Condition
Traumatic Brain Injury clinical trials and research
As of November 12, 2026, Find a Trial lists 131 Traumatic Brain Injury clinical trials that are recruiting, at sites in 31 countries (most in United States (79), China (12), Canada (6)). By phase: Phase 2 (14), Phase 3 (4), Phase 4 (4), Phase 1 (2). The most active sponsors are Kessler Foundation (5), NYU Langone Health (4), University of Pittsburgh (4). There are also 282 NIH-funded research projects on Traumatic Brain Injury, with $117.0 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 131Clinical trials
- 282NIH research projects
- 31Countries
Newest Traumatic Brain Injury clinical trials
All recruiting trials (131)
-
PIONEER-Prognosis: Using biomarkers and wearables to forecast recovery after mild traumatic brain injury
This study tests whether blood biomarkers, health data from records, and wearables can help predict how people recover after a mild traumatic brain injury treated in the emergency department.
-
HBOT to see if it helps cognition and well‑being in first responders with prior brain injury
This study tests whether 40 hyperbaric oxygen therapy sessions can improve thinking skills and post-concussion symptoms in current or former first responders with a history of brain injury.
-
Depth Electrode Monitoring after Traumatic Brain Injury
This study tests adding a depth electrode with continuous brain monitoring during external ventricular drain placement in adults with traumatic brain injury to see if cortical reverberation signals can be tracked safely.
-
Understanding growth hormone deficiency after a brain injury in adults
This observational study tests whether growth hormone deficiency affects quality of life and symptoms in adults with traumatic brain injury and whether GH replacement helps after 12 weeks.
-
Electrical stimulation-assisted exercise for people with lower limb paralysis
This study tests whether adding electrical stimulation during exercise can improve leg muscle strength and endurance for people with paralysis.
-
ZEPU-2000 robotic rehab for arm and leg weakness
This trial tests whether adding ZEPU-2000A, ZEPU-2000D, and ZEPU-2000E robotic rehabilitation to usual therapy helps adults with arm/leg movement problems from stroke, incomplete SCI, TBI, or related conditions.
-
ZEPU-SG1PLUS Hand Training with Robotic Rehab for Arm Problems
A small study tests whether adding the ZEPU-SG1PLUS robotic hand trainer to standard rehab is safe and helps people with arm problems after stroke, spinal cord injury, brain injury, or orthopedic injuries.
-
Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD
This study tests whether benefits from HBOT persist over time for veterans with brain injury or related conditions.
-
Dual-Site Ear Nerve Stimulation for Severe Brain Injury-Related Coma
This study tests a gentle, non-invasive stimulation on the left ear to try to help some people in coma due to severe traumatic brain injury regain awareness.
-
Brain tissue bank for traumatic brain injury patients undergoing contusion removal
This study collects brain tissue discarded during surgery for contusions in adults with traumatic brain injury to see if molecular changes relate to injury progression and recovery.
-
Home-based vision training guided by brain imaging
This study tests whether at‑home, image-guided visual training can improve visual field function for adults with stroke-related vision loss.
-
Neutral fluid balance in adults with traumatic brain injury (LIMIT-TBI)
This study tests whether keeping daily fluid balance around zero (within 500 mL) for the first 5 days in the ICU is feasible and safe for adults with traumatic brain injury.
-
Emotional Awareness Training for Adults After Moderate to Severe TBI
This study tests two emotional health training programs to see which helps adults with moderate to severe traumatic brain injury feel better emotionally.
-
Brain blood flow and brain regulation in critically ill kids
This study tests how blood flow in the brain behaves in critically ill children using a noninvasive ultrasound (TCD) to see if brain autoregulation patterns relate to outcomes.
-
See if Man Therapy helps reduce problematic anger in male service members with or without a mild TBI
This trial tests whether the Man Therapy online program can lower problematic anger in male military members who screen positive for anger, compared to a waitlist.
-
Bilateral cervical sympathetic blocks with optional integrative therapy for Special Operations veterans with PTSD and trauma-related symptoms
This project will try bilateral cervical sympathetic blocks (BCSB), with or without added structured integrative therapy, to see if they reduce PTSD, TBI, and other trauma-related symptoms in Special Operations veterans.
-
Blood test to help diagnose, predict outcomes, and monitor traumatic brain injury in adults
This project will try a blood test to help diagnose and predict outcomes for adults with non-penetrating traumatic brain injury and to monitor for secondary problems while they are hospitalized.
