Understanding heart issues after brain injuries

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the neural mechanisms behind cerebrocardiac syndrome (CCS) that can occur following traumatic brain injury (TBI). It aims to explore how TBI affects the autonomic nervous system and contributes to heart complications such as myocardial injury and arrhythmias. By utilizing emerging research in brain connectomics, the study seeks to identify specific brain patterns that may lead to CCS and evaluate potential noninvasive interventions to maintain autonomic balance. The goal is to improve prevention and treatment strategies for patients experiencing CCS after TBI.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with isolated closed head trauma
* Age 18-80 years old
* Admitted to hospital within 24 hours of injury
* Mild or moderate TBI (Glasgow Coma Scale score of 9-15)
* Signed consent form

Exclusion Criteria:

* Severe TBI (Glasgow Coma Scale score of 3-8)
* A history of stroke, TBI, intracranial tumor or surgery in the past 1 year
* A history of coronary heart disease, structural heart disease and other primary heart diseases or suspected cardiac symptoms prior to injury
* Causes of abnormal cardiac biomarkers such as renal insufficiency, severe anemia, sepsis, cardiotoxic drugs and so on
* Not suitable for MRI examinations, such as pregnant women and those with metal implants in the body
* Undergo surgery prior to MRI examinations or cardiac testing

Where it's running

• Shanghai 6th People's Hospital
  Shanghai, China Recruiting
• Shanghai Sixth People's Hospital
  Shanghai, China Recruiting

Study contacts

• Principal investigator: Lai Wei, M.D. — Shanghai 6th Peoples' Hospital
• Study coordinator: Hao Chen, M.D., Ph.D.
• Email: hao.chen@shsmu.edu.cn
• Phone: 8602164369181

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.