Improving nasal obstruction and smell loss evaluation
Novel Mechanisms and Therapeutic Approaches for Nasal Obstruction and Olfactory Losses
This study is testing a new nasal aid to see if it can help people with nasal obstruction and smell loss feel better and get more personalized treatment.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 330 (estimated) |
| Ages | 18 Years to 70 Years |
| Sex | All |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Trial ID | NCT05920330 on ClinicalTrials.gov |
What this trial studies
This study focuses on developing new clinical tools to better assess and alleviate nasal obstruction and smell loss, which affect approximately 30 million adults in the US. It aims to investigate the underlying mechanisms of these symptoms, which are often poorly understood and inadequately treated. The researchers will explore the efficacy of a novel nasal aid designed to enhance airflow and sensory feedback, potentially leading to more personalized treatment strategies for patients. By addressing the disconnect between subjective symptoms and objective measurements, the study seeks to improve patient outcomes significantly.
Who should consider this trial
Good fit: Ideal candidates for this study are adults experiencing complaints of smell loss and nasal obstruction.
Not a fit: Patients with congenital olfactory losses, nasal polyps, or significant atrophy may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatments for patients suffering from nasal obstruction and smell loss.
How similar studies have performed: While there is limited research specifically targeting the mechanisms of nasal obstruction and smell loss, the approach of developing clinical tools for better evaluation is innovative and has not been extensively tested.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Smell Loss complaints 2. Nasal Obstruction Exclusion Criteria: 1. Congenital olfactory losses 2. Nasal polyps, blocking the olfactory cleft 3. Significant atrophy 4. Cystic fibrosis 5. Wegeners or any other connective tissue disorder 6. Head trauma
Where this trial is running
Columbus, Ohio
- Eye and Ear Institute, 915 Olentangy River Road, ENT, Suite 4000 — Columbus, Ohio, United States (Recruiting)
Study contacts
- Principal investigator: Kai Zhao, Ph.D — Associate Professor
- Study coordinator: Veronica Formanek, BS
- Email: Veronica.Formanek@osumc.edu
- Phone: 630-501-8168
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.