-
Median nerve stimulation to improve thinking after recent traumatic brain injury
This trial will test whether noninvasive median nerve stimulation can help improve thinking, memory, and attention in adults who have cognitive problems soon after a traumatic brain injury.
-
Spatial StimelMD for upper-limb recovery after stroke or traumatic brain injury
This trial will test whether adding the Spatial StimelMD device to standard rehabilitation helps adults with upper-limb weakness after stroke or traumatic brain injury improve arm movement.
-
Noninvasive neuromodulation for people with traumatic brain injury and healthy volunteers
We will try a noninvasive radioelectric neuromodulation (REAC) treatment to see if it changes brain waves in people with diffuse axonal injury after severe TBI and in healthy volunteers.
-
Using carbon dioxide to promote brain waste clearance
This trial will test whether brief, controlled increases in inhaled carbon dioxide help move proteins from the brain into the blood in adults with and without a history of traumatic brain injury.
-
Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI
This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.
-
Remote brain stimulation and cognitive training to improve thinking after TBI in seniors
This test will see if combining at-home transcranial direct current stimulation (tDCS) with computer-based cognitive training improves attention, memory, and decision-making in veterans aged 65 and older who had a mild TBI.
-
Metabolomic profiling to find blood markers for severe traumatic brain injury
This project will test whether patterns of small molecules in the blood can distinguish adults with severe TBI from injured patients without brain injury.
-
Xeomin injections for migraines after traumatic brain injury versus anomalous health incidents
This project will test if Xeomin injections reduce migraine symptoms in adults with a history of traumatic brain injury or an anomalous health incident.
-
Hypnosis to improve attention and reduce fatigue in stroke, TBI, and MS
This trial tests whether adding hypnosis to standard rehab can help adults with stroke, traumatic brain injury, or multiple sclerosis improve attention and feel less fatigued.
-
Comparing Ceriter Stride-One smart insoles with GRAIL gait measurements
We will test whether Ceriter Stride-One pressure-sensitive insoles give the same gait measurements as the GRAIL system for people with stroke, incomplete spinal cord injury, or acquired/traumatic brain injury who can walk independently for at least six minutes.
-
How moderate-to-severe brain injury affects walking and navigation in busy virtual environments
We will test whether people with moderate-to-severe traumatic brain injury navigate and walk differently in realistic virtual environments compared with healthy adults.
-
STRATAFIX sutures for closing cranial and spine surgical wounds
This project will test STRATAFIX sutures for closing cranial and spine surgical wounds in adults to learn about long-term safety and healing.
-
TBI-RECOVER in Outpatient Substance Use Treatment
This trial tests whether the TBI-RECOVER program can help people with a substance use disorder who have a brain injury, by improving retention in treatment and managing cognitive and behavioral challenges.
-
Methylprednisolone for moderate to severe traumatic brain injury
This trial tests whether a 5-day course of methylprednisolone helps adults with moderate to severe traumatic brain injury recover better than placebo.
-
Noninvasive ear stimulation to improve hearing speech in noisy places
This will test whether gentle electrical stimulation of the ear can help people with traumatic brain injury hear speech more clearly in noisy environments.
-
Sleep problems and recovery after a traumatic brain injury
This project will try to see if sleep problems measured after a traumatic brain injury predict later mental health and how well adults recover their day-to-day activities.
-
Improving vision after brain injury
It tests whether gentle brain stimulation (transcranial random noise stimulation) plus visual training can help adults with homonymous hemianopia regain some of their lost visual field.
-
Semi-elemental tube feeding to improve gut tolerance after severe traumatic brain injury
This will test whether starting semi-elemental tube feeding within 48 hours reduces gastrointestinal intolerance in adults with severe traumatic brain injury.
-
Targeting the plantaris tendon during surgery to correct ankle equinus in children
This trial tests whether cutting the small plantaris tendon, together with standard calf-lengthening surgery, helps children aged 4–17 with ankle equinus walk and use their feet better.
-
Jianmin Daopeng Angong Niuhuang Wan to help recovery after traumatic brain injury
This tests whether Jianmin Daopeng Angong Niuhuang Wan (with lab-grown cow bile) helps adults who recently had a traumatic brain injury regain consciousness and neurological function.
