Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This interventional Phase 2 study enrolls veterans who completed a full HBOT protocol to see if the cognitive and mental health gains last beyond treatment and whether delayed improvements appear months later. Participants will undergo follow-up assessments 12 weeks after finishing HBOT to evaluate durability of outcomes related to cognition, PTSD, anxiety, depression, and daily functioning. The study aims to clarify the long-term trajectory of HBOT effects and inform future treatment recommendations.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. At least 18 years of age.
2. Veteran status
3. Clinically diagnosed with a mTBI, PCS, PTSD, Anxiety, or Depression disorder.
4. Successfully completed the parent Hyperbaric Oxygen Therapy (HBOT) intervention, consisting of the full study treatment protocol (40 HBOT sessions).
5. Willing and able to read, understand, and provide written informed consent for participation in the 12-week follow-up study. Additionally, the Participant has clear consciousness and the ability to express self-feelings independently.
6. Completed cognitive and psychological measurements.
7. Clinical diagnoses cause significant impairment in social or occupational functioning or some other functional capacity.
8. Stability on any current psychoactive medications (antidepressants, anti-anxiety medications, antipsychotics, stimulants, and mood stabilizers).

Exclusion Criteria:

1. Acute medical illness or infection
2. Severe or unstable physical disorders or major cognitive deficits
3. Current manic, psychotic episodes, or serious suicidal ideations
4. Non-English speakers
5. Inability to attend scheduled follow-up visits
6. Significant life events, new neurological injury, or new psychiatric diagnosis or hospitalization occurring after completion of the HBOT intervention that, in the opinion of the investigator, could confound cognitive, psychological, or quality-of-life outcomes.
7. Participation in another interventional clinical study or receipt of a therapeutic intervention following completion of HBOT that could influence cognitive, psychological, or quality-of-life outcomes.

Where it's running

• Summit Hyperbarics and Wellness
  Boise, Idaho, United States Recruiting

Study contacts

• Study coordinator: Troy Nickel, PhD
• Email: tnickel@shwidaho.org
• Phone: 208-813-9541

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.