Condition

Spinal Cord Injury clinical trials and research

• 98Clinical trials
• 232NIH research projects
• 7New in 30 days
• 24Countries

Newest Spinal Cord Injury clinical trials

All recruiting trials (98)

• Implanted Brain-Computer Interface to Help People with Severe Arm Impairment

  We’re testing the N1 System, a fully implanted brain interface in the motor cortex with a robot, to see if it can help adults with spinal cord injury, ALS, or chronic stroke use a computer or keyboard more easily.

  Recruiting Neuralink Corp · Miami, Florida · NCT07929792

• tSCS with rehabilitation for improving movement after spinal cord injury

  This study tests whether adding rehabilitation training to transcutaneous spinal cord stimulation helps paraplegic patients regain voluntary movement after spinal cord injury.

  Recruiting Beijing Tsinghua Chang Gung Hospital · Beijing · NCT07907952

• Informational Needs of Caregivers of Patients in Neuro Rehab: Validating the QBI-R/V

  This study tests a caregiver questionnaire (QBI-R and QBI-V) to see how well it measures caregivers’ informational needs during neuromotor rehabilitation.

  Recruiting at 13 sites Istituti Clinici Scientifici Maugeri SpA · Sciacca, Agrigento and 12 other locations · NCT07903298

• Biomechanical and Perceived Effort in Manual Wheelchair Propulsion

  This study tests whether combining objective shoulder loading data with how hard people feel they’re working can reveal how difficult manual wheelchair propulsion is for users with spinal cord injury.

  Recruiting Centre Médico-Chirurgical de Réadaptation des Massues Croix Rouge Française · Lyon · NCT07897214

• Shockwave therapy added to toxin injections to help spasticity after spinal cord injury

  Aims to see if focused shockwave therapy plus Botox injections reduce spasticity better than Botox alone in adults with spinal cord injury.

  Recruiting Phase 2 Kessler Foundation · West Orange, New Jersey · NCT07894991

• Vibratory Genital Nerve Stimulation to Help Female Sexual Function After Spinal Cord Injury

  This study tests whether a home-use vibration device can improve sexual function in cisgender women with spinal cord injury by increasing genital blood flow during arousal.

  Recruiting Hennepin Healthcare Research Institute · Minneapolis, Minnesota · NCT07870642

• How VR Can Make a Virtual Body Feel Real

  This study tests different immersive virtual reality techniques to see which best makes a person feel the virtual body as their own, including in people with spinal cord injury or stroke.

  Recruiting IRCCS Eugenio Medea · Bosisio Parini, Lecco · NCT07870044

• Patterns of Rehabilitation After Spinal Cord Injury

  This study looks at how long people stay in the hospital and how long it takes them to return to daily life after a spinal cord injury while they continue rehabilitation.

  Recruiting Gaziler Physical Medicine and Rehabilitation Education and Research Hospital · Ankara, Çankaya · NCT07865338

• Robot-assisted intensive physiotherapy for spinal cord injury

  Researchers are testing whether robot-assisted physiotherapy added to a trunk-focused program helps improve trunk control, posture, and daily tasks in people with spinal cord injury.

  Recruiting Nuh Naci Yazgan University · Nevşehir · NCT07849062

• Time comparison of bowel programs in spinal cord injury

  This study tests which of three bowel-management tools (a suppository, a mini enema, or a transanal irrigation device) helps people with spinal cord injury complete their bowel program the quickest.

  Recruiting Casa Colina Hospital and Centers for Healthcare · Pomona, California · NCT07817199

• Paired Stimulation to Help Motor Recovery in Adults With and Without Spinal Cord Injury

  This study tests whether paired stimulation can boost how nerves control leg movement in adults with spinal cord injury and in healthy controls.

  Recruiting Phase 2 Shirley Ryan AbilityLab · Chicago, Illinois · NCT07814313

• Improving Movement After Paralysis with an Implanted Neural Stimulation Device

  We’re testing whether an implanted neural stimulation system can help people with paralysis from spinal cord injury, stroke, MS, or traumatic brain injury move more easily and perform daily activities.

  Recruiting Louis Stokes VA Medical Center · Cleveland, Ohio · NCT07738978

• Fully implanted wireless brain-computer interface to replace upper limbs in tetraplegia

  This study tests a fully implanted brain-computer interface to help people with tetraplegia from spinal cord injury regain hand and arm function.

  Recruiting NeuroXess Technology (shanghai) Co.,Ltd. · Shanghai, Shanghai Municipality · NCT07720882

• Transcutaneous Spinal Stimulation to Boost Exercise in Spinal Cord Injury

  Researchers are testing whether a skin-friendly spinal stimulation method can help people with spinal cord injury exercise more effectively.