-
Stimulating the motor thalamus and surface cortex to improve movement and speech
This test tries brief electrical stimulation of the motor thalamus (VOP/VIM) and nearby cortex during DBS surgery to see if it improves movement, grip strength, and speech in people having DBS for Parkinson's disease, essential tremor, stroke, or brain injury.
-
Motor thalamus deep brain stimulation to improve movement and speech
This trial will test turning deep brain stimulation on and off in adults who already have DBS implants for movement disorders to see if stimulation improves arm and hand movement, facial movement, speech, and swallowing.
-
Overground VR Gait Rehab for Traumatic Brain Injury
A VR-based gait training program is being tested to see if it improves real-world walking for people with traumatic brain injury compared with a non-immersive, treadmill-based VR therapy.
-
Predicting severe traumatic brain injury events
This study is testing a new computer method to see if it can predict serious brain injury events in patients before they happen, so doctors can act quickly to help prevent more damage.
-
Understanding heart issues after brain injuries
This study is trying to understand how brain injuries can cause heart problems and see if there are ways to help patients with these issues.
-
Transcranial light therapy for older adults with traumatic brain injury
This trial will test whether near-infrared light applied to the forehead can increase prefrontal blood flow and improve thinking skills in people aged 55–85 who had a moderate non-penetrating TBI one to two years ago.
-
Using prismatic adaptation and serious games for cognitive rehabilitation in traumatic brain injury
This study is testing if using special glasses and fun games can help people with traumatic brain injury improve their thinking skills better than regular rehab methods.
-
Balance reactions to moving visual patterns in people with concussion and other dizziness
This project will test whether spinning visual patterns shown on a rotating disk or in virtual reality cause balance problems and dizziness in adults with recent concussion or other ongoing dizziness compared with healthy people.
-
Preventing seizures in traumatic brain injury using two medications
This study tests which of two medications, levetiracetam or lacosamide, is better at preventing seizures in people with moderate to severe traumatic brain injuries.
-
High-definition non-invasive brain stimulation for word-finding problems after chronic traumatic brain injury
This trial tries short sessions of non-invasive high-definition transcranial direct current stimulation (HD-tDCS) to see if they help adults with long-term traumatic brain injury who have trouble finding words and remembering things.
-
SENSE device for detecting brain bleeds after traumatic brain injury
This research will test whether the SENSE device can detect intracranial bleeding in adults with traumatic brain injury and compare readings to healthy control subjects.
-
Evaluating hyperbaric oxygen therapy for traumatic brain injury
This study is testing if hyperbaric oxygen therapy is safe and helps adults with traumatic brain injury improve their daily functioning and social activities over two years.
-
Cryoneurolysis for shoulder pain and spasticity management
This study tests if a new cold treatment for shoulder pain can help people with hemiplegia feel better and move better compared to the usual botulinum injections.
-
Using cranial ultrasound to detect brain injuries in children
This study is testing if a special type of ultrasound can help doctors find serious brain injuries in children with head trauma without using radiation.
-
Using noninvasive nerve stimulation to improve cognitive recovery after brain injury
This study is testing if a noninvasive nerve stimulation treatment can help people with mild to moderate brain injuries improve their thinking skills.
-
NEUROBALANCE training to improve balance after traumatic brain injury
This study will test whether combining robotic balance training with noninvasive brain stimulation helps adults with chronic traumatic brain injury who still have balance problems.
-
Hyperbaric oxygen therapy for veterans with traumatic brain injury
This study is testing if hyperbaric oxygen therapy can help veterans and active military personnel with mild to moderate traumatic brain injuries feel better and reduce symptoms of PTSD.
-
Improving cognitive function in older veterans with traumatic brain injury
This study is testing a new program that combines exercise, brain training, and lifestyle coaching to see if it can help older veterans with traumatic brain injuries improve their thinking skills.
-
Rapid treatment for PTSD using brain stimulation
This study is testing a quick brain stimulation treatment for people with PTSD to see if it can help reduce their symptoms in just one week.
-
Improving sleep for Veterans with traumatic brain injury, PTSD, and chronic pain
We will try morning bright light therapy at home to improve sleep for Veterans who have TBI, PTSD, and chronic pain.
-
Training using virtual reality to improve walking and balance after brain injury
This study is testing whether virtual reality training can help people with brain injuries improve their walking and balance better than standard care.
