Graded aerobic exercise for mild traumatic brain injury

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This clinical trial investigates the effects of a graded aerobic exercise program on patients suffering from persistent post-concussive symptoms (PCS) following mild traumatic brain injury (mTBI). It aims to determine if this exercise regimen can reduce symptom burden, improve exercise tolerance, and enhance overall health-related quality of life compared to a control group receiving standard rehabilitation. The study will utilize the Buffalo Concussion Treadmill Test to assess exercise intolerance and will measure autonomic nervous system function through MRI and other tests. Participants will be randomized into either the intervention or control group for a 12-week period.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of mild TBI as defined by the World Health Organization (WHO)
* Diagnosis of PCS based on ICD-10 criteria for a minimum of 3 months to a maximum of 2 years
* Age 18-60 years.
* Reduced tolerance to physical activity/exercise intolerance (self-reported worsening of symptoms such as dizziness, nausea or headache during physical activity and exercise). Or have not yet tried physical activity/exercise after the injury.

Exclusion Criteria:

* Other neurological or severe psychiatric conditions listed in the medical record.
* Heart-lung disease.
* Extremity injuries that prevent physical exercise
* Drug addiction
* Insufficient understanding of the Norwegian language (unable to follow instructions and/or fill in forms).
* Normal BCTT.

Where it's running

• Sunnaas rehabilitation hospital
  Nesoddtangen, Norway Recruiting
• Oslo University Hospital
  Oslo, Norway Recruiting

Study contacts

• Principal investigator: Marianne Løvstad, Professor — Head of psychology
• Study coordinator: Marianne Løvstad, Professor
• Email: mar.lovstad@gmail.com
• Phone: +4793452003

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.