  Recruiting University of Manitoba · Winnipeg, Manitoba · NCT07692191

• Rhythmic cues to help walking after spinal cord injury

  This pilot test will see if a wearable rhythm device (MedRhythms) can help adults with motor incomplete spinal cord injury walk more steadily and comfortably.

  Recruiting University of California, Davis · Sacramento, California · NCT07674927

• Brain-Computer Interface to Control Digital Devices for People with High Cervical Spinal Cord Injury

  This study tests a fully implantable brain-computer interface to let people with high cervical spinal cord injuries control digital devices at home.

  Recruiting UMC Utrecht · Utrecht, Utrecht · NCT07640711

• Fermented foods for bowel health in adults with spinal cord injury

  This study tests whether a diet rich in fermented foods improves bowel function and gut health in adults with chronic spinal cord injury.

  Recruiting Ohio State University · Columbus, Ohio · NCT07640152

• Galantamine treatment for metabolic syndrome in people with spinal cord injury

  This study tests whether galantamine can help reduce metabolic syndrome and inflammation in adults with chronic spinal cord injury.

  Recruiting at 2 sites Phase 2/3 Northwell Health · West Orange, New Jersey and 2 other locations · NCT07625332

• Implantable wireless brain–machine interface for spinal cord injury

  This study tests an implantable wireless brain–machine interface in adults with cervical spinal cord injury to see if it can safely and effectively enable brain-controlled movement.

  Recruiting Shanghai StairMed Technology Co., Ltd. · Shanghai, Shanghai Municipality · NCT07603752

• FES-Cycling With Blood Flow Restriction for SCI/D Patients

  This study tests safe and feasible use of functional electrical stimulation cycling with blood flow restriction in adults with spinal cord injury to see if it can help reduce cardiometabolic risk.

  Recruiting Phase 1 Toronto Rehabilitation Institute · Toronto, Ontario · NCT07588503

• Near-infrared monitoring of spinal cord oxygenation during aortic surgery

  This will try using skin-surface near-infrared sensors on the back to continuously track spinal cord oxygen levels in adults having major thoracic or thoracoabdominal aortic surgery.

  Recruiting Monaldi Hospital · Naples, Italy · NCT07541612

• Non-invasive spinal cord stimulation to improve blood pressure control after spinal cord injury

  We will test whether non-invasive spinal cord stimulation can help adults with chronic spinal cord injuries at or above T1 who have troublesome low or unstable blood pressure.

  Recruiting University of Louisville · Louisville, Kentucky and 1 other locations · NCT07504055

• Focused shockwave treatment for elbow and wrist spasticity after spinal cord injury

  This project will try focused extracorporeal shockwave therapy on the elbow and wrist to reduce spasticity in adults with chronic spinal cord injury.

  Recruiting Phase 1 Kessler Foundation · West Orange, New Jersey · NCT07501429

• Gait and Achilles Tendon Properties in Spastic Paresis

  This study tests how the Achilles tendon and calf muscle function during walking in people with spastic weakness after stroke or spinal cord injury, compared with healthy individuals.

  Recruiting Nantes University Hospital · Nantes · NCT07467382

• Noninvasive brain and nerve stimulation to improve hand grasp after cervical spinal cord injury

  This trial will test whether combining noninvasive brain stimulation (iTBS) and paired corticospinal-motoneuronal stimulation with hand exercises can improve grasping in people with chronic cervical spinal cord injury.

  Recruiting State University of New York at Buffalo · Buffalo, New York · NCT07433959

• Tibial nerve stimulation plus standing to improve pelvic floor and bladder function after spinal cord injury

  This trial will try combining tibial nerve stimulation with standing therapy in adults with chronic spinal cord injury to see if it improves pelvic floor reflexes, urinary symptoms, and quality of life.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT07429305

• How upper-limb assistive devices affect users' daily life

  This project will see if using a CE-marked upper-limb assistive device helps adults with stroke, spinal cord injury, or neuromuscular disorders improve independence, satisfaction, and social participation.

  Recruiting at 2 sites Association APPROCHE · Perpignan and 1 other locations · NCT07429188

• Measuring how assistive technologies and brain-computer interfaces help people use digital devices

  This project will test a Digital Assessment Interface to see if it can measure how well different assistive technologies and brain-computer interfaces help adults with spinal cord injury or ALS use computers, phones, and other digital systems.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT07407725

• Spatial StimelMD for upper-limb recovery after stroke or traumatic brain injury

  This trial will test whether adding the Spatial StimelMD device to standard rehabilitation helps adults with upper-limb weakness after stroke or traumatic brain injury improve arm movement.

