Progression of Social Cognitive Difficulties in Mid- and Late-Life Schizophrenia
Official title: Progression of Social Cognitive Deficits in Mid- and Late-Life Schizophrenia Spectrum Disorders
Funded at Ohio State University · NIH-11458469 · Data updated 2026-11-12
This project studies how social thinking problems change as people with schizophrenia age, with a focus on adults in mid to late life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | December 15, 2023 |
| Project end | October 31, 2028 |
| Funding year | 2027 |
| Award (this year) | $891,315 |
| NIH project number | 5R01MH135117-04 |
| Project ID | NIH-11458469 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults aged 35-75 with schizophrenia-spectrum disorders who can complete cognitive and EEG assessments.
✕Less likely to help
Individuals outside the age range or those unable to participate in the cognitive or EEG components may not directly benefit.
What this research studies
Researchers at Ohio State University will enroll about 192 adults with schizophrenia-spectrum disorders, plus comparison groups of younger patients and healthy participants, to map how social cognition changes from age 35 to 75. Participants will complete tests of social thinking, everyday functioning, and related psychiatric features, with a subset also having EEG recordings to explore brain activity linked to social processing. The study aims to identify neural markers that accompany social cognitive changes, which could guide future treatments tailored for mid- to late-life SSD. This work builds on a larger effort to understand how aging affects social abilities and which brain signals relate to these changes.
Why it matters
Potential benefit: If successful, the findings could inform targeted interventions to improve social functioning and quality of life for people with schizophrenia as they age.
How similar studies have gone: Previous work has linked social cognition deficits to functioning in schizophrenia; the combination of age-stratified sampling and neural measures represents a more comprehensive approach.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Tso, Ivy Fei — Ohio State University
- Study coordinator: Tso, Ivy Fei
Related research
Other NIH-funded projects on the same topics.
-
Understanding social disconnection in schizophrenia using digital signals and brain data
This grant explores how smartphones, social networks, and brain imaging can reveal why Veterans with schizophrenia have trouble forming and maintaining relationships, with the goal of guiding better treatments.
-
Understanding how autism and schizophrenia risk genes affect brain development
Scientists are testing how mutations in certain autism and schizophrenia risk genes change brain cells and networks, using patient-derived cells and organoids.
-
Digital support to spread team-based schizophrenia care in primary care in India
A project to help frontline health workers in India use digital tools to provide coordinated schizophrenia care in primary care, with plans to inform care in the United States as well.
-
Digital support for shared-care of schizophrenia in primary care in India
A patient-friendly plan to bring evidence-based schizophrenia care to primary care in India using digital tools and trained frontline workers.
-
Digital support to scale Schizophrenia care in primary care in India
A nationwide effort to help primary care teams in India deliver better, more accessible schizophrenia care using digital tools and trained frontline workers.
-
How social isolation affects aging health in schizophrenia
This project explores how being socially isolated may speed up health problems as people with schizophrenia age.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.