Right heart remodeling in pulmonary hypertension
Official title: Right ventricle remodeling in pulmonary hypertension
Funded at Ohio State University · NIH-11533159 · Data updated 2026-11-12
In people with pulmonary hypertension, researchers are studying how the right side of the heart changes and why it fails, with the goal of finding new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $48,386 |
| NIH project number | 3R01HL167963-03S1 |
| Project ID | NIH-11533159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with pulmonary hypertension whose right heart function is impaired and who might benefit from future therapies derived from this research.
✕Less likely to help
Patients without right heart dysfunction related to pulmonary hypertension or those not eligible for future trials may not benefit from the direct outcomes.
What this research studies
This project looks at how the right ventricle behaves differently from the left ventricle in pulmonary hypertension and why drugs that help the left ventricle may not help the right. It uses animal models to compare the biology of the two ventricles, focusing on immune and fibrotic processes. The team plans to use gene expression analysis and flow cytometry to understand cell types and signaling in the stressed right ventricle. The ultimate aim is to uncover new, targeted ways to treat right heart dysfunction instead of relying on transplantation.
Why it matters
Potential benefit: If successful, the work could lead to new therapies that protect or repair the right ventricle in pulmonary hypertension, potentially reducing the need for transplantation.
How similar studies have gone: Previous work has shown distinct differences between the right and left ventricles in disease, supporting the potential for targeted therapies to emerge from this line of study.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Gorr, Matthew William — Ohio State University
- Study coordinator: Gorr, Matthew William
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.