  Recruiting Motion Informatics LTD · Haifa · NCT07404761

• Intranasal insulin for adults with spinal cord injury

  This trial will test whether a daily insulin nasal spray is safe for adults who had a spinal cord injury at least four months ago.

  Recruiting Phase 1 HealthPartners Institute · Saint Paul, Minnesota · NCT07384052

• Sacral and tibial nerve stimulation to improve bladder function after recent suprasacral spinal cord injury

  This trial will test whether noninvasive sacral or tibial nerve stimulation can prevent or reduce overactive bladder in adults within six months of a suprasacral spinal cord injury.

  Recruiting Ankara City Hospital Bilkent · Ankara, Çankaya · NCT07343583

• Combining non-invasive brain and spinal cord stimulation to improve arm and hand function

  This study tests whether pairing non-invasive brain stimulation (tDCS) with spinal cord stimulation (tSCS) during a cognitive-motor task can improve sensorimotor and cognitive-motor function in people with cervical spinal cord injury or stroke compared with each stimulation alone or sham.

  Recruiting at 2 sites Phase 2 Centre National de la Recherche Scientifique, France · Bordeaux and 1 other locations · NCT07334977

• Individualised cryoneurolysis for pain from spasticity in the arms and legs

  This will try freezing specific nerves (cryoneurolysis) or using botulinum toxin to see which reduces pain from spasticity in adults with stroke, spinal cord injury, brain injury, or multiple sclerosis.

  Recruiting Phase 4 Oxford University Hospitals NHS Trust · Oxford · NCT07303582

• Repetitive TMS to relieve neuropathic pain after spinal cord injury

  This trial will test whether rTMS aimed at the anterior cingulate cortex reduces chronic neuropathic pain in adults with spinal cord injury compared with motor cortex stimulation or a sham treatment.

  Recruiting at 2 sites Ankara Etlik City Hospital · Ankara, Yenimahalle and 1 other locations · NCT07293780

• Mobile health app (iMHere 2.0) for veterans with spinal cord injury and their family caregivers

  Try an adapted iMHere 2.0 mobile app to help veterans with spinal cord injury and their family caregivers manage self-care and psychosocial needs.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07269977

• Psilocybin for depression after spinal cord injury

  This trial will test whether three doses of psilocybin (5 mg, 10 mg, and 25 mg) are safe and tolerable for adults with chronic spinal cord injury who have major depression.

  Recruiting Phase 1/2 James J. Peters Veterans Affairs Medical Center · The Bronx, New York · NCT07251491

• Shoulder Health After Rehab: Home-Based Strength Training for wheelchair users

  This study tests a home-based shoulder strength training program for manual wheelchair users who recently left rehabilitation to see if starting the training at 3 months versus 12 months after discharge affects shoulder health.

  Recruiting Swiss Paraplegic Research, Nottwil · Nottwil, Canton of Lucerne · NCT07245706

• ARC-IM therapy to help restore walking after spinal cord injury

  This study will try ARC-IM Therapy (epidural electrical stimulation) in adults with subacute or chronic traumatic spinal cord injury to see if it helps improve walking and other ambulatory functions.

  Recruiting Ecole Polytechnique Fédérale de Lausanne · Nottwil, Canton of Lucerne and 1 other locations · NCT07234903

• Hands-free self-balancing personal exoskeleton for people with spinal cord injury

  Researchers will test a hands-free, self-balancing exoskeleton to see if it can safely help adults with spinal cord injury stand, walk, and move in daily life.

  Recruiting Wandercraft · New York, New York · NCT07222033

• Vibrant capsule treatment for neurogenic bowel in spinal cord injury

  This trial will test whether taking the Vibrant capsule is safe and helps bowel control in people with chronic spinal cord injury who have upper motor neuron neurogenic bowel.

  Recruiting The University of Texas Health Science Center, Houston · Houston, Texas · NCT07213986

• Brain stimulation training to strengthen wrist extension after cervical spinal cord injury

  This study will test whether MEP up-conditioning using transcranial magnetic stimulation can help people with incomplete cervical spinal cord injury improve wrist extension.

  Recruiting Medical University of South Carolina · Charleston, South Carolina · NCT07179822

• Neuro20 electrical stimulation suit to improve autonomic control, muscle performance, and walking after amputation or neurologic injury

  This will test whether wearing the Neuro20 electrical stimulation suit helps people at least one week after an amputation or neurologic injury (stroke, spinal cord injury, or brain injury) improve autonomic function, muscle strength, and walking.

