Using MRI to Measure Soft Tissue Stiffness
Official title: Magnetic Resonance Elastography as a Method to Estimate Stiffness of Soft Tissues
Run by Ohio State University · NCT01757730 · Data updated 2026-11-12
This study is testing a new way to use MRI scans to see how stiff soft tissues like the liver and heart are, which could help diagnose conditions like liver fibrosis and heart failure more easily.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Status | Recruiting |
| Started | March 2012 |
| Main results expected | March 1, 2030 |
| Study ends | March 1, 2030 |
| Registry record updated | October 21, 2026 |
| Trial ID | NCT01757730 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults aged 18 and older who are safe for MRI procedures.
✕Probably not a fit
Patients with unapproved metal implants, those who are pregnant, or individuals with claustrophobia may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study utilizes Magnetic Resonance Elastography (MRE), a non-invasive imaging technique, to assess the stiffness of soft tissues such as the liver, heart, and kidneys. Participants will undergo an MRI scan while a paddle is placed on the area of interest to transmit sound vibrations, which are then captured by the MRI to create stiffness maps. The goal is to provide a more accessible and less invasive method for diagnosing conditions like liver fibrosis and heart failure compared to traditional techniques. MRE has the potential to improve the understanding and management of various diseases affecting soft tissue stiffness.
Why it matters
Potential benefit: If successful, this technique could lead to earlier and more accurate diagnoses of conditions like liver fibrosis and heart failure, improving patient outcomes.
How similar studies have gone: Other studies have shown that Magnetic Resonance Elastography is effective in assessing liver stiffness, indicating a promising approach for similar applications.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Any participant 18 years or older and are MR safe. Exclusion Criteria: That study participants will be excluded if they have any unapproved metal in their bodies, or if the volunteers are pregnant or possible of becoming pregnant. Also if the participants are claustrophobic.
Where it's running
-
The Ohio State University Wexner Medical Center
Columbus, Ohio, United States Recruiting
Study contacts
- Principal investigator: Arunark Kolipaka, PhD — Ohio State University
- Study coordinator: Arunark Kolipaka
- Email: arunark.kolipaka@osumc.edu
- Phone: 614-366-0268
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.