-
Wearable ankle robot to promote neuroplasticity after traumatic brain injury
A wearable ankle rehabilitation robot is tested in adults with acute traumatic brain injury to help regain movement using guided, game-based and feedback-enabled training, even for those with little or no motor output.
-
Crainio non-invasive intracranial pressure monitor for traumatic brain injury
This project will test whether the Crainio device can non‑invasively detect raised intracranial pressure in adults with traumatic brain injury by comparing its readings to standard invasive monitors.
-
Comparing treatments for acute traumatic brain injury in hospitals
This study is testing different treatments for people with acute traumatic brain injuries in hospitals to see which ones work best for recovery.
-
Investigating brain activity and consciousness in patients with severe brain injuries
This study is testing a new way to monitor brain activity in patients with severe brain injuries to see if it can help doctors understand their level of consciousness and improve their treatment.
-
Non-invasive measurement of brain pressure in patients with traumatic brain injury
This study is testing a new non-invasive device to measure brain pressure in patients with traumatic brain injury to see if it can replace the need for more risky surgical methods.
-
Using inhaled isoflurane for sedation in patients with severe head trauma
This study is testing if using inhaled isoflurane for sedation can safely help patients with severe head injuries without the risks of traditional sedatives.
-
Treating light sensitivity after traumatic brain injury with Botox
This study is testing if Botox can help people with light sensitivity after a traumatic brain injury feel better and improve their quality of life.
-
Treatment of acute epidural hematoma using middle meningeal artery embolization
This study is testing if a new procedure using middle meningeal artery embolization can help people with acute epidural hematoma recover better than standard treatment.
-
Testing Angiotensin (1-7) for treating moderate to severe traumatic brain injury
This study is testing if a new drug called Angiotensin (1-7) can help people with moderate to severe traumatic brain injuries recover better over 21 days.
-
Improving recovery after surgery for neurocritical care patients
This study tests a new recovery plan for patients in neurocritical care after surgery to see if it helps them heal faster and have fewer complications compared to standard care.
-
Communication through a brain implant for people with locked-in syndrome
This study is testing a brain implant that helps people with locked-in syndrome communicate by translating their brain activity into messages.
-
Assessing ventilatory parameters in patients with acute neurological injuries
This study is trying to see how different breathing machine settings affect the brain health of adults with serious neurological injuries like strokes or brain trauma.
-
Improving rehabilitation care for traumatic brain injury patients with community health services
This study is testing if adding community health workers to help support people with traumatic brain injury and their families can make their transition from hospital to home easier and improve their recovery.
-
Robotic balance training for improving postural control after brain injury
This study tests if robotic balance training can help people who have had a brain injury improve their balance and reduce their risk of falling.
-
Graded aerobic exercise for mild traumatic brain injury
This study is trying out a special exercise program to see if it can help people with lingering symptoms after a mild brain injury feel better and improve their overall health compared to those getting regular rehab.
-
Virtual wellness program for individuals with traumatic brain injury
This study is testing a virtual wellness program to see if it can help people with traumatic brain injury improve their emotional, physical, and nutritional health.
-
Using stem cells from umbilical cord to treat brain injuries
This study is testing if stem cells from umbilical cords can help people with traumatic brain injuries recover better by reducing inflammation in the brain.
-
Using Virtual Reality to Help Children Recover from Brain Injuries
This study is testing whether using virtual reality can help children aged 8-12 recover better from mild to moderate brain injuries by improving their attention and daily living skills.
-
Automated virtual reality therapy for eye recovery after brain injury
This study tests a new virtual reality therapy to see if it can help veterans with vision problems after a brain injury feel better.
-
Using advanced MRI to study brain metabolism in traumatic brain injury
This study is testing a new type of MRI to see how brain metabolism changes in people with traumatic brain injury compared to healthy individuals and those with a different brain condition.
-
Preventing frailty in older adults with multiple health issues
This study is trying to see how muscle health affects frailty in older adults with multiple health issues to improve their rehabilitation and treatment options.
-
Baricitinib for moderate-to-severe intracerebral bleeding and contusions after head injury
This will test whether giving baricitinib soon after a head injury helps adults with moderate to severe brain bleeding or contusions recover better.
-
Examining cognitive and vascular functioning after traumatic brain injury
This study is trying to see how brain injuries and heart health are connected to thinking problems in Service Members and Veterans.
-
Program to boost physical activity after traumatic brain injury
This study is testing a 10-week program that helps people recover from a serious brain injury by boosting their physical activity through therapy sessions and a mobile app.