  Recruiting Brooks Rehabilitation · Jacksonville, Florida and 1 other locations · NCT07164846

• Robotically implanted Neuralink N1 brain-computer interface to control external devices

  This study will test whether a robotically implanted Neuralink N1 brain-computer interface can safely help people with high spinal cord injuries or ALS control computers and other external devices.

  Recruiting at 2 sites Neuralink Corp · London, Greater London and 1 other locations · NCT07127172

• Neuromuscular electrical stimulation to improve blood sugar control after spinal cord injury

  This trial will test whether neuromuscular electrical stimulation (NMES) can improve blood sugar control in adults with spinal cord injury compared with a sham condition and with people without injury.

  Recruiting University of Bath · Bath, United Kingdom · NCT07099911

• Targeting the plantaris tendon during surgery to correct ankle equinus in children

  This trial tests whether cutting the small plantaris tendon, together with standard calf-lengthening surgery, helps children aged 4–17 with ankle equinus walk and use their feet better.

  Recruiting University of Alberta · Edmonton, Alberta · NCT07090057

• Home-based exoskeleton training to help people with spinal cord injury walk

  This trial tests whether the ABLE Daily exoskeleton can safely help adults with spinal cord injury stand, walk, and navigate stairs at home and in the community.

  Recruiting ABLE Human Motion S.L. · Hengstdal, Ubbergen · NCT07062575

• Wearable exoskeleton-assisted walking for people with recent spinal cord injury in Spanish hospitals

  This trial will test whether a wearable powered lower-limb exoskeleton helps people with recent spinal cord injury walk better and lowers caregiver and healthcare costs compared with conventional therapy in Spain.

  Recruiting ABLE Human Motion S.L. · Toledo, Castille-La Mancha and 1 other locations · NCT07036107

• Tele-Exercise program to empower movement for people with spinal cord injury

  A randomized study tests whether a live tele-exercise program (TEEMS) improves physical activity participation and psychosocial factors more than a library of pre-recorded exercises for adults with spinal cord injury.

  Recruiting Drexel University · Philadelphia, Pennsylvania · NCT07022808

• Robotically implanted brain chip to help control external devices

  This tests a wireless, rechargeable brain implant (Neuralink N1) and a robot surgical system (R1) to help people with severe arm and hand paralysis control external devices.

  Recruiting Neuralink Corp · Abu Dhabi · NCT06992596

• Training to boost brain-to-spine signals for better wrist and hand control

  This trial will test whether 10 weeks of non-invasive brain stimulation with feedback can strengthen brain-to-spinal-cord signals and improve wrist and hand function in adults with chronic cervical spinal cord injury and weak wrist extension.

  Recruiting Early Phase 1 Medical University of South Carolina · Charleston, South Carolina · NCT06989905

• iPSC-derived motor neuron progenitor cell therapy for subacute spinal cord injury

  This trial will test whether XS228 (iPSC-derived motor neuron progenitor cells) is safe and tolerable for adults 18–65 with recent (14–60 day) cervical to lumbar traumatic spinal cord injuries classified AIS A–C.

  Recruiting Phase 1 XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd. · Guangzhou, Guangdong · NCT06976229

• Using brain-computer interface technology to improve walking in spinal cord injury patients

  This study is testing a new brain-computer interface system to see if it can help people with spinal cord injuries walk better and improve their quality of life.

  Recruiting Xuanwu Hospital, Beijing · Beijing, Beijing Municipality · NCT06939660

• First-in-human STUP-001 gene therapy to convert spinal cord support cells into neurons for chronic spinal cord injury

  This trial will test STUP-001, an AAV gene therapy that aims to convert astrocytes into neurons, in adults 19–60 with chronic AIS-A or AIS-B spinal cord injuries to see if it is safe and shows early signs of helping function.

  Recruiting Phase 1/2 Yonsei University · Seoul · NCT06922890

• Using music to reduce stress during botulinum toxin injections for spasticity

  This study tests if listening to music during botulinum toxin injections can help adults with spasticity feel less pain and anxiety.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT06920524

• Exploring the link between menstrual cycles and urinary incontinence in women with spinal cord injuries

  This study looks at how changes in hormones during the menstrual cycle might affect bladder control in women with spinal cord injuries to see if it can help improve treatment options.

