HIV-related immune changes in the mouth and KSHV infection
Official title: Impact of HIV Induced Immune Dysregulation on KSHV Oral Infection
Funded at Ohio State University · NIH-11469907 · Data updated 2026-11-12
This project looks at how HIV-related immune problems in the mouth may affect infection with KSHV and the risk of mouth-related cancers in people living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | July 8, 2026 |
| Project end | July 7, 2028 |
| Funding year | 2026 |
| Award (this year) | $433,125 |
| NIH project number | 1R21DE036505-01 |
| Project ID | NIH-11469907 on NIH RePORTER |
Who could benefit from this research
✓Could help
People with HIV infection, especially those at risk for or with KSHV-related infections or oral mucosal involvement, may be eligible.
✕Less likely to help
Individuals without HIV or those not at risk for KSHV-related complications may not benefit directly.
What this research studies
People with HIV can have altered immune responses in mucosal tissues like the tonsils. This study focusing on the oral cavity investigates how HIV-related immune dysregulation influences KSHV infection and shedding in saliva, which may drive AIDS-related malignancies. The researchers will use patient-derived samples and laboratory analysis to understand the immune and viral interactions in tonsil tissue. By uncovering these mechanisms, the work could point toward strategies to reduce oral transmission and cancer risk in HIV-infected individuals.
Why it matters
Potential benefit: Findings could lead to better prevention and treatment approaches for AIDS-related cancers linked to KSHV in people living with HIV.
How similar studies have gone: Prior work has shown links between HIV, mucosal immunity, and opportunistic infections, but detailed mechanisms in the tonsil and oral cavity remain incompletely understood.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Santoso, Netty G — Ohio State University
- Study coordinator: Santoso, Netty G
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.