What BSP does in your jawbone and teeth health
Official title: Functions of extracellular matrix proteins in dental and skeletal mineralization
Funded at Ohio State University · NIH-11463776 · Data updated 2026-11-12
This grant studies how a bone matrix protein called BSP helps form and repair jawbone and tooth-supporting tissues, which could lead to better treatments for gum disease and tooth loss.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | August 1, 2019 |
| Project end | July 31, 2031 |
| Funding year | 2026 |
| Award (this year) | $443,441 |
| NIH project number | 2R01DE027639-06 |
| Project ID | NIH-11463776 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are individuals with periodontal disease or tooth-supporting tissue defects who might benefit from future regenerative therapies derived from BSP research.
✕Less likely to help
People without periodontal disease or tooth-supporting tissue issues may not directly benefit from this basic research.
What this research studies
Researchers at Ohio State University will explore how bone sialoprotein (BSP) influences cementum formation, periodontal ligament integrity, and alveolar bone mineralization. They will look at BSP’s functional domains, how it affects the surrounding tissues, and how the periodontal transcriptome responds when BSP is altered. The work uses mouse models to connect BSP’s biology with actual tooth-supporting structures, aiming to uncover targets for more reliable regeneration. Findings could inform future therapies that promote healing of periodontal tissues after disease or injury.
Why it matters
Potential benefit: If successful, the work could lead to regenerative approaches for rebuilding bone and periodontal attachments around teeth.
How similar studies have gone: Previous studies show BSP is crucial for cementum and bone mineralization, supporting potential translational gains from this line of work.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Foster, Brian Lee — Ohio State University
- Study coordinator: Foster, Brian Lee
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.