  Recruiting Swiss Paraplegic Research, Nottwil · Nottwil · NCT06892080

• Comparing wheelchair treadmill exercises to conventional exercises for trunk balance in spinal cord injury patients

  This study is testing if using a wheelchair treadmill can help people with spinal cord injuries improve their trunk balance better than regular wheelchair exercises.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT06876285

• Probiotic and prebiotic supplements for digestive health after chronic spinal cord injury

  This trial will test whether taking a probiotic or a prebiotic can improve digestive symptoms, gut microbiome balance, inflammation, and transit time in adults with long-term spinal cord injury.

  Recruiting Swiss Paraplegic Research, Nottwil · Nottwil, Canton of Lucerne · NCT06870331

• Spine and brain stimulation to restore arm and hand movement after cervical spinal cord injury.

  This will try temporary cervical spinal cord electrical stimulation together with noninvasive brain stimulation to improve arm and hand movement in adults with chronic incomplete cervical spinal cord injury.

  Recruiting at 2 sites Columbia University · New York, New York and 1 other locations · NCT06867809

• Epidural electrical stimulation for bladder control after spinal cord injury

  This study will try epidural electrical stimulation to improve bladder control in adults with sub-acute or chronic spinal cord injury who have neurogenic urinary dysfunction and use intermittent catheterization.

  Recruiting Ecole Polytechnique Fédérale de Lausanne · Lausanne, Canton of Vaud · NCT06845904

• Device to deliver LCTOPC1 into the spinal cord for people with cervical or thoracic injuries

  This trial will test a new device that injects LCTOPC1 cells into the spinal cord of adults with recent or chronic cervical or thoracic spinal cord injuries to see if it can be given safely.

  Recruiting Phase 1 Lineage Cell Therapeutics, Inc. · Downey, California and 1 other locations · NCT06841770

• CBD for bladder control after spinal cord injury

  This test gives adults with recent supra‑sacral spinal cord injury purified CBD (Epidiolex) twice daily for 90 days to see if it reduces urinary incontinence and other bladder symptoms.

  Recruiting Phase 2 University of Wisconsin, Madison · Madison, Wisconsin · NCT06840899

• I-SCRIBBLE: Tracking blood biomarkers after spinal cord injury

  This project will test whether blood levels of NF-L and GFAP taken soon after a traumatic spinal cord injury can help predict whether someone will have motor-complete or motor-incomplete impairment at six months.

  Recruiting at 2 sites AO Foundation, AO Spine · Milwaukee, Wisconsin and 7 other locations · NCT06839300

• At-home electrical stimulation for bowel management in spinal cord injury

  This study is testing if using a special electrical device at home can help people with spinal cord injuries have fewer bowel accidents.

  Recruiting MetroHealth Medical Center · Cleveland, Ohio · NCT06836739

• Wireless brain implant for controlling devices

  This study is testing a new wireless brain implant that helps paralyzed and amputee patients control devices just by thinking, to see if it can improve their daily lives.

  Recruiting Shanghai StairMed Technology Co., Ltd. · Shanghai, Shanghai Municipality · NCT06829212

• Digital versus traditional ankle-foot orthoses for people with lower limb weakness

  We will try if ankle-foot braces made with 3D scanning and printing work as well as traditional plaster-cast braces for people with leg weakness or stiffness from conditions like stroke or cerebral palsy.

  Recruiting Holland Bloorview Kids Rehabilitation Hospital · Mississauga, Ontario and 1 other locations · NCT06828653

• Cryoneurolysis for shoulder pain and spasticity management

  This study tests if a new cold treatment for shoulder pain can help people with hemiplegia feel better and move better compared to the usual botulinum injections.

  Recruiting Centre National de Rééducation Fonctionnelle et de Réadaptation · Luxembourg · NCT06782464

• COSCINUS cohort and biocollection for spinal cord injury

  This project collects clinical information and blood, urine, and stool samples to see patterns and risk factors in people with spinal cord injury.

  Recruiting Nantes University Hospital · Nantes, Loire-Atlantique · NCT06734000

• Tendon-lengthening surgery versus botulinum toxin injections for hand and wrist spasticity

  This project tries to see if tendon-lengthening surgery helps adults with hand and wrist spasticity after stroke, spinal cord injury, or traumatic brain injury more than ongoing botulinum toxin injections.

  Recruiting Vastra Gotaland Region · Mölndal · NCT06733025

• Testing spinal cord stimulation and its effects on brain activity

  This study is testing if spinal cord stimulation can improve brain activity in people with spinal cord injuries to help them recover better.

  Recruiting at 2 sites Far Eastern Federal University · Vladivostok, Primorskiy (Maritime) Kray and 2 other locations · NCT06725836

• Pelvic floor muscle training for bladder, bowel, and sexual function in spinal cord injury patients

  This study is testing if a pelvic floor muscle training program can help people with spinal cord injuries improve their bladder, bowel, and sexual function.

