Immune-driven blood clots and brain harm after COVID-19
Official title: Project-003
Funded at Ohio State University · NIH-11517350 · Data updated 2026-11-12
Looking for ways to stop immune-driven blood clots that may cause long COVID symptoms in people who had SARS-CoV-2 infection.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | April 10, 2024 |
| Project end | March 31, 2029 |
| Funding year | 2026 |
| Award (this year) | $651,667 |
| NIH project number | 5P01AI175399-03 |
| Project ID | NIH-11517350 on NIH RePORTER |
Who could benefit from this research
✓Could help
People who had COVID-19 and now have ongoing symptoms, especially neurological complaints or evidence of abnormal blood clotting, would be the most likely candidates.
✕Less likely to help
Those without prior SARS-CoV-2 infection or whose symptoms are not related to clotting or immune-driven inflammation are unlikely to benefit directly.
What this research studies
This project looks at how the innate immune system helps form blood clots and triggers damaging inflammation in the lungs, brain, and bloodstream after SARS-CoV-2 infection. Researchers will analyze blood and related samples and use laboratory models to trace interactions between immune cells and clotting factors. The team will also test candidate drugs, in collaboration with other projects in the program, to block these harmful immune-clotting processes. Findings aim to point to new treatment targets to prevent or reduce long COVID symptoms tied to clots and brain inflammation.
Why it matters
Potential benefit: Could lead to new treatments that prevent or reduce blood clots and brain inflammation linked to long COVID.
How similar studies have gone: Prior work showed some benefits from anticoagulants and immune-targeting drugs for acute COVID clotting, but treating or preventing long COVID remains largely unproven and this approach is still novel.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Amer, Amal O — Ohio State University
- Study coordinator: Amer, Amal O
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.