Improving resilience to sleep deprivation with diet and ketones

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates whether a ketogenic diet or ketone supplementation can mitigate the negative effects of sleep deprivation in healthy adults aged 18-40. Participants will undergo a 5-day sleep restriction followed by a 6-week dietary intervention involving either a ketogenic diet, a mixed diet with placebo, or a mixed diet with ketone esters. The study employs a double-blind, randomized design to ensure unbiased results, with assessments of physical and cognitive performance before and after the intervention. The goal is to determine if dietary changes can enhance resilience against the cognitive and physical impairments caused by lack of sleep.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Healthy, 18-40 years old.
* BMI: 20-35 kg/m2
* Sleep at least 7h per night.
* Willing to participate in \~9-weeks of testing and provided food.
* Willing to adhere to all study procedures.

Exclusion Criteria:

* \<18 or \>40 years of age
* \>35 body mass index (BMI).
* Diagnosed sleeping disorders (i.e., sleep apnea, insomnia).
* Gastrointestinal disorders or food allergies that would interfere with consuming the study supplements.
* Drink alcohol in excess of 3 drinks/day or 14 drinks/week
* Have any conditions or contraindications to blood draws.
* Have been diagnosed with diabetes, liver, kidney, or other metabolic or endocrine dysfunction, or use diabetic medications other than metformin
* Currently consume a low carbohydrate or ketogenic diet or have done so in the last 3 months
* Have experienced weight loss of \>10% of your body weight within the last 6 months
* Are pregnant, lactating, or planning on becoming pregnant during the study
* Have any major psychiatric disorders (e.g., schizophrenia, bipolar disorder)

Where it's running

• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jeff S Volek, PhD — Ohio State University
• Study coordinator: Jeff S Volek, PhD, RD
• Email: volek.1@osu.edu
• Phone: 6146881701

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.