-
Using stem cells from fat to treat chronic traumatic brain injury
This study is testing if infusing stem cells taken from fat can help people with chronic traumatic brain injuries feel better and improve their brain function.
-
Implementing an online emotion regulation program for traumatic brain injury
This study tests which training method helps clinicians better deliver an online program to help people with traumatic brain injury manage their emotions.
-
Using Continuous Passive Motion to Prevent Heterotopic Ossification
This study is trying out a special movement therapy to see if it helps prevent bone growth problems in ICU patients with brain or spinal injuries.
-
Evaluating blood tests to rule out brain injuries after mild trauma
This study is testing if two blood tests can help doctors rule out serious brain injuries in people who have had a mild head injury.
-
Remote neuropsychological assessments for patients with neurological disorders
This study is testing a new online way to check brain function in patients with neurological disorders who have trouble getting to appointments.
-
Using Sildenafil to Improve Blood Flow in Chronic Traumatic Brain Injury
This study is testing whether sildenafil can improve blood flow in people with chronic traumatic brain injury to see if it helps their symptoms.
-
Assessing brain changes after traumatic brain injury over three years
This study looks at how brain tissue changes over three years in people who have had a traumatic brain injury compared to healthy individuals.
-
Combining rehabilitation techniques to help individuals with traumatic brain injury
This study is testing if combining a special memory training with aerobic exercise can help people with moderate-to-severe traumatic brain injury improve their memory and daily functioning.
-
High intensity step training for improving mobility after brain injury
This study is testing different types of training, including high intensity step training and virtual reality, to see if they can help people with brain injuries improve their mobility and balance.
-
Improving sleep for individuals with traumatic brain injury
This study tests a new online therapy program to help people with moderate to severe traumatic brain injury improve their sleep quality compared to standard treatment.
-
Comparing two therapies for insomnia in veterans with traumatic brain injury
This study is testing whether online therapy for insomnia or mindfulness techniques can help veterans with brain injuries sleep better and feel less depressed.
-
Road-to-Recovery: web support for families after a child's traumatic brain injury
This project will try a web-based Road-to-Recovery program to help caregivers of children (3 months–18 years) recovering from complicated mild to severe traumatic brain injury, compared with usual medical care plus online resources.
-
Collecting and analyzing clinical and molecular data in patients with traumatic brain injury
This study is testing if collecting detailed health information and brain tissue samples from patients with traumatic brain injury can help doctors better predict recovery and outcomes.
-
Improving diagnosis of cardiovascular, cancer, and neurological diseases using machine learning
This study is testing if using machine learning can help doctors diagnose heart problems, cancer, and brain injuries faster and more accurately in patients who haven't started treatment yet.
-
Nurse-guided treatment for insomnia in patients recovering from brain injuries
This study is testing whether a nurse-guided treatment for insomnia can help people recovering from brain injuries sleep better and improve their mood and thinking.
-
Developing a decision rule for safely assessing head injuries in patients on blood thinners
This study is testing a new guideline to help doctors safely determine if patients on blood thinners have a serious head injury after a bump to the head.
-
Using real-time brain monitoring to improve treatment for severe traumatic brain injury
This study is testing if real-time brain monitoring can help doctors provide better care for patients recovering from severe traumatic brain injuries by identifying specific brain issues that need targeted treatment.
-
Exploring neuroplasticity through proprioceptive rehabilitation with muscle vibrations
This study is testing if using muscle vibrations can help improve brain recovery and movement in people who are healing from a stroke or brain injury.
-
Enhancing cognitive training for veterans with traumatic brain injury
This study is testing if combining a special brain training program with different types of brain stimulation can help veterans with mild traumatic brain injuries improve their thinking skills.
-
Using Pharyngeal Electrostimulation to Treat Swallowing Difficulties from Neurological Conditions
This study is testing a new device called Phagenyx® to see if it can help people with swallowing difficulties caused by neurological conditions like stroke or brain injury.
-
Using brain-computer interfaces to control assistive devices for motor recovery
This study tests whether using brain-computer interfaces can help people with motor disorders control assistive devices better and improve their movement skills.
-
Using ketamine to treat severe acute brain injuries
This study is testing if S-ketamine can help people with severe brain injuries feel better and improve their recovery compared to a placebo.
