Condition

Brain Tumor clinical trials and research

• 70Clinical trials
• 70NIH research projects
• 1New in 30 days
• 22Countries

Newest Brain Tumor clinical trials

All recruiting trials (70)

• One-day exercise test to see how brain and body react in epilepsy, cognitive disorders, Parkinson's, dementia, and related conditions

  A one-day study tests how an acute bout of exercise changes brain function and bodily signals in people with certain neurological conditions compared with healthy individuals.

  Recruiting Brigham and Women's Hospital · Boston, Massachusetts · NCT07883720

• Maintenance radiotherapy after standard glioblastoma treatment

  This study tests whether a single 2 Gy maintenance radiotherapy dose after standard treatment is safe and feasible for adults with newly diagnosed glioblastoma.

  Recruiting University of Minnesota · Minneapolis, Minnesota · NCT07831772

• BCB-276 CAR T therapy for DIPG in children and young adults

  This study tests BCB-276, a patient's own CAR T cells against DIPG, after standard radiation, to see if it is safe and can help extend survival.

  Recruiting at 3 sites Phase 2 BrainChild Bio, Inc · Los Angeles, California and 5 other locations · NCT07680439

• Temozolomide safety and effectiveness in adults with Grade III–IV glioma

  This study tests how safe and effective Amitzo temozolomide is in adults with Grade III or IV glioma in Iran, without a control group.

  Recruiting NanoAlvand · Tehran · NCT07675070

• Home-based vision training guided by brain imaging

  This study tests whether at‑home, image-guided visual training can improve visual field function for adults with stroke-related vision loss.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT07635329

• Memantine and raloxifene to protect memory after brain radiation

  This study tests whether adding memantine and raloxifene to brain radiation can help adults preserve memory better than radiation alone.

  Recruiting Phase 2 The University of Texas Health Science Center at San Antonio · San Antonio, Texas · NCT07470606

• Meningioma: How social factors and personal risks relate to health outcomes

  This study tests whether social and personal risk factors help explain differences in health outcomes for adults with meningioma.

  Recruiting University of California, San Francisco · San Francisco, California · NCT07418775

• Gut microbiota in children with suspected brain tumors

  This will test whether stool samples can reveal gut microbiota differences in children aged 3–18 who are suspected of having a central nervous system (CNS) tumor.

  Recruiting Meyer Children's Hospital IRCCS · Florence, Firenze · NCT07417085

• B7-H3 CAR T cells for recurrent brain tumors in kids and young adults

  This early-phase trial tests a personalized CAR T-cell therapy called B7-H3 CAR T for children and young adults with recurrent or progressive brain tumors.

  Recruiting at 2 sites Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 1 other locations · NCT07390539

• Blood biomarkers for treatment-related brain injury in children with brain tumors

  This project will test whether blood plasma biomarkers can show treatment-related brain injury in children with primary brain tumors by comparing those who receive radiotherapy, those who do not, and healthy children of the same age and sex.

  Recruiting Uppsala University · Uppsala · NCT07381959

• Mask-free brain radiotherapy using surface-guided imaging

  We will try using surface imaging so adults receiving fractionated radiotherapy for brain tumors can be treated without the usual thermoplastic mask, with the beam paused if they move.

  Recruiting Cliniques universitaires Saint-Luc- Université Catholique de Louvain · Woluwe-Saint-Lambert, Brussels Capital · NCT07323966

• Cognitive Strategies, Mindfulness & Rehabilitation (C-SMART) versus Brain Health Education and Wellness (BE Well) for adults with brain tumors

  This project will test whether an 8-week individualized telehealth program combining cognitive rehabilitation and mindfulness (C-SMART) helps adults with brain tumors more than an 8-week brain health education video program (BE Well).

  Recruiting Virginia Commonwealth University · Richmond, Virginia · NCT07224503

• Improving vision after brain injury

  It tests whether gentle brain stimulation (transcranial random noise stimulation) plus visual training can help adults with homonymous hemianopia regain some of their lost visual field.

