Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Improving treatment for suicidal individuals with PTSD

Official title: Enhancing the Effectiveness of Prolonged Exposure Among Suicidal Individuals With PTSD

Run by Ohio State University · NCT06285708 · Data updated 2026-11-12

This study is testing if combining prolonged exposure therapy with a crisis response plan can help people with PTSD reduce their suicidal thoughts and behaviors better than standard treatment.

Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment100 (estimated)
SponsorOhio State University
Academic / other
Locations1 site (Columbus, Ohio)
StatusRecruiting
StartedFebruary 26, 2024
Main results expectedDecember 2026
Study endsJune 2027
Registry record updatedJune 29, 2026
Trial IDNCT06285708 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are individuals diagnosed with PTSD or subthreshold PTSD who can understand and complete the informed consent process.

Probably not a fit

Patients with substance use disorders requiring medical management or those at imminent risk of suicide may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to reduce suicidal thoughts and behaviors in individuals with posttraumatic stress disorder (PTSD) by testing the effectiveness of prolonged exposure therapy combined with a crisis response plan. The research will compare this enhanced treatment approach to standard prolonged exposure therapy with a self-guided treatment plan. By integrating trauma-focused therapies with suicide prevention strategies, the study seeks to address a critical gap in existing PTSD treatments. Participants will undergo assessments to evaluate the impact of the combined interventions on their suicidal ideation and attempts.

Why it matters

Potential benefit: If successful, this study could significantly lower the risk of suicide among individuals suffering from PTSD.

How similar studies have gone: While prolonged exposure therapy has shown promise in reducing suicidal ideation, this specific combination with a crisis response plan is a novel approach that has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Current diagnosis of PTSD or subthreshold PTSD; ability to speak and understand the English language; and ability to complete the informed consent process.

Exclusion Criteria:

* Substance use disorder requiring medical management; imminent suicide risk warranting inpatient hospitalization or suicide-focused treatment; and impaired mental status that precludes the ability to provide informed consent (e.g., intoxication, psychosis, mania).

Where it's running

  • The Ohio State University
    Columbus, Ohio, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.