Treatment for muscle tightness after stroke, spinal cord injury, or cerebral palsy

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study tests a treatment called stereotactic radiosurgery dorsal rhizotomy, which uses precise radiation beams to target specific nerves in the back to alleviate muscle tightness or spasticity. Participants are randomly assigned to receive either the actual treatment or a sham treatment that does not have therapeutic effects. Researchers will monitor the participants' muscle stiffness and any side effects following the treatment. The goal is to determine the effectiveness of this innovative approach in reducing spasticity in patients who have not responded to traditional medical management.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Chronic spasticity refractory to medical management or in a patient who cannot receive appropriate medical management mediated by one or more spinal nerve roots
* Age \> 16 (if under 18, patients parents must sign consent).

Exclusion Criteria:

* Inability to lie supine for simulation \& treatment
* Inability to visualize the target nerve on either CT or MRI imaging
* Patients with confirmed pregnancy (all women of child-bearing age with intact uterus \& ovaries will be required to undergo a pregnancy test prior to simulation)

Where it's running

• Renaissance Institute of Precision Oncology & Radiosurgery
  Winter Park, Florida, United States Recruiting
• Ohio State University Wexner Medical Center
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Joshua Palmer, MD — Ohio State University
• Study coordinator: Uchechi Okafor, BS
• Email: SPASMstudy@osumc.edu
• Phone: (614) 2934876

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.