Exploring neuroplasticity through proprioceptive rehabilitation with muscle vibrations

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study investigates the effects of muscle tendon vibrations on neuroplasticity in patients recovering from stroke or traumatic brain injury. It involves a randomized control design with 28 patients receiving active vibrations and 28 receiving sham stimulation over a 5-week treatment period. Participants will undergo various electrophysiological assessments, including EMG, EEG, and MRI, to evaluate changes in cerebrospinal circuitry and motor recovery. The study aims to enhance understanding of how proprioceptive rehabilitation can promote neuroplastic changes during the subacute phase of recovery.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* hemiparesis at least transient in lower limb following an acquired brain injury (stroke or traumatic brain injury)
* French spoken
* Affiliated to a French social insurance
* No previous traumatic, vascular or neurodegenerative injuries
* Having presented during the acute phase or presenting a motor deficit of one of the lower limbs
* Presenting an absence of autonomy of walking at the entrance of the rehabilitation department
* In the sub-acute phase, i.e. from 15 days to 6 months after the accident
* Presenting moderate cognitive disorders allowing them to understand instructions and give their consent

Exclusion Criteria:

* strong cognitive disorders
* maintenance of justice, tutelage, legal guardianship
* Pregnancy and breastfeeding
* Outpatients who do not have weekly follow-up in the rehabilitation department

Where it's running

• Pitié-Salpêtrière Hospital
  Paris, France Recruiting

Study contacts

• Principal investigator: Eleonore Bayen, MD, PhD — Sorbonne University - AP-HP (Pitié-Salpêtrière Hospital)
• Study coordinator: Veronique Marchand-Pauvert, PhD
• Email: veronique.marchand-pauvert@inserm.fr
• Phone: +33142161120

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.