-
Enhancing memory through amygdala stimulation
This study is testing if stimulating a part of the brain called the amygdala can help improve memory in people with epilepsy who are being monitored for seizures.
-
Comparing two group wellness programs for people with brain injuries and their caregivers
This study is testing two different online wellness programs to see if they can help people with brain injuries and Alzheimer's disease, along with their caregivers, feel better and improve their quality of life.
-
Using electric stimulation to improve memory in veterans with brain injuries
This study is testing if a special type of brain stimulation can help veterans with mild brain injuries improve their memory and thinking skills.
-
Monitoring biomarkers in traumatic brain injury treatment
This study is trying to see if tracking certain biological markers can help doctors find the best treatments for people with severe traumatic brain injuries.
-
A platform for collecting health data on ME/CFS and Long Covid
This study is trying to collect health information from adults with ME/CFS and Long Covid to help researchers better understand these conditions and improve future treatments.
-
Observing brain responses to music and language in unconscious patients with acute brain injuries
This study is trying to see if listening to music and language can help unconscious patients with acute brain injuries recover better by looking at their brain activity.
-
Assessing brain health in retired professional football players
This study is trying to see how playing professional football affects brain health in retired players compared to others who didn't play football.
-
Using Erythropoietin Alfa to Improve Outcomes in Critically Ill Trauma Patients
This study is testing if a medication called epoetin alfa can help critically ill trauma patients recover better and reduce the risk of death or severe disability.
-
Using cannabidiol to treat PTSD and traumatic brain injury symptoms
This study is testing if taking cannabidiol (CBD) can help people with PTSD, some of whom also have mild brain injuries, feel better compared to a placebo.
-
Assessing blood clotting disorders in traumatic brain injury patients
This study is trying to see how blood clotting problems in people with traumatic brain injuries affect their recovery and outcomes after they arrive at the hospital.
-
Early intramuscular tranexamic acid for older adults with mild head injury
This will test whether an early intramuscular injection of tranexamic acid can reduce brain bleeding, disability, death, and later dementia in people aged 50 and over with symptomatic mild head injury.
-
Monitoring intracranial pressure to assess patient outcomes
This study is testing if continuous monitoring of pressure inside the skull can help doctors understand how well patients with serious brain injuries are doing and predict their recovery.
-
Identifying factors that predict recovery of consciousness in brain injury patients
This study is trying to find out what factors help predict how well patients with brain injuries will recover their awareness after they start early rehabilitation.
-
Improving memory and attention in adults with brain injuries
This study tests if a computer-based brain training program can help adults with brain injuries improve their memory and attention skills.
-
Using brain stimulation to improve thinking skills in people with mental health conditions
This study is testing if a brain stimulation treatment can help improve thinking skills in people with mental health conditions like depression, bipolar disorder, and ADHD.
-
Using egg yolk powder to treat severe traumatic brain injury
This study is testing if an egg yolk powder can help improve recovery for people with severe traumatic brain injuries when added to their regular treatment.
-
Exploring the effects of branched chain amino acids on sleep in veterans
This study is testing if taking branched chain amino acids can help improve sleep and thinking skills in veterans who have had a traumatic brain injury.
-
New methods to diagnose and monitor light sensitivity
This study is testing new ways to diagnose and track light sensitivity and headaches in people with conditions like traumatic brain injury and migraines using advanced technology.
-
Preventing blood clots in patients with severe traumatic brain injury
This study is testing whether using a combination of special leg devices and blood thinners can better prevent blood clots in people with severe brain injuries without causing more bleeding in the brain.
-
Long-term effects of rehabilitation after traumatic brain injury and stroke
This study is trying to see how different types of rehabilitation after a traumatic brain injury or stroke affect people's long-term recovery and quality of life over the next 10 years.
-
Understanding brain activity after severe traumatic brain injury
This study is trying to understand brain activity in patients with severe traumatic brain injuries to see how certain brain changes might affect recovery and help find better treatments.
-
Evaluating retinal imaging for neurodegenerative diseases
This study is testing if special eye scans can help spot early signs of neurodegenerative diseases like Alzheimer's and Parkinson's in people.
-
Non-invasive nerve stimulation to improve sleep in PTSD and TBI patients
This study is testing two types of nerve stimulation to see if they can help veterans with PTSD and mild brain injuries sleep better.
-
Rehabilitation of vision after brain injury
This study is testing a training program to help people who have had brain injuries, like strokes, improve their vision and quality of life.
