Improving nasal obstruction and smell loss evaluation
Official title: Novel Mechanisms and Therapeutic Approaches for Nasal Obstruction and Olfactory Losses
Run by Ohio State University · NCT05920330 · Data updated 2026-11-12
This study is testing a new nasal aid to see if it can help people with nasal obstruction and smell loss feel better and get more personalized treatment.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 70 Years |
| Sex | All |
| Enrollment | 330 (estimated) |
| Sponsor | Ohio State University Academic / other |
| Locations | 1 site (Columbus, Ohio) |
| Status | Recruiting |
| Started | January 25, 2023 |
| Main results expected | July 31, 2027 |
| Study ends | December 31, 2028 |
| Registry record updated | May 26, 2026 |
| Trial ID | NCT05920330 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults experiencing complaints of smell loss and nasal obstruction.
✕Probably not a fit
Patients with congenital olfactory losses, nasal polyps, or significant atrophy may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study focuses on developing new clinical tools to better assess and alleviate nasal obstruction and smell loss, which affect approximately 30 million adults in the US. It aims to investigate the underlying mechanisms of these symptoms, which are often poorly understood and inadequately treated. The researchers will explore the efficacy of a novel nasal aid designed to enhance airflow and sensory feedback, potentially leading to more personalized treatment strategies for patients. By addressing the disconnect between subjective symptoms and objective measurements, the study seeks to improve patient outcomes significantly.
Why it matters
Potential benefit: If successful, this study could lead to more effective and personalized treatments for patients suffering from nasal obstruction and smell loss.
How similar studies have gone: While there is limited research specifically targeting the mechanisms of nasal obstruction and smell loss, the approach of developing clinical tools for better evaluation is innovative and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Smell Loss complaints 2. Nasal Obstruction Exclusion Criteria: 1. Congenital olfactory losses 2. Nasal polyps, blocking the olfactory cleft 3. Significant atrophy 4. Cystic fibrosis 5. Wegeners or any other connective tissue disorder 6. Head trauma
Where it's running
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Eye and Ear Institute, 915 Olentangy River Road, ENT, Suite 4000
Columbus, Ohio, United States Recruiting
Study contacts
- Principal investigator: Kai Zhao, Ph.D — Associate Professor
- Study coordinator: Veronica Formanek, BS
- Email: Veronica.Formanek@osumc.edu
- Phone: 630-501-8168
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.