Comparing post-operative dressings for abdominal wall reconstruction

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This randomized controlled trial investigates the impact of different post-operative interventions on surgical site occurrences (SSOs) in patients undergoing abdominal wall reconstruction. The study compares the effectiveness of Prevena, a vacuum-assisted therapy, Prineo, a self-adhering mesh, and traditional incisional dressings in reducing complications such as infection and seroma. By focusing on patients with complex surgical needs, the trial aims to identify which dressing method best minimizes SSOs, thereby improving patient outcomes and reducing healthcare costs. The study includes patients over 18 years old who are good surgical candidates for elective ventral hernia repair.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age \> 18
* Patients presenting for elective ventral hernia repair
* Patients deemed to be good surgical candidates, with no active life-threatening cardiac disease, pulmonary disease, renal disease, hematologic disease -Patients who will have a closed incision following the surgery

Exclusion Criteria:

* Known allergy to any material used in any wound treatment (Prevena- Acrylic adhesive or silver, Prineo- Dermabond glue, Standard- Bacitracin, Xeroform, surgical tape) -Active smokers (within the past 4 weeks) presenting for elective hernia repair
* Patients with active life-threatening cardiac disease, pulmonary disease, renal disease, hematologic disease presenting for elective ventral hernia repair
* Patients presenting for emergent ventral hernia repair (in the setting of bowel strangulation, necrosis, penetrating trauma) as it will be difficult to consent those patients for the study preoperatively
* Patients with severe systemic sepsis
* Patients with frank purulence in the wound -Patients with an open wound following surgery -Patients undergoing a panniculectomy

Where it's running

• Department of Plastic Surgery
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jeffrey E Janis, MD — Ohio State University
• Study coordinator: Jeffrey Janis, MD
• Email: Jeffrey.Janis@osumc.edu
• Phone: 6143661242

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.