-
Treatment for neurologic disorders using stem cells
This study is testing whether using stem cells from patients' own bone marrow can help improve brain and nerve function in people with serious neurologic disorders that don't respond well to regular treatments.
-
Mobile health system for managing chronic health conditions
This study tests a mobile health system that helps people with chronic conditions like spinal cord injuries and cerebral palsy manage their health better by using apps for reminders and tracking symptoms.
-
Hyperbaric oxygen treatment for severe brain injury
This study is testing different ways of using hyperbaric oxygen treatment to see if it can help people with severe brain injuries feel better.
NIH-funded research (newest 40 of 282)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
-
AI-enhanced virtual reality tool to support remote emergency brain surgery training in Tanzania
A new AI-powered virtual reality tool helps non-experts in low-resource areas get real-time remote guidance for emergency traumatic brain injury surgery.
-
How head injury affects the heart and blood vessels
This project aims to find out whether traumatic brain injuries make people more likely to develop hardened arteries and heart problems, especially among veterans.
-
Neural targets for improving function in Veterans with alcohol use disorder and mild brain injury
This project tests a targeted brain-stimulation approach to help Veterans who have both alcohol use problems and mild traumatic brain injury improve daily functioning.
-
How head injuries affect the heart and blood vessels
This project is looking at whether past traumatic brain injuries cause changes in blood vessels and raise the risk of heart disease for people who have had head injuries.
-
Keeping oxygen in the injured brain after severe head trauma
This project uses a small brain oxygen monitor to guide ICU care for people with severe traumatic brain injury in hopes of improving recovery.
-
How head injuries affect Parkinson's over time
Researchers will follow people with Parkinson's disease to learn how past mild-to-moderate head injuries relate to thinking, mood, movement, brain changes, and quality of life.
-
Brain oxygen monitoring to help recovery after severe head injury
This project uses a brain oxygen sensor to guide ICU care for people with severe traumatic brain injury.
-
Keeping the brain better oxygenated after severe head injury
This trial compares using a small brain oxygen sensor plus targeted treatments to standard ICU care for people with severe traumatic brain injury to reduce low brain oxygen and help recovery.
-
Brain oxygen monitoring to improve recovery after severe head injury
This project compares standard intracranial pressure care with added brain-tissue oxygen monitoring to help people with severe traumatic brain injury avoid low brain oxygen and improve recovery.
-
Chronic Traumatic Brain Injury and Epilepsy: Finding New Ways to Stop Seizures
This grant explores how repetitive and complex brain injuries lead to epilepsy and cognitive problems, with a focus on Veterans suffering from traumatic brain injury.
-
Optimizing brain chemical signaling to help people after traumatic brain injury
A small study will test whether a drug called modafinil can improve thinking, attention, and emotional regulation in adults who have had a traumatic brain injury.
-
Glycan signals in neutrophils and pneumonia risk after brain injury
This grant explores how immune Cells in people with brain injury may become more prone to pneumonia due to changes in sugars on their cells, with the goal of preventing infections.
-
Biological mechanisms behind worsening brain decline after older adults’ mild brain injury
This research looks at why some older adults experience dementia-like decline after a mild traumatic brain injury and how it links to Alzheimer’s disease.
-
Mild Traumatic Brain Injury: A High-Tech Look Inside the Brain with Diffusion MRI
Researchers are using advanced brain imaging to find biological clues in people who have mild traumatic brain injuries.
-
Traumatic Brain Injury Across Life: How TBI Relates to Later Dementia Risk
This study looks at how head injuries over a person’s life affect their chances of developing Alzheimer's disease or related dementias later on.
-
New noninvasive brain-monitoring tech to help kids after traumatic brain injury
A new noninvasive optical device is being developed to detect brain problems early in children who have suffered a traumatic brain injury.
-
Microglia-derived vesicles and brain-artery inflammation after brain injury
This NIH grant explores how tiny brain cell packages from microglia after a brain injury may drive inflammation and accelerate artery disease, potentially helping people who’ve had a traumatic brain injury.
-
Community-based aerobic exercise for adults with moderate to severe traumatic brain injury
A year-long aerobic exercise program is being tested to see if it can improve thinking, mood, and quality of life for adults aged 45–80 who have had moderate to severe traumatic brain injury.
-
How neuromodulation may help headaches after a mild brain injury
A small study tests whether stimulating the brain with a noninvasive technique can lessen persistent headaches in people who recently had a concussion.
