Clinical trial Recruiting at 1 site Interventional Ages 18 to 70

Improving nasal obstruction and smell loss evaluation

Official title: Novel Mechanisms and Therapeutic Approaches for Nasal Obstruction and Olfactory Losses

Run by Ohio State University · NCT05920330 · Data updated 2026-11-12

This study is testing a new nasal aid to see if it can help people with nasal obstruction and smell loss feel better and get more personalized treatment.

Quick facts

Study typeInterventional
Ages18 Years to 70 Years
SexAll
Enrollment330 (estimated)
SponsorOhio State University
Academic / other
Locations1 site (Columbus, Ohio)
StatusRecruiting
StartedJanuary 25, 2023
Main results expectedJuly 31, 2027
Study endsDecember 31, 2028
Registry record updatedMay 26, 2026
Trial IDNCT05920330 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates for this study are adults experiencing complaints of smell loss and nasal obstruction.

Probably not a fit

Patients with congenital olfactory losses, nasal polyps, or significant atrophy may not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on developing new clinical tools to better assess and alleviate nasal obstruction and smell loss, which affect approximately 30 million adults in the US. It aims to investigate the underlying mechanisms of these symptoms, which are often poorly understood and inadequately treated. The researchers will explore the efficacy of a novel nasal aid designed to enhance airflow and sensory feedback, potentially leading to more personalized treatment strategies for patients. By addressing the disconnect between subjective symptoms and objective measurements, the study seeks to improve patient outcomes significantly.

Why it matters

Potential benefit: If successful, this study could lead to more effective and personalized treatments for patients suffering from nasal obstruction and smell loss.

How similar studies have gone: While there is limited research specifically targeting the mechanisms of nasal obstruction and smell loss, the approach of developing clinical tools for better evaluation is innovative and has not been extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

1. Smell Loss complaints
2. Nasal Obstruction

Exclusion Criteria:

1. Congenital olfactory losses
2. Nasal polyps, blocking the olfactory cleft
3. Significant atrophy
4. Cystic fibrosis
5. Wegeners or any other connective tissue disorder
6. Head trauma

Where it's running

  • Eye and Ear Institute, 915 Olentangy River Road, ENT, Suite 4000
    Columbus, Ohio, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.