  Recruiting Georgetown University · Washington D.C., District of Columbia · NCT07105358

• Phase 2 pharmacodynamic test of sitagliptin for progressive grade 4 glioma

  This trial will try sitagliptin in adults with progressive grade 4 glioma to see if it lowers immune-suppressing MDSCs and boosts anti-tumor immune activity before surgery.

  Recruiting Phase 2 Case Comprehensive Cancer Center · Cleveland, Ohio · NCT07003542

• Home-based self-management and cognitive training for brain tumor survivors

  This trial will try a home-based cognitive coaching program to see if it improves thinking and quality of life for adults who survived non-glioblastoma brain tumors, with optional caregiver participation.

  Recruiting Dartmouth-Hitchcock Medical Center · Lebanon, New Hampshire · NCT06930846

• Testing TNG456 and Abemaciclib in Patients with Solid Tumors Lacking MTAP

  This study is testing a new drug called TNG456, alone and with another drug called abemaciclib, to see if it helps people with advanced solid tumors that have lost a specific gene called MTAP.

  Recruiting at 15 sites Phase 1/2 Tango Therapeutics, Inc. · Scottsdale, Arizona and 14 other locations · NCT06810544

• Evaluating sotorasib for treating brain tumors

  This study tests if a drug called sotorasib can help adults with certain types of brain tumors before they have surgery or a biopsy.

  Recruiting at 7 sites Phase 1 Memorial Sloan Kettering Cancer Center · Basking Ridge, New Jersey and 6 other locations · NCT06807619

• Using brodalumab to treat immune-related side effects from cancer therapy

  This study is testing if brodalumab can help cancer patients who are having immune-related side effects from their immunotherapy treatment feel better.

  Recruiting Phase 1 Columbia University · New York, New York · NCT06673329

• Combining TIL Therapy and Pembrolizumab for Advanced Brain Cancer

  This study is testing a new treatment that combines a type of immune therapy using patients' own tumor cells with Pembrolizumab to see if it helps people with advanced brain cancer feel better and live longer.

  Recruiting Phase 1/2 Essen Biotech · Beijing, Beijing Municipality · NCT06640582

• Testing Troriluzole for recurrent glioblastoma treatment

  This study is testing if Troriluzole can help people with recurrent glioblastoma feel better when given before and after surgery compared to just after surgery.

  Recruiting at 3 sites Early Phase 1 Dana-Farber Cancer Institute · Boston, Massachusetts and 2 other locations · NCT06552260

• Non-invasive methods for diagnosing and monitoring brain tumors

  This study is testing new blood and urine tests to see if they can help doctors better diagnose and monitor brain tumors in patients with glioblastoma.

  Recruiting The Institute of Molecular and Translational Medicine, Czech Republic · Olomouc · NCT06501521

• Evaluating Bevacizumab with Focused Ultrasound for Recurrent Glioblastoma

  This study is testing if adding focused ultrasound to the standard treatment of Bevacizumab can help people with recurrent glioblastoma feel better and live longer.

  Recruiting at 2 sites Phase 3 NaviFUS Corporation · Taipei and 1 other locations · NCT06496971

• Investigating brain tumors and their evolution

  This study looks at brain tumors in patients of all ages to see how their locations and structures relate to the evolution of the brain and skull, using imaging data from thousands of past cases.

  Recruiting Tata Memorial Centre · Mumbai, Maharashtra · NCT06381531

• Assessing postoperative recovery and adverse events in neurosurgery using a smartphone app

  This study is testing a smartphone app to see how well it can track recovery and any problems after brain surgery for patients.

  Recruiting Cantonal Hospital of St. Gallen · Sankt Gallen, St.Gallen · NCT06352710

• Genetic and molecular analysis of brain lesions

  This study is trying to better understand brain tumors and lesions by looking at their genetics and biology in patients who have had surgery, to help improve diagnosis and find new treatments.

