Identifying differences between Alzheimer's, Lewy Body Dementia, and Parkinson's Disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to differentiate between Alzheimer's disease, Lewy Body dementia, and Parkinson's Disease by analyzing various clinical, neuropsychological, and neuroimaging data. Participants will undergo a series of evaluations including structural and functional MRIs, daTscans, and PET scans, along with neuropsychological testing and polysomnography. The study will also involve collecting cerebrospinal fluid and genetic samples to enhance diagnostic accuracy. A responsible study partner will assist in gathering behavioral and functional measures to support the findings.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Subjects must meet the standard clinical criteria of the syndromes of interest
* All subjects must have enough cognitive abilities to complete study procedures, which will be operationally defined as having a Mini Mental State Examination (MMSE) score greater or equal to 10.
* Subjects must be on stable cognitive and psychoactive medication regimen for the preceding four weeks of enrollment.
* Subjects must have a responsible study partner that either lives with them or is in regular contact with them at least 4 out of 7 days per week.
* Subjects must have visual and auditory acuity adequate for testing.

Exclusion Criteria:

* Any other condition (other than the primary diagnosis), which in the opinion of the investigators might contribute to the syndrome of dementia or complicate its assessment.
* active medical disorder that could preclude participation in this protocol
* Women who are pregnant or are breast feeding
* severe renal impairment as defined by glomerular filtration rate (GFR) less than 30 (may have increased radiation exposure with the DaTscan).
* Subjects in whom English is not the 1st language
* Subjects with educational level less than 12 years
* Subjects who have ever participated in an experimental study with an amyloid targeting agent unless it can be documented that the subject received only placebo during the course of the trial.

Where it's running

• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Douglas W Scharre, MD — Ohio State University
• Study coordinator: Jennifer Icenhour
• Email: jennifer.icenhour@osumc.edu
• Phone: 614-293-6882

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.