Blood markers of stress during periodontal treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study measures inflammatory markers in the blood of adults undergoing either periodontal surgery or non-surgical periodontal treatment. Blood samples are collected before, during, and after the procedures to see how systemic inflammation relates to the dental interventions. The goal is to compare acute and subacute changes in inflammatory proteins between surgical and non-surgical care in a generalized periodontitis population. The research is conducted at Ohio State University’s Graduate Periodontics Clinic with IV-sedation procedures and includes adults 21–75 who are systemically healthy and non-smokers.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adults 21-75 years of age
* Systemically healthy
* Non-smoker
* scheduled to receive nonsurgical or surgical periodontal treatment under IV sedation

Exclusion Criteria:

* Patients who have localized form of the disease (less than 30% of available tooth/implant sites are affected with the disease)
* Non-english speaking individuals since informed consent form will be in English only.
* Patients with uncontrolled systemic diseases (such as metabolic diseases, obesity, diabetes, high blood pressure) since these types of chronic inflammatory challenges would cause increase levels of circulatory serum pro-inflammatory markers.
* Pregnant patients (pregnancy will be reported by the patient) since pregnancy itself would affect circulatory serum pro-inflammatory markers.
* Patients who are not willing to have blood drawing for the study purpose.
* Patients who are not willing to sign research related consent form.

Where it's running

• The Ohio State University Graduate Periodontics Clinic
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Binnaz Leblebibioglu, DDS, MS, PhD — Ohio State University

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.