-
Kuishi-TBI App: Mobile care tool for traumatic brain injury in Tanzania
A mobile health app to help triage, guide treatment, and educate TBI patients in Tanzania and similar settings.
-
Caregiver Wellness support for adults after moderate-to-severe traumatic brain injury
A caregiver-focused program delivered by web and phone helps family members of adults with moderate-to-severe TBI feel better and support the person they care for.
-
The role of Slc25a1 in brain immune cell activation after traumatic brain injury
This project looks at how a specific cell “gatekeeper” protein (Slc25a1) affects inflammatory brain cells after a traumatic brain injury, with the aim of finding ways to reduce long-term damage.
-
NOX2 and microglia in brain injury: a potential path to better recovery
After a traumatic brain injury, harmful brain inflammation driven by microglia may lead to ongoing damage; this grant tests a targeted approach to calm microglia by focusing on NOX2 to protect brain function.
-
New ways to treat chronic pain after mild brain injuries
A research team is studying why some people develop long-lasting pain after a mild head injury and how brain inflammation contributes to it.
-
Retraining brain pathways to boost thinking after a mild head injury
A clinical trial tests a brain-training program to improve thinking and memory in people who have had a mild traumatic brain injury (mTBI).
-
Oxidized brain fats after head injuries in children
Researchers are looking at how specific damaged brain fats after serious head injuries in children may cause brain cell loss and point to better treatments.
-
Two treatment approaches for severe head injuries in children in Latin America
It compares care guided by pressure monitors inside the skull to care guided by scans and exams for children and teens with severe head injuries.
-
Careful comparison of inpatient rehab methods after traumatic brain injury
A large study will follow people with moderate to severe brain injury to see which inpatient rehab practices help them recover best.
-
How ongoing sleep problems affect memory and thinking after a head injury
Looking at whether long-term sleep problems make it harder for people with traumatic brain injury to regain memory and thinking skills.
-
Lipid imaging in brain injury to map damaged cells and lipids
A study looking at brain injury to map where lipids change and which cells are affected, using advanced imaging to guide future therapies.
-
No REST for 5-HT Neurons After Brain Injury
This grant explores how traumatic brain injury changes serotonin-producing neurons and aims to find ways to improve mood and social behavior after injury.
-
Cis-proline tau toxicity in brain injury and dementia
Aims to understand how a specific toxic form of tau protein appears after brain injury and contributes to Alzheimer’s-related dementia, and how early intervention might protect neurons.
-
Bidirectional brain-gut links in trauma-related brain injury health
A study in people (and animal models) explores how brain injury and gut health influence each other to affect long-term brain function.
-
Human Schwann Cell–Derived Exosome Therapy for Traumatic Brain Injury
A new treatment using tiny particles from human nerve cells given after brain injury to help protect the brain and improve recovery.
-
Gut signals that affect brain injury health
This project looks at how gut serotonin signaling may influence outcomes after traumatic brain injury and could reveal new ways to help people recover.
-
Fecal microbiome therapy to help older adults recover after brain injury
A trial explores giving a healthy gut microbiome to help people, especially older adults, recover better after a traumatic brain injury.
-
Trauma, the gut, and the brain: how gut microbes and microglia affect brain injury
A study to understand how gut bacteria and brain immune cells interact after a traumatic brain injury and how this might influence recovery.
-
Understanding how brain immune signals after injury affect inflammation and brain function
This grant studies how brain immune cells called microglia react to traumatic brain injury and whether their interferon signals drive long-term inflammation and cognitive problems.
-
Mesenchymal Stem Cell–Derived Vesicles to Help Traumatic Brain Injury
Aims to test a therapy made from stem-cell–derived vesicles given as an intranasal spray to improve brain function after traumatic brain injury in mice, focusing on both early and later treatment windows.
-
Cell-level changes in mitochondria after brain injury that may drive neurodegeneration
A new NIH grant looks at how mitochondrial problems after brain injury could set off long-term brain degeneration similar to Alzheimer’s disease.
Related topics
Quick answers
How many Traumatic Brain Injury clinical trials are recruiting right now?
131, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 31 countries. The most sites are in United States (79 trials), China (12 trials), Canada (6 trials), France (5 trials), Italy (4 trials). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 14, Phase 3: 4, Phase 4: 4, Phase 1: 2. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.