Tunable metformin-releasing injectable scaffolds to aid jaw bone regeneration
Official title: Novel tunable metformin-releasing injectable scaffolds to enhance dental pulp stem cell-based craniofacial bone regeneration
Funded at Ohio State University · NIH-11471756 · Data updated 2026-11-12
A patient-friendly approach using metformin-releasing injectable scaffolds to support healing of large craniofacial bone defects.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Ohio State University NIH-funded |
| Lab location | 1 site (Columbus, UNITED STATES) |
| Project start | May 1, 2026 |
| Project end | April 30, 2029 |
| Funding year | 2026 |
| Award (this year) | $393,750 |
| NIH project number | 7R01DE032692-03 |
| Project ID | NIH-11471756 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults with craniofacial bone defects or undergoing reconstructive procedures where scaffold-assisted regeneration is feasible.
✕Less likely to help
Patients without craniofacial bone defects or not undergoing scaffolding-based regeneration may not benefit.
What this research studies
This project aims to create injectable scaffolds that slowly release metformin at a bone defect site to boost bone regeneration in the face and jaw. The approach focuses on recruiting and guiding the patient’s own bone marrow and dental pulp stem cells, along with blood vessel formation, to repair damaged bone. The research will test scaffold formulations and how well they deliver metformin to target cells in the bone tissue. Clinically, success could mean faster, stronger bone healing with fewer procedures. The team plans to leverage cells that naturally participate in repair to improve outcomes for craniofacial bone loss.
Why it matters
Potential benefit: If successful, patients with large facial bone defects could experience faster healing and stronger bone regeneration.
How similar studies have gone: Previous work suggests metformin can promote bone-forming activity in stem cells, but translating this to injectable scaffolds for craniofacial bones is still being explored.
Where this research is happening
-
Ohio State University
Columbus, United States Active
Researchers
- Principal investigator: Schneider, Abraham — Ohio State University
- Study coordinator: Schneider, Abraham
Related research
Other NIH-funded projects on the same topics.
-
Understanding how trinucleotide repeat expansions cause disease
A research project at Ohio State University is exploring how tiny DNA repeats become unstable and drive neurological and muscular diseases, with potential implications for future therapies.
-
Pediatric Prehospital Airway Resuscitation for Critically Ill Children
This grant tests the best way for paramedics to manage breathing tubes and other airways in seriously ill children before they reach the hospital.
-
From Social Breakups to Brain Changes in Alzheimer’s and Related Dementias
This grant explores how losing social connections may trigger brain changes and inflammation linked to Alzheimer’s disease and related dementias.
-
Understanding why patients with blood cancers start and stick with oral cancer medicines
A study to learn what helps or hinders Black patients with blood cancers in starting and continuing their prescribed oral cancer medicines.
-
How sex and hormones affect alcohol's impact on sleep in adults
This study tests how sex and hormone changes influence how alcohol disrupts sleep in healthy adults, with a focus on women aged 21-45.
-
Natural products to block IL-8 signaling and prevent Barrett's Esophagus from turning into esophageal cancer
A搜索-friendly plan to use safe natural compounds to interrupt a key inflammatory signal (IL-8) and stop Barrett’s esophagus from turning into esophageal cancer in people with GERD.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.