Assessing ventilatory parameters in patients with acute neurological injuries
Official title: Baseline Ventilatory Parameters in Patients With Acute Neurological Injury
Run by Ramos Mejía Hospital · NCT06192342 · Data updated 2026-11-12
This study is trying to see how different breathing machine settings affect the brain health of adults with serious neurological injuries like strokes or brain trauma.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 16 Years and up |
| Sex | All |
| Enrollment | 19 (estimated) |
| Sponsor | Ramos Mejía Hospital Academic / other |
| Locations | 1 site (Ciudad Autonoma de Buenos Aires, Buenos Aires) |
| Status | Recruiting |
| Started | May 1, 2024 |
| Main results expected | May 30, 2027 |
| Study ends | June 30, 2028 |
| Registry record updated | August 27, 2026 |
| Trial ID | NCT06192342 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates include adults aged 16 and older with acute neurological injuries requiring mechanical ventilation and without pre-existing lung injuries.
✕Probably not a fit
Patients with chronic obstructive pulmonary disease, pneumothorax, or significant hemodynamic instability may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational study aims to explore the relationship between baseline ventilatory parameters, such as mechanical power and driving pressure, and the neurological status of adult patients with acute neurological injuries requiring mechanical ventilation. It focuses on patients suffering from conditions like stroke, traumatic brain injury, and subarachnoid hemorrhage. By evaluating these parameters, the study seeks to understand how mechanical ventilation may impact neurological outcomes and the potential for ventilator-induced lung injury. The study will assess patients' neurological status using the Glasgow coma scale upon admission.
Why it matters
Potential benefit: If successful, this study could improve the management of mechanical ventilation in patients with acute neurological injuries, potentially leading to better neurological outcomes.
How similar studies have gone: While the specific approach of this study is novel, similar studies have indicated the importance of ventilatory parameters in critically ill patients, suggesting potential for meaningful insights.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: Acute neurological injury in patients ≥ 16 years of age with requiring mechanical ventilation for neurological causes and without baseline lung injury, defined as: normal chest x-ray and adequate oxygenation; PaO2/FiO2 ≥ 300.Neumovent TS and Neumovent Advance respirators will be used. \- Exclusion Criteria: Pneumothorax, or a pleural drainage tube. Hemodynamic instability (mean blood pressure ≤ 65 mmHg) or high doses of inotropes (Norepinephrine \> 0.5 gammas/kilo/minute or equivalent). PaO2/FiO2 \< 80 mmHg. Chronic obstructive pulmonary disease (COPD). Pregnant
Where it's running
-
Roberto Santa Cruz
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina Recruiting
Study contacts
- Principal investigator: Roberto Santa Cruz — Hospital General Ramos Mejia
- Study coordinator: Roberto S Santa Cruz, Dr.
- Email: resc.hrrg@gmail.com
- Phone: +5492966559019
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.