  Recruiting at 3 sites Assistance Publique - Hôpitaux de Paris · Paris and 2 other locations · NCT06314607

• Using tranexamic acid to reduce bleeding during brain tumor surgery

  This study is testing if giving tranexamic acid during brain tumor surgery can help reduce bleeding and improve safety for patients.

  Recruiting Phase 3 Nova Scotia Health Authority · Halifax, Nova Scotia · NCT06229483

• Using MRI to Differentiate Between Brain Tumors and Radiation Effects

  This study is testing a new MRI technique to see if it can help tell the difference between brain tumors and radiation damage in people who have had radiation therapy.

  Recruiting at 2 sites Case Comprehensive Cancer Center · Cleveland, Ohio and 1 other locations · NCT06101069

• Real-time imaging during brain tumor surgery

  This study tests a new handheld imaging tool during brain tumor surgery to see if it helps doctors better tell the difference between healthy and tumor tissue in patients.

  Recruiting Northwell Health · Manhasset, New York · NCT06087393

• Using lithium to prevent cognitive decline after brain radiotherapy in children

  This study is testing if taking lithium can help prevent memory and thinking problems in children who have survived brain tumors and received radiation therapy.

  Recruiting Phase 2 Region Stockholm · Solna, Stockholm County and 1 other locations · NCT06051240

• Understanding brain function in epilepsy and brain tumor patients

  This study is trying to see how brain function differs between healthy people and those with epilepsy or brain tumors by using special imaging and brain mapping techniques.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT05989893

• Detecting microplastics in patients undergoing neurosurgery

  This study is trying to see if tiny pieces of plastic are found in the blood, brain fluid, and brain tissue of patients who are having brain surgery.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05968053

• Cognitive training using virtual reality for children with brain tumors undergoing radiotherapy

  This study is testing whether virtual reality brain training can help children with brain tumors feel better while they receive radiotherapy compared to using an iPad for the same training.

  Recruiting St. Jude Children's Research Hospital · Memphis, Tennessee · NCT05947045

• Using advanced imaging to improve brain tumor surgery

  This study is testing a new imaging technique during brain tumor surgery to see if it helps doctors better understand the tumor type and grade, which could lead to better treatment results for patients.

  Recruiting National Taiwan University Hospital · Taipei · NCT05943262

• Using advanced microscopy to study brain tissue and improve treatment for brain diseases

  This study is testing new ways to use brain tissue samples to improve treatments for brain diseases like tumors and help doctors plan better surgeries.

  Recruiting National Taiwan University Hospital · Taipei · NCT05921786

• Creating immune organoids to study pediatric cancers

  This study is trying to create mini immune systems from kids' tissues to see how they respond to different types of pediatric cancers.

  Recruiting at 2 sites Gustave Roussy, Cancer Campus, Grand Paris · Villejuif and 1 other locations · NCT05890781

• HOPE: Clinical, Pathology, and Imaging Project for Brain Tumors

  This project collects clinical records, MRI scans, and pathology data from people with glioma and other primary brain tumors to build large databases for improving diagnosis and care.

  Recruiting Beijing Tiantan Hospital · Beijing, Beijing Municipality · NCT05859659

• Remote neuropsychological assessments for patients with neurological disorders

  This study is testing a new online way to check brain function in patients with neurological disorders who have trouble getting to appointments.

  Recruiting Umeå University · Umeå · NCT05819008

• How focused ultrasound opening the blood–brain barrier changes the tumor surroundings

  This will try focused ultrasound before surgery in people with large gliomas to see if opening the blood–brain barrier changes the tumor's surrounding fluid and drug levels.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT05733312

• Impact of Radiotherapy on Neurocognition in Brain Tumor Patients

  This study is testing how radiotherapy affects thinking and memory in adults with brain tumors over time to see if certain treatments lead to cognitive decline.

