Multi-Functional Dressings to Heal Chemical Vesicant Skin Injuries
Official title: Developing Multi-Functional Dressings for Treating Chemical Vesicant-induced Skin Injury
Funded at Ohio State University · NIH-11495810 · Data updated 2026-11-12
A new wound dressing combines a fast-acting antimicrobial gel with a protein that repairs cell membranes to help heal skin injuries from chemical vesicants like sulfur mustard.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | June 22, 2026 |
| Project end | May 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $387,449 |
| NIH project number | 1R56AR084847-01A1 |
| Project ID | NIH-11495810 on NIH RePORTER |
Who could benefit from this research
✓Could help
Individuals with chemical vesicant-induced skin injuries or at high risk of exposure who could benefit from improved wound healing strategies.
✕Less likely to help
People with injuries not due to vesicants or those with conditions that contraindicate MG53-based therapies may not benefit.
What this research studies
This project develops advanced dressings that stay on the skin and fight infection while repairing damaged cell membranes to speed healing after exposure to chemical vesicants. It uses recombinant human MG53 protein to promote regeneration and reduce inflammation, paired with a rapid-gelling antimicrobial hydrogel. The goal is to create a practical, effective dressing that can be applied after exposure to improve recovery and tissue repair. The work blends material science with biology to translate membrane repair and anti-inflammatory effects into a wearable treatment for affected skin.
Why it matters
Potential benefit: If successful, patients could experience faster healing and reduced scarring after vesicant exposure.
How similar studies have gone: Previous studies show MG53 aids membrane repair and promotes healing in wound models, supporting potential effectiveness in vesicant injuries.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Li, Haichang — Ohio State University
- Study coordinator: Li, Haichang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.