arunark Kolipaka, PhD — The Ohio State University Medical Center Dept. of Radiology
- Study coordinator: Kristin L Thompson, B.S.
- Email: Kristin.Thompson@osumc.edu
- Phone: 614-366-5429
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.