Impact of Dietary Fats on Cognitive Function

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research investigates how dietary fats, specifically walnuts and a dairy-free chocolate bar, affect cognitive function after meals in adults experiencing subjective cognitive complaints. Participants will consume one of the study snacks daily for a week, and the study will measure changes in cognitive performance and the gut-brain axis. The trial employs a randomized crossover design to ensure robust comparisons between the effects of the different dietary fats.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjective cognitive impairment
* BMI ≥30 kg/m2
* HbA1C \<6.5%

Exclusion Criteria:

* Diagnosis og cognitive impairment or dementia
* Montreal Cognitive Assessment (MoCA) score of \<26
* Current or previous diagnosis of Diabetes or use of diabetes medications
* Current diagnosis of or current treatment of cancer other than non-melanoma skin cancer
* Gastrointestinal diseases or disorders (including pancreatic and gastric bypass surgery) where consumption of the study foods would be contraindication or where the disease or disorder could negatively affect nutrient absorption and/or would prevent participants from tolerating the study foods
* Hyperthyroidism diagnosis
* Food Allergy or intolerances
* Any dietary restriction where consumption of the study foods, study meals/snack or meal challenge or any ingredient would be contraindicated
* Use of some oil supplements in the past 4 weeks prior to enrolling
* Pregnancy and lactation
* Inability to access veins for venipuncture
* Antibiotic use in the past month
* Psychostimulant or nootropic medication use
* Current use of supplements or medications for weight loss or following a weight loss program
* Severe or uncontrolled autoimmune diseases
* Current or previous diagnosis of severe kidney failure, liver cirrhosis and some pulmonary diseases
* Heart disease events (including stroke or heart attack) within last 3 months prior to enrollment
* Alcohol or drug abuse

Where it's running

• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Martha Belury, PhD, RDN — Ohio State University
• Study coordinator: Martha Belury, PhD, RDN
• Email: belury.1@osu.edu
• Phone: 614-292-1680

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.