  Recruiting University of British Columbia · Vancouver, British Columbia · NCT06705790

• Robotically implanted brain-computer interface for controlling devices

  This study is testing a new brain implant and robot to see if they can help people with severe movement limitations control devices more easily.

  Recruiting Neuralink Corp · Toronto, Ontario · NCT06700304

• Low-oxygen breathing to improve 24-hour blood pressure stability after cervical spinal cord injury

  This trial will try whether brief sessions of breathing lower-oxygen air can improve 24-hour blood pressure stability in adults with chronic cervical spinal cord injury.

  Recruiting at 2 sites Phase 1/2 University of British Columbia · Kelowna, British Columbia and 1 other locations · NCT06691165

• Peer health coaching with a web-based self-management program for people newly discharged after spinal cord injury

  This study will test whether a web-based self-management program with trained peer health coaches helps people within three years of a spinal cord injury manage their health after leaving inpatient rehabilitation.

  Recruiting at 2 sites University of Toronto · Milford, Connecticut and 1 other locations · NCT06677905

• Mindfulness training using virtual reality for veterans with spinal cord injuries

  This study is testing a virtual reality mindfulness program to see if it can help veterans with spinal cord injuries manage pain better and improve their quality of life.

  Recruiting VA Office of Research and Development · Houston, Texas · NCT06587607

• Preventing pressure injuries in veterans with spinal cord injuries

  This study is testing a new tool to help veterans with spinal cord injuries avoid pressure injuries by identifying their risks and needs better.

  Recruiting at 6 sites VA Office of Research and Development · Long Beach, California and 7 other locations · NCT06529094

• Cervical epidural stimulation to improve autonomic and voluntary function after spinal cord injury

  This trial will test an implanted cervical epidural stimulator to see if it improves autonomic control, trunk stability, and voluntary movement in adults with chronic motor-complete cervical spinal cord injuries.

  Recruiting Phase 1/2 University of Minnesota · Minneapolis, Minnesota · NCT06410001

• Remote training program for manual wheelchair skills

  This study tests whether a remote training program with peer coaching can help people improve their manual wheelchair skills and mobility.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT06295146

• Using epidural stimulation to improve rehabilitation outcomes for cervical spinal cord injuries

  This study is testing if a new treatment using epidural stimulation along with arm exercises can help people with cervical spinal cord injuries improve their arm function.

  Recruiting The Methodist Hospital Research Institute · Houston, Texas · NCT06225245

• Effects of testosterone on nerve function in men with spinal cord injury

  This study tests if a single dose of intranasal testosterone can help improve nerve function in men with spinal cord injuries who have low testosterone levels.

  Recruiting Early Phase 1 VA Office of Research and Development · The Bronx, New York · NCT06130449

• Wearable lower-limb exoskeleton to stretch legs and improve walking

  This research will test a portable wearable exoskeleton to help people with spasticity from spinal cord injury increase leg range of motion and improve walking.

  Recruiting VA Office of Research and Development · Syracuse, New York · NCT05926596

• Spinal cord stimulation plus robotic walking training for chronic spinal cord injury

  This project will test whether adding non-invasive spinal cord stimulation to robotic gait training helps people with chronic incomplete spinal cord injury walk and move better and improve quality of life.

  Recruiting National University Hospital, Singapore · Singapore, Singapore · NCT05921175

• Calcitonin treatment for neuropathic pain after spinal cord injury

  This study is testing if calcitonin can help reduce the pain that people experience after a spinal cord injury compared to a placebo.

  Recruiting Tanta University · Tanta, Gharbia Governorate · NCT05805683

• Non-invasive spinal cord stimulation to restore autonomic function after spinal cord injury

  This trial tests whether transcutaneous spinal cord stimulation can help adults with chronic spinal cord injury improve blood pressure control, bladder, bowel, or sexual problems.

  Recruiting at 2 sites University of British Columbia · Vancouver, British Columbia and 1 other locations · NCT05369520

• Using spinal cord stimulation to improve movement in people with tetraplegia

  This study is testing if a new type of electrical stimulation can help improve arm movement in people with spinal cord injuries.

  Recruiting at 2 sites VA Office of Research and Development · Chicago, Illinois and 1 other locations · NCT05157282

• Visual illusion therapy plus conventional exercises for improving upper limb function after incomplete spinal cord injury

  This trial tests whether adding visual illusion therapy to standard exercises helps people with incomplete spinal cord injury improve upper-limb movement.

