Exploring how sex differences and hormones affect alcohol use disorder risk

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates the factors contributing to the increasing rates of Alcohol Use Disorder (AUD) among women, particularly focusing on sex differences in risk factors such as executive function, negative emotionality, and incentive salience. It aims to understand how poor inhibitory control, which is more pronounced in women, and hormonal influences, particularly estradiol, affect these risk factors. Participants will undergo assessments related to their alcohol consumption and brain activity using fMRI to identify the neural mechanisms involved. The study seeks to provide insights that could lead to tailored interventions for AUD based on sex-specific risk factors.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* consume 4/5 drinks per week
* fluent in English
* high school education
* right-handed
* regular menstrual cycles (women)

Exclusion Criteria:

* serious medical problems
* body weight \<110 or \>210 lbs
* current medical or psychiatric conditions requiring medication for which alcohol is contraindicated
* substance use disorder other than alcohol
* current or recent history of inpatient/intensive treatment for addictive behaviors
* pregnant, nursing, on hormonal contraception
* contraindications for fMRI
* smoking \> 5 cigarettes per day

Where it's running

• The Ohio State University
  Columbus, Ohio, United States Recruiting

Study contacts

• Principal investigator: Jessica Weafer, PhD — Ohio State University
• Study coordinator: Jessica Weafer, PhD
• Email: Jessica.Weafer@osumc.edu
• Phone: 614-366-0163

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.