  Recruiting at 3 sites Universitaire Ziekenhuizen KU Leuven · Ghent and 2 other locations · NCT05727605

• Gene therapy combined with radiotherapy for brain tumors

  This study is testing a new gene therapy combined with targeted radiation to see if it can safely help people with recurrent high-grade brain tumors.

  Recruiting Phase 1 Henry Ford Health System · Detroit, Michigan · NCT05686798

• Minimizing radiation impact on cognitive function in children with brain tumors

  This study is testing if a special way of planning radiation treatment can help protect the thinking skills of children with brain tumors while they receive their therapy.

  Recruiting at 2 sites Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Washington D.C., District of Columbia and 1 other locations · NCT05658731

• Testing zotiraciclib for recurrent brain tumors with specific gene mutations

  This study is testing a new drug called zotiraciclib to see if it can help people aged 15 and older with recurring brain tumors that have certain gene mutations.

  Recruiting at 2 sites Phase 1/2 National Institutes of Health Clinical Center (CC) · Jacksonville, Florida and 1 other locations · NCT05588141

• Collection of biological samples from brain tumor patients

  This study is collecting blood and spinal fluid samples from adults with brain tumors to help researchers learn more about the condition and improve treatments in the future.

  Recruiting Hospices Civils de Lyon · Bron, Rhône · NCT05571579

• Imaging tumors using a new dual-target agent

  This study is testing a new imaging agent to see if it can help doctors get a clearer picture of tumors in patients with breast, brain, and prostate cancers compared to standard imaging methods.

  Recruiting Early Phase 1 Peking Union Medical College Hospital · Beijing · NCT05549024

• Biofeedback training for improving vision in patients with hemianopia

  This study tests if biofeedback training can help people with vision loss from brain injuries learn to see better by improving how they move their eyes and focus on things.

  Recruiting University Health Network, Toronto · Toronto, Ontario · NCT05397873

• Investigating nutrition's impact on childhood cancer outcomes

  This study is trying to see how nutrition affects the health and recovery of children with leukemia and brain tumors in Southern Europe.

  Recruiting Columbia University · New York, New York · NCT05375617

• Mapping brain networks and blood flow for brain tumor surgery

  This study is testing a new brain imaging software to see if it can help plan safer brain tumor surgeries by mapping important brain networks better than traditional methods.

  Recruiting M.D. Anderson Cancer Center · Houston, Texas · NCT05342454

• Using light exposure to help pediatric brain tumor survivors with fatigue and cognitive issues

  This study is testing if bright light exposure can help children and teens who survived brain tumors feel less tired and think better.

  Recruiting Baylor College of Medicine · Houston, Texas · NCT05340881

• Opening the blood-brain barrier for treating brain metastases from lung cancer

  This study is testing if using focused ultrasound to open the blood-brain barrier can improve treatment for patients with brain metastases from lung cancer who are already receiving standard therapy.

  Recruiting at 9 sites Phase 3 InSightec · Phoenix, Arizona and 15 other locations · NCT05317858

• Measuring brain stimulation effects on hand strength in brain tumor patients

  This study tests if brain stimulation during surgery can improve hand strength and function in patients with brain tumors affecting the part of the brain that controls movement.

  Recruiting Medical College of Wisconsin · Milwaukee, Wisconsin · NCT05023434

• Using nanoparticles to enhance radiation treatment for brain metastases

  This study is testing if adding special nanoparticles to radiation therapy can help people with brain metastases get better results than radiation alone.

  Recruiting at 2 sites Phase 2 Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04899908

• Engineered TILs and CAR-TILs for treating advanced solid tumors

  This study is testing a new way to treat advanced solid tumors by using specially modified immune cells from patients to see if they can better fight the cancer.

