Preventing suicide in homeless youth who use substances

Suicide Prevention for Substance Using Youth Experiencing Homelessness

Not applicable Interventional Ohio State University · NCT05994612

This study is trying out a new therapy combined with regular support to see if it can help homeless young people who use drugs and have thoughts of suicide feel better and stay safe.

Quick facts

PhaseNot applicable
Study typeInterventional
Enrollment300 (estimated)
Ages15 Years to 24 Years
SexAll
SponsorOhio State University Academic / other
Locations1 site (Columbus, Ohio)
Trial IDNCT05994612 on ClinicalTrials.gov

What this trial studies

This study aims to address the high rates of suicide among homeless youth who use substances by testing an intervention that combines Cognitive Therapy for Suicide Prevention (CTSP) with standard services. The research will involve 300 participants aged 15-24 who have experienced suicidal ideation or attempts, randomly assigned to receive either CTSP plus usual services or usual services alone. The effectiveness of the intervention will be evaluated over 12 months, focusing on suicidal thoughts, substance use, and depressive symptoms. The study seeks to fill a critical gap in effective prevention strategies for this vulnerable population.

Who should consider this trial

Good fit: Ideal candidates are homeless youth aged 15-24 who have experienced recent suicidal thoughts or attempts and have a history of substance use.

Not a fit: Patients who require psychiatric hospitalization will not benefit from this study.

Why it matters

Potential benefit: If successful, this intervention could significantly reduce suicidal ideation and attempts among homeless youth who use substances.

How similar studies have performed: Previous studies have shown some success with cognitive therapy interventions for youth, but this specific approach for homeless youth using substances is relatively novel.

Eligibility criteria

Show full inclusion / exclusion criteria
Inclusion Criteria:

* 15-24 years
* SSI-W score \> 4 or at least one suicide attempt in prior 12 months
* Meets criteria for homelessness
* At least four uses of alcohol/drugs in prior 30 days

Exclusion Criteria:

* Youth requires psychiatric hospitalization

Where this trial is running

Columbus, Ohio

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions Suicide Prevention
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.