Assessing ventilatory parameters in patients with acute neurological injuries
Baseline Ventilatory Parameters in Patients With Acute Neurological Injury
This study is trying to see how different breathing machine settings affect the brain health of adults with serious neurological injuries like strokes or brain trauma.
Quick facts
| Study type | Observational |
|---|---|
| Enrollment | 19 (estimated) |
| Ages | 16 Years and up |
| Sex | All |
| Sponsor | Ramos Mejía Hospital Academic / other |
| Locations | 1 site (Ciudad Autonoma de Buenos Aires, Buenos Aires) |
| Trial ID | NCT06192342 on ClinicalTrials.gov |
What this trial studies
This observational study aims to explore the relationship between baseline ventilatory parameters, such as mechanical power and driving pressure, and the neurological status of adult patients with acute neurological injuries requiring mechanical ventilation. It focuses on patients suffering from conditions like stroke, traumatic brain injury, and subarachnoid hemorrhage. By evaluating these parameters, the study seeks to understand how mechanical ventilation may impact neurological outcomes and the potential for ventilator-induced lung injury. The study will assess patients' neurological status using the Glasgow coma scale upon admission.
Who should consider this trial
Good fit: Ideal candidates include adults aged 16 and older with acute neurological injuries requiring mechanical ventilation and without pre-existing lung injuries.
Not a fit: Patients with chronic obstructive pulmonary disease, pneumothorax, or significant hemodynamic instability may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could improve the management of mechanical ventilation in patients with acute neurological injuries, potentially leading to better neurological outcomes.
How similar studies have performed: While the specific approach of this study is novel, similar studies have indicated the importance of ventilatory parameters in critically ill patients, suggesting potential for meaningful insights.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: Acute neurological injury in patients ≥ 16 years of age with requiring mechanical ventilation for neurological causes and without baseline lung injury, defined as: normal chest x-ray and adequate oxygenation; PaO2/FiO2 ≥ 300.Neumovent TS and Neumovent Advance respirators will be used. \- Exclusion Criteria: Pneumothorax, or a pleural drainage tube. Hemodynamic instability (mean blood pressure ≤ 65 mmHg) or high doses of inotropes (Norepinephrine \> 0.5 gammas/kilo/minute or equivalent). PaO2/FiO2 \< 80 mmHg. Chronic obstructive pulmonary disease (COPD). Pregnant
Where this trial is running
Ciudad Autonoma de Buenos Aires, Buenos Aires
- Roberto Santa Cruz — Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina (Recruiting)
Study contacts
- Principal investigator: Roberto Santa Cruz — Hospital General Ramos Mejia
- Study coordinator: Roberto S Santa Cruz, Dr.
- Email: resc.hrrg@gmail.com
- Phone: +5492966559019
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.