  Recruiting Phase 1 Second Affiliated Hospital of Guangzhou Medical University · Guangzhou · NCT04842812

• Optimizing PET Imaging with 18F-DOPA for Various Conditions

  This study is testing if a special imaging technique using 18F-DOPA can help doctors see and understand conditions like congenital hyperinsulinism, neuroblastoma, neuroendocrine tumors, Parkinson's disease, and Lewy body dementia better in both kids and adults.

  Recruiting Phase 3 University of Alberta · Edmonton, Alberta · NCT04706910

• Using laser therapy and radiation to treat newly diagnosed gliomas

  This study is testing a new treatment that combines laser therapy and radiation to see if it helps people with newly diagnosed brain tumors called gliomas.

  Recruiting at 5 sites University of Maryland, Baltimore · Baltimore, Maryland and 4 other locations · NCT04699773

• Placement of Ommaya Reservoir for Brain Tumor Biomarker Access

  This study is testing if placing a small device called an Ommaya Reservoir during brain tumor surgery can help doctors easily collect fluid samples to better understand the tumor and improve treatment for patients.

  Recruiting Mayo Clinic · Rochester, Minnesota · NCT04692337

• Registry of patients with brain tumors treated with GammaTiles

  This study is testing how well GammaTiles treatment works for people with brain tumors after surgery, looking at their health and quality of life over five years.

  Recruiting at 49 sites GT Medical Technologies, Inc. · Phoenix, Arizona and 53 other locations · NCT04427384

• Identifying metabolic and immune biomarkers in neurological disorders

  This study is trying to see if measuring mitochondrial function can help identify children with neurological disorders like autism and epilepsy.

  Recruiting at 2 sites Southwest Autism Research & Resource Center · Phoenix, Arizona and 1 other locations · NCT04322734

• Metabolic analysis of brain tumors using advanced MRI techniques

  This study is testing advanced MRI techniques to see if they can help identify specific changes in brain tumors that could improve treatment and survival for patients with gliomas.

  Recruiting Insel Gruppe AG, University Hospital Bern · Bern · NCT04233788

• Panitumumab‑IRDye800 imaging to help surgeons find pediatric brain tumor tissue during neurosurgery

  This will test whether a fluorescent drug called panitumumab‑IRDye800 helps surgeons see tumor tissue and tiny residual disease in children and young adults having brain tumor surgery.

  Recruiting Phase 1/2 Stanford University · Stanford, California · NCT04085887

• Evaluating the impact of MR-guided radiation therapy on cancer treatment outcomes

  This study is testing how using a special type of radiation therapy with real-time imaging can improve treatment results and quality of life for adults with cancer.

  Recruiting at 14 sites UMC Utrecht · Pittsburgh, Pennsylvania and 17 other locations · NCT04075305

• Using MRI to distinguish between tumor recurrence and radiation effects in brain metastases

  This study is testing if new MRI techniques can help tell the difference between a returning brain tumor and changes caused by radiation in patients with brain metastases.

  Recruiting at 2 sites Brigham and Women's Hospital · Boston, Massachusetts and 1 other locations · NCT04033497

• Comparing awake craniotomy and general anesthesia for glioblastoma surgery

  This study is testing whether having brain surgery while awake is safer and more effective than having it under general anesthesia for people with glioblastoma in important areas of the brain.

  Recruiting at 5 sites Erasmus Medical Center · Ghent and 4 other locations · NCT03861299

• Non-invasive imaging to characterize gliomas

  This study is testing a new MRI method to see if it can help understand gliomas better by measuring certain substances in the tumor without needing any invasive procedures.

  Recruiting University of Miami · Miami, Florida · NCT03684109

• Analyzing MMP2 and MMP9 in Patients with Newly Diagnosed Glioblastoma

  This study is testing how levels of certain proteins in the blood relate to brain scans and tumor samples in people who have just been diagnosed with glioblastoma, to see how these levels change during treatment.

  Recruiting Assistance Publique Hopitaux De Marseille · Marseille · NCT03526822

• Proton Radiation for Treating Benign or Indolent Brain Tumors

  This study is testing whether Proton Radiation therapy can effectively treat adults with benign or slow-growing brain tumors and improve their quality of life.

