Lipid imaging in brain injury to map damaged cells and lipids
Official title: Lipid Imaging in Traumatic Brain Injury by High Resolution GCIB-secondary Ion Mass Spectrometry
Funded at Columbia University Health Sciences · NIH-11396254 · Data updated 2026-11-12
A study looking at brain injury to map where lipids change and which cells are affected, using advanced imaging to guide future therapies.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | July 1, 2012 |
| Project end | July 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $602,698 |
| NIH project number | 5R01NS076511-14 |
| Project ID | NIH-11396254 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with traumatic brain injury or their tissue samples may benefit from advances arising from this research in the future.
✕Less likely to help
People without brain injury or without access to advanced imaging-informed therapies may not directly benefit.
What this research studies
This project uses high-resolution imaging to map lipid changes in brain tissue after traumatic injury. It couples a cutting-edge imaging technique with antibody tagging to see which cells undergo lipid peroxidation and ferroptosis. The goal is to understand cell-type differences and why certain lipids drive damage, so future treatments can target these processes. By generating detailed maps of lipid changes at the subcellular level, the research aims to inform new strategies to protect brain cells after injury.
Why it matters
Potential benefit: If successful, the work could lead to targeted therapies that limit brain cell death after injury and improve recovery.
How similar studies have gone: Similar advanced lipid-imaging approaches have shown promise in identifying lipid changes in diseased tissues, supporting the potential of this method.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Bayir, Hülya — Columbia University Health Sciences
- Study coordinator: Bayir, Hülya
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.