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Comparing treatments for acute traumatic brain injury in hospitals

Comparative Effectiveness of Intervention in Multi-level Hospitals for Acute Traumatic Brain Injury: a Prospective, Multicenter, Observational Cohort Study

Beijing Tiantan Hospital · NCT06429774

This study is testing different treatments for people with acute traumatic brain injuries in hospitals to see which ones work best for recovery.

Quick facts

Study typeObservational
Enrollment2000 (estimated)
Ages1 Year to 89 Years
SexAll
SponsorBeijing Tiantan Hospital (other)
Locations64 sites (Beijing, Beijing Municipality and 63 other locations)
Trial IDNCT06429774 on ClinicalTrials.gov

What this trial studies

This observational cohort study aims to evaluate the effectiveness of various interventions for acute traumatic brain injury (TBI) across multiple hospitals in the Beijing-Tianjin-Hebei region. It will establish a comprehensive database that includes treatment capabilities, patient data, and clinical outcomes, focusing on neuroimaging and rehabilitation prognoses. The study will enroll 2,000 patients under 90 years old with confirmed TBI and assess outcomes such as the Extended Glasgow Outcome Score and various mental health questionnaires over a 12-month period. The findings will help optimize treatment strategies and establish collaborative protocols for better patient care.

Who should consider this trial

Good fit: Ideal candidates are patients aged 1 to 89 years with clinically confirmed traumatic brain injury.

Not a fit: Patients aged 90 years and older, those with serious concomitant illnesses, or those unable to complete follow-up assessments may not benefit from this study.

Why it matters

Potential benefit: If successful, this study could lead to improved treatment protocols and better outcomes for patients with traumatic brain injury.

How similar studies have performed: Other studies have shown success in optimizing treatment protocols for traumatic brain injury, indicating that this approach has potential for meaningful advancements.

Eligibility criteria

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Patient (1 years to 89 years) presenting with clinical symptoms of traumatic brain injury
* Traumatic brain injury verified on cranial computed tomography or magnetic resonance imaging
* Written informed consent from patients or their next of kin according to the patient's cognitive status

Exclusion Criteria:

* patients ≥90 years of age
* patients who did not accept follow-up visits or were unable to complete follow-up assessments
* patients with incomplete information
* patients who did not obtain written informed consent
* patients with concomitant cancer or other serious illnesses

Where this trial is running

Beijing, Beijing Municipality and 63 other locations

+14 more sites — see ClinicalTrials.gov for the full list.

Study contacts

How to participate

  1. Review the eligibility criteria above with your treating physician.
  2. Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
  3. Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.

View on ClinicalTrials.gov →

Conditions: Traumatic Brain Injury, Beijing-Tianjin-Hebei region, Database, Comparative effectiveness of intervention, Clinical Treatment Guideline

Last reviewed 2026-05-15 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.