  Recruiting Massachusetts General Hospital · Boston, Massachusetts · NCT03286335

• Combining capecitabine and temozolomide for newly diagnosed glioblastoma

  This study is testing if combining two cancer drugs, capecitabine and temozolomide, can help people with newly diagnosed glioblastoma live longer and feel better compared to using temozolomide alone.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT03213002

• Treatment of advanced solid tumors with APL-101 for specific genetic mutations

  This study is testing a new oral medication called APL-101 to see if it helps people with advanced lung cancer and other solid tumors that have certain genetic changes, especially those who haven't had success with standard treatments.

  Recruiting at 32 sites Phase 2 Apollomics Inc. · Los Angeles, California and 34 other locations · NCT03175224

• Letrozole treatment for recurrent brain tumors

  This study is testing if letrozole, when used with another drug, can safely help people with recurrent high-grade brain tumors.

  Recruiting Early Phase 1 University of Cincinnati · Cincinnati, Ohio · NCT03122197

• Treatment of newly diagnosed glioblastoma using targeted drug infusion

  This study is testing a new way to deliver a targeted drug directly to the brain tumor in people with newly diagnosed glioblastoma to see if it can improve their treatment outcomes.

  Recruiting Phase 1/2 Northwell Health · New York, New York · NCT02861898

• Targeting brain tumors with a specific drug infusion and re-irradiation

  This study is testing a new way to deliver a drug directly to brain tumors in patients with certain aggressive types of glioblastoma to see if it can improve treatment results.

  Recruiting Phase 2 Northwell Health · New York, New York · NCT02800486

NIH-funded research (newest 40 of 70)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Multi-center pediatric brain and spinal cord tumor treatment network

  Testing early-phase experimental treatments for children and young adults with brain and spinal cord tumors.

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11466965

• Safer T cell engagers for pediatric and adult brain tumors

  A potential new treatment using T cell engaging proteins to help fight brain tumors in both children and adults.

  NIH research Seattle Children's Hospital · Seattle, United States · NIH-11448639

• Non-invasive MR‑guided brain hyperthermia to boost brain cancer treatment

  A new MR‑compatible device heats brain tumors non‑invasively to help radiation, chemotherapy, and immunotherapy work better for brain cancer.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11448450

• Advanced brain imaging after proton therapy in kids with brain tumors

  This project looks at how advanced 7T MRI imaging can show long-term blood vessel and brain changes in children who have had proton radiotherapy for brain tumors.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11447207

• Rapid CEST MRI for Brain Tumor Imaging at 3T

  A high-tech MRI method is being developed to better distinguish brain tumors from treatment effects in patients using faster, more accurate scans.

  NIH research Emory University · Atlanta, United States · NIH-11432587

• AI-powered tool to diagnose and predict muscle disease in child brain-tumor survivors

  A pediatric brain-tumor survivor-focused project will use AI on routine imaging to identify muscle loss and forecast related health problems.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11426745

• Real-time brain tumor surgery guidance with resting-state brain maps during operation

  A real-time brain mapping tool using resting-state MRI is being developed to help surgeons guide tumor removal while the patient is in surgery.

  NIH research Neurinsight, LLC · Albuquerque, United States · NIH-11418910

• Imaging and Genomic Signs of Brain Tumors to Help Manage Care

  This project studies brain tumors in adults to find imaging and DNA clues that reflect tumor differences and how they change, with the goal of guiding better treatment decisions for glioblastoma and meningioma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11413758

• Proton versus X‑ray radiation: effects on thinking, symptoms, and daily function in children with brain tumors

  This project looks at how proton beam and conventional X‑ray radiation affect symptoms, thinking skills, and everyday functioning in children treated for brain tumors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11403684

• Proton vs. x-ray brain radiation: effects on thinking, symptoms, and daily life in children with brain tumors

