Using acellular collagen matrix to aid wound closure after bone grafting for dental implants
Acellular Collagen Matrix (Mucograft) as a Tool to Obtain Wound Closure Following GBR Procedures
This study tests whether using a special collagen material can help wounds heal better after bone grafting for dental implants.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 30 (estimated) |
| Ages | 21 Years to 75 Years |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT06871735 on ClinicalTrials.gov |
What this trial studies
This study focuses on the use of an acellular collagen matrix to improve wound closure following a guided bone regeneration (GBR) procedure, which is necessary when there is insufficient bone volume for dental implants. Participants will undergo GBR, and if the barrier membrane remains exposed, the acellular collagen matrix will be applied to enhance healing. The study aims to evaluate the effectiveness of this approach in achieving stable wound closure and promoting bone volume increase. The methodology includes surgical site preparation, bone graft placement, and careful monitoring of healing outcomes.
Who should consider this trial
Good fit: Ideal candidates are patients with missing teeth who require a GBR procedure and are systemically healthy without contraindications for surgery.
Not a fit: Patients with sufficient bone volume for conventional implant placement or those needing soft tissue grafting may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to improved healing and better outcomes for patients undergoing dental implant procedures.
How similar studies have performed: While the use of acellular collagen matrices in similar contexts has shown promise, this specific application in GBR is being evaluated for its effectiveness.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Have a missing tooth or teeth which are planned to be replaced with an implant * Need for guided bone regeneration procedure to increase the bone available for implant placement * Systemically healthy with no contraindications for bone grafting and/or implant surgery * No chronic sinus problems * Non-smoker * No need for removable temporary restorations during wound healing. Exclusion Criteria: * Patients that have sufficient bone volume to perform implant placement through conventional drilling protocol without any pre-implant GBR procedure * Indications for pre-implant/pre-GBR soft tissue grafting procedure to increase existing soft tissue contours * The need to wear a removable temporary restoration during healing
Where this trial is running
Columbus, Ohio
- The Ohio State University Graduate Periodontics Clinic — Columbus, Ohio, United States (Recruiting)
Study contacts
- Study coordinator: Binnaz Leblebicioglu, DDS, MS, PhD
- Email: leblebicioglu.1@osu.edu
- Phone: 614-292-0371
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.