One Health JEV vaccine development using dinucleotide enrichment
Official title: Development of a One Health JEV vaccine via systemic dinucleotide enrichment
Funded at Ohio State University · NIH-11563776 · Data updated 2026-11-12
A research project at Ohio State University is testing a vaccine strategy to protect people by vaccinating pigs and other animals to reduce Japanese encephalitis virus transmission.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | September 1, 2026 |
| Project end | August 31, 2027 |
| Funding year | 2026 |
| Award (this year) | $776,649 |
| NIH project number | 1R56AI198160-01 |
| Project ID | NIH-11563776 on NIH RePORTER |
Who could benefit from this research
✓Could help
Not applicable to patient enrollment in this grant; focus is on vaccine development in animals to prevent human disease.
✕Less likely to help
There is no direct patient participation in this grant as described; benefits would arise from reduced transmission to humans.
What this research studies
This project aims to develop a live attenuated JEV vaccine delivered through a One Health approach, focusing on animal hosts to cut transmission to people. Researchers will use systemic dinucleotide enrichment to enhance the vaccine’s effectiveness and safety. The study involves animal models and may include measurements of antibody responses and potential antibody-dependent enhancement to understand protection and risks. If successful, it could pave the way for protecting communities in Asia and other regions at risk from JEV by lowering human exposure.
Why it matters
Potential benefit: If successful, the approach could reduce human infections and deaths by interrupting transmission at the animal source.
How similar studies have gone: Previous vaccines and One Health strategies have reduced transmission in comparable diseases, suggesting potential for impact though this approach is novel for JEV.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Karniychuk, Uladzimir — Ohio State University
- Study coordinator: Karniychuk, Uladzimir
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.