  This project compares proton and traditional x‑ray brain radiation in children with brain tumors to find which approach better protects thinking skills, lowers symptom burden, and supports everyday functioning.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11403681

• Proton versus x‑ray radiation: thinking, symptoms, and daily function after childhood brain tumor treatment

  This project compares whether proton radiation or standard x‑ray radiation leads to fewer symptoms, better thinking skills, and easier daily life for children treated for brain tumors.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11403680

• Brain tumor SPORE grant supporting biomarker and immunotherapy advances

  A UCSF team is working with brain cancer patients to develop new blood and imaging markers and a novel immunotherapy to improve care.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11399828

• Understanding brain tumor metabolism with advanced carbon tracing

  This research looks at how brain tumor cells use nutrients like acetate and ketone bodies for energy, to help improve therapies for patients with gliomas and brain metastases.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11398098

• Pediatric brain tumor treatment with ultra-fast radiation therapy

  A new approach uses ultra-high dose-rate radiation (FLASH) to treat childhood brain tumors in mouse models, aiming to reduce normal brain damage while keeping tumor control.

  NIH research University of California-Irvine · Irvine, United States · NIH-11397562

• Computational imaging and molecular data modeling to track brain tumor recurrence

  A computer-based approach uses AI and data from brain scans and molecular tests to help detect when glioblastoma may come back or change after treatment, with the goal of guiding better care.

  NIH research Old Dominion University · Norfolk, United States · NIH-11385904

• Sialylation and brain tumor cell growth in glioblastoma

  This research asks how a sugar modification on proteins (sialylation) affects brain tumor cells in adults, especially glioblastoma.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11384447

• Using tiny implant devices to test many drugs in brain tumor patients

  A clinical study will place small implantable devices into brain tumors during surgery to test how 20 different treatments work in 32 glioma patients, guiding future personalized therapy.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11380803

• Overcoming brain-tumor treatment resistance with nanosized therapies in dogs

  Aimed at helping dogs with high-grade brain tumors by creating tiny, smart therapies that can get into tumors and work around resistance.

  NIH research University of California at Davis · Davis, United States · NIH-11369868

• Targeting immunosuppressive neutrophils to boost brain tumor therapies

  This grant aims to uncover how a special group of neutrophils helps brain tumors like glioblastoma resist treatment and to identify ways to block those cells to improve therapies.

  NIH research Wistar Institute · Philadelphia, United States · NIH-11368232

• Screening for protein interaction inhibitors of the ERKS axis to treat brain tumors

  Aims to find compounds that block a protein network called ERKS to slow or stop growth of malignant brain tumors in adults.

  NIH research Beckman Research Institute/city of Hope · Duarte, United States · NIH-11366177

• FLASH-CAR-T radioimmunotherapy for pediatric brain tumors

  A pediatric brain tumor research grant is exploring a new therapy that combines CAR-T cells with FLASH radiotherapy to help kids fight brain tumors.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11342264

• Focused ultrasound blood test to find brain tumor DNA

  This project uses focused ultrasound to gently release tumor DNA into the bloodstream so adults with brain tumors can get a less invasive molecular blood test.

  NIH research Washington University · Saint Louis, United States · NIH-11324241

• How the ABAT enzyme helps medulloblastoma spread in children

  This project looks at whether the enzyme ABAT helps medulloblastoma tumors in children survive and spread through the brain and spinal fluid.

  NIH research University of Southern California · Los Angeles, UNITED STATES · NIH-11310192

• Deuterated glucose imaging to see how brain tumors use sugar

  This work uses a safe, nonradioactive form of glucose and special MRI scans to show how brain tumors process sugar in people with brain cancer.

  NIH research Yale University · New Haven, United States · NIH-11307155

• Vascular signals that shape immune cells in brain tumors

  A study at UPenn will explore how blood vessels influence macrophages in glioblastoma to help develop better brain tumor immunotherapies for adults.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11278699

• How the brain represents objects and actions before and after brain tumor surgery

  Researchers compare how people's brains represent everyday objects and actions before and after brain tumor surgery using MRI scans and lesion mapping.

