Role of MMP3 in heart dysfunction during sepsis
Official title: Role of MMP3 in cardiac microvascular barrier dysfunction and heart failure during sepsis
Funded at Ohio State University · NIH-11576508 · Data updated 2026-11-12
This research tests whether blocking MMP3 can protect the heart and improve survival during sepsis in adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 15, 2025 |
| Project end | June 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $687,601 |
| NIH project number | 7R01HL181607-02 |
| Project ID | NIH-11576508 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with sepsis or at risk for sepsis-induced heart problems, or those who could donate samples for related studies.
✕Less likely to help
Patients without sepsis or with non-cardiac complications may not directly benefit from this research.
What this research studies
In sepsis, infection-triggered organ failure often damages the heart and blood vessels. The project looks at how MMP3 affects microvascular leakage and heart function, using both human data and animal models. It aims to see if reducing MMP3 can prevent cardiac edema, stabilize blood pressure, and improve outcomes in septic conditions. The team will analyze gene and protein data, study heart tissue in mice lacking MMP3, and explore potential diagnostic value of MMP3 in patients with sepsis.
Why it matters
Potential benefit: If successful, this work could lead to new therapies that protect the heart in septic patients and improve survival.
How similar studies have gone: Preclinical data suggest that reducing MMP3 improves heart function and survival in septic models, supporting further exploration in humans.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Wu, Rongxue "Rosie" — Ohio State University
- Study coordinator: Wu, Rongxue "Rosie"
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.