  Recruiting University of Valencia · Valencia, Valencia · NCT05142943

• Using Exciflex bandages to treat chronic wounds in veterans

  This study is testing whether a new type of bandage can help veterans with chronic wounds heal better than the usual treatment.

  Recruiting VA Office of Research and Development · Cleveland, Ohio · NCT04887688

• Using electrical stimulation to improve movement in people with paralysis or weakness

  This study is testing if using electrical stimulation can help people with paralysis or weakness from spinal cord injuries or strokes improve their movement.

  Recruiting Early Phase 1 Northwell Health · Manhasset, New York · NCT04755699

• Combining testosterone therapy with walking training to improve health after spinal cord injury

  This study is testing if combining testosterone therapy with walking training can help men with spinal cord injuries who have low testosterone and trouble walking improve their health and mobility.

  Recruiting at 2 sites Phase 2 North Florida Foundation for Research and Education · Gainesville, Florida and 1 other locations · NCT04460872

• Combining exoskeleton-assisted walking with spinal stimulation for spinal cord injury recovery

  This study is testing if using a special walking robot along with nerve stimulation can help people with partial spinal cord injuries walk better.

  Recruiting Kessler Foundation · West Orange, New Jersey · NCT03096197

• Deep brain stimulation to improve walking in patients with incomplete spinal cord injury

  This study is testing if a new brain stimulation treatment can help people with incomplete spinal cord injuries walk better and improve their quality of life.

  Recruiting University of Zurich · Zurich · NCT03053791

• Improve dynamic lateral balance during walking after spinal cord injury

  This trial will test whether adding pelvis perturbation training with transcutaneous spinal direct current stimulation (tsDCS) helps adults with spinal cord injury improve dynamic balance and walking compared with sham stimulation or treadmill-only training.

  Recruiting Shirley Ryan AbilityLab · Chicago, Illinois · NCT02991248

• Treatment for sleep apnea in patients with cervical spinal cord injuries

  This study tests new ways to help people with cervical spinal cord injuries who have sleep apnea by looking at how low oxygen levels and extra oxygen can affect their breathing during sleep.

  Recruiting Phase 4 John D. Dingell VA Medical Center · Detroit, Michigan · NCT02922894

• Improving bladder function in spinal cord injury patients using neuromodulation

  This study is testing if new electrical and magnetic treatments can help people with spinal cord injuries improve their bladder control and function.

  Recruiting University of California, Los Angeles · Los Angeles, California · NCT02331979

• Using brain-machine interface technology to help individuals with severe paralysis control devices

  This study tests if people with severe paralysis can use a brain-machine interface to control devices just by thinking, helping them interact with the world despite their inability to move.

  Recruiting at 2 sites University of Pittsburgh · Chicago, Illinois and 1 other locations · NCT01894802

• Observational study on spinal cord injury recovery in Europe

  This study is trying to understand how people recover from spinal cord injuries by collecting information from patients in Europe who have recently experienced these injuries.

  Recruiting University of Zurich · Zurich · NCT01571531

• A device to improve sitting posture and balance for individuals with spinal cord injuries

  This study is testing a new device that helps people with spinal cord injuries sit better and improve their balance by using electrical stimulation to strengthen their muscles.

  Recruiting VA Office of Research and Development · Cleveland, Ohio · NCT01474148

• Program to improve male fertility after spinal cord injury

  This study is testing a program to help men with spinal cord injuries improve their fertility by looking at issues like erectile dysfunction and semen problems.

  Recruiting University of Miami · Miami, Florida · NCT01467869

• Registry for patients with spinal cord injuries in North America

  This study is collecting information from people who have had their first spinal cord injury to see how their treatment and recovery progress over the first year.

  Recruiting at 8 sites The Methodist Hospital Research Institute · Miami, Florida and 13 other locations · NCT00178724

NIH-funded research (newest 40 of 232)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Corticospinal neurons and recovery of precise forelimb movement after spinal cord injury

  This project studies how spine injuries change brain circuits and whether targeted rehabilitation helps restore precise forelimb movement.

  NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11628900

• How baclofen and spinal cord stimulation interact in people with spinal cord injury

  This study looks at how a common antispasmodic medicine (baclofen) works together with spinal cord stimulation in people who have spinal cord injuries and live with spasticity.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11625970

• Targeting spinal cord inflammation with a new HuR inhibitor to help SCI patients

  A new treatment approach uses a small molecule to block a brain-spinal inflammation regulator (HuR) that drives harmful inflammation after spinal cord injury, aiming to lessen damage and pain for people with SCI.