  NIH research Carnegie-Mellon University · Pittsburgh, United States · NIH-11251807

• Better MRI and genetic tests to understand and track adult brain tumors (glioblastoma and meningioma)

  This project uses advanced imaging and genetic information to find markers that help doctors treat adults with glioblastoma and meningioma.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11192762

• Using brain imaging to forecast glioblastoma growth and treatment response

  This project will use advanced MRI scans plus computer models to predict how a glioblastoma tumor may grow and respond to standard treatments for people with this diagnosis.

  NIH research University of Tx Md Anderson Can Ctr · Houston, United States · NIH-11190862

• Better treatments for glioblastoma

  Researchers are developing ways to make radiation and chemotherapy work better for people with glioblastoma.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11189635

• NeuroVu — a tiny remote microscope to watch how seizures affect brain tumors

  This project builds a small cloud-connected microscope to monitor how seizures and brain tumors interact, with the goal of helping people who have tumor-related epilepsy.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11181552

• Brain tumor treatment and biomarker program

  This program is creating blood tests, imaging markers, and a new immunotherapy to help people with glioma (a type of brain tumor).

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11178403

• Proton versus x‑ray brain radiation: effects on thinking, symptoms, and daily life in children

  Compares proton beam and conventional x‑ray brain radiation in children with brain tumors to find which approach leads to fewer side effects, better thinking skills, and improved daily functioning.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11177869

• Steerable robotic laser treatment for brain tumors

  This project is building a steerable robotic laser to better destroy glioblastoma and other brain tumors with minimally invasive probe placements.

  NIH research University of California Riverside · Riverside, United States · NIH-11172622

• Measuring how brain tumors use nutrients with advanced 13C tracers

  Researchers will give safe 13C-labeled nutrients and use special scans and tissue analysis to see which fuels gliomas and brain metastases burn in people with brain tumors.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11169989

• Tiny implantable devices to test many drugs in brain tumors

  Doctors will use tiny implantable devices during tumor surgery to see how an individual’s brain tumor reacts to many different drugs.

  NIH research Brigham and Women's Hospital · Boston, United States · NIH-11144443

• How a sugar-coating enzyme helps aggressive brain tumor cells survive and adapt

  Researchers are looking at whether the enzyme ST6Gal1 — which adds a sugar called sialic acid to proteins — helps aggressive glioblastoma cells stay stem-like and change their metabolism, which could matter for adults with glioblastoma.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11144280

• Ultra-fast (FLASH) radiation to protect children’s brains during medulloblastoma treatment

  This project sees if delivering radiation in an ultra-fast burst called FLASH can treat medulloblastoma in children while causing fewer long-term problems with thinking and brain blood vessels.

  NIH research University of California-Irvine · Irvine, United States · NIH-11143123

• Real-time brain mapping to guide tumor surgery

  This project builds automated real-time resting-state fMRI tools to help surgeons find and protect important brain networks during tumor operations.

  NIH research Neurinsight, LLC · Albuquerque, United States · NIH-11142186

• New Nanotherapies for Brain Tumors

  This research explores tiny new treatments called nanotherapeutics to help patients with aggressive brain tumors overcome resistance to current therapies.

  NIH research University of California at Davis · Davis, United States · NIH-11124143

• Improving brain function for children treated with radiation for brain tumors

  This research aims to find new ways to protect and repair the brain from damage caused by radiation therapy in children who had brain tumors.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11112415

Related topics

Quick answers

How many Brain Tumor clinical trials are recruiting right now?

70, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 22 countries. The most sites are in United States (43 trials), Canada (6 trials), France (5 trials), China (5 trials), Belgium (4 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 7, Phase 1/2: 6, Phase 1: 5, Phase 3: 4. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

Describe your situation →