  NIH research Birmingham VA Medical Center · Birmingham, United States · NIH-11617294

• From Neural Control of Movement to Treatments for Spinal Cord Injury

  A patient-focused project aims to translate how brain signals control movement after spinal cord injury into new treatments that improve muscle function and reduce spasticity.

  NIH research Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · Chicago, United States · NIH-11605996

• Polaris: a compact system to help motor recovery after spinal cord injury and stroke

  A new, easy-to-use device called Polaris may help people with spinal cord injury, stroke, or other chronic conditions regain movement by guiding a specialized reflex-based therapy.

  NIH research Biocircuit Technologies, INC. · Atlanta, United States · NIH-11538499

• Predicting and Preventing Chronic Aspiration After Traumatic Cervical Spinal Cord Injury

  This project looks at swallowing problems and chronic aspiration in adults with traumatic neck spine injuries to find patterns that could prevent serious lung complications.

  NIH research University of Florida · Gainesville, United States · NIH-11509590

• Spinal cord neurons that help people stand after spinal cord injury

  This project will test whether activating specific spinal cord neurons can help adults with spinal cord injuries regain steady standing and posture.

  NIH research Northwestern University · Chicago, United States · NIH-11501932

• Understanding why oxycodone misuse may rise after spinal cord injury

  This project looks at why people with spinal cord injuries might be more prone to misusing opioids like oxycodone and how brain changes after such injuries could play a role.

  NIH research Drexel University · Philadelphia, United States · NIH-11465552

• Effects of activity-based recovery training on bladder and bowel function after spinal cord injury

  A study from University of Louisville explores noninvasive therapies to improve bladder and bowel function in people with spinal cord injury, including children and adults.

  NIH research University of Louisville · Louisville, United States · NIH-11450679

• Role of CPT1 activation in spinal cord injury

  This grant looks at how activating CPT1, a key enzyme in fat metabolism, may influence recovery after spinal cord injury in adults.

  NIH research Indiana University Indianapolis · Indianapolis, United States · NIH-11449353

• How blood flow affects gray matter loss after neck spinal cord injury

  This work looks at whether changing blood flow after a cervical (neck) spinal cord injury might protect gray matter and help recovery for people with these injuries.

  NIH research University of Louisville · Louisville, United States · NIH-11446855

• Blocking NOX4 to reduce muscle scarring after spinal cord injury

  A drug that blocks the NOX4 enzyme to lower muscle scarring and help people with spinal cord injuries regain muscle strength.

  NIH research Veterans Health Administration · Gainesville, United States · NIH-11446449

• Injectable hydrogel to help spinal cord injuries heal

  A scientist-led project is testing a special injectable gel that can deliver multiple therapeutic agents at once to a spinal cord injury, aiming to improve nerve growth and movement.

  NIH research Rowan University · Glassboro, United States · NIH-11445060

• Shockwave therapy to help reduce spasticity after spinal cord injury

  A randomized, sham-controlled trial will test whether extracorporeal shockwave therapy can lessen muscle tightness in people with spinal cord injuries.

  NIH research Kessler Foundation, INC. · East Hanover, UNITED STATES · NIH-11438642

• Mobile mindfulness app to help spinal cord injury patients manage chronic pain

  A widely available mindfulness app is being tested to help people with spinal cord injury reduce chronic pain and improve mood and daily functioning.

  NIH research Mayo Clinic Jacksonville · Jacksonville, United States · NIH-11438627

• Exploratory Trial of a modular, networked neurostimulation system to aid people with spinal cord injury

  A personalized, implantable neurostimulation system is being tested to help people with spinal cord injury improve multiple daily functions.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11424035

• Noninvasive genital nerve stimulation to help bladder control after spinal cord injury

  A new noninvasive device uses genital nerve stimulation to help women with spinal cord injury gain better bladder control and reduce leakage.

  NIH research Cleveland VA Medical Research/ed/fdn · Cleveland, United States · NIH-11423753

• Spinal Direct Current Stimulation to Improve Breathing After Cervical Cord Injury

  A non-invasive therapy using gentle electrical stimulation to help people with spinal cord injuries breathe better.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11416964

• Vagus nerve stimulation to help people walk again after spinal cord injury

  A new therapy combines targeted vagus nerve stimulation with walking-focused rehab to help people regain gait after spinal cord injury.

  NIH research University of Texas Dallas · Richardson, United States · NIH-11416268

• Personalized prediction of pressure sores after spinal cord injury

  This project will use body measures, muscle fat levels, and genetic information to predict which people with spinal cord injury are most likely to develop pressure sores so prevention can be personalized.

  NIH research Louis Stokes Cleveland VA Medical Center · Cleveland, United States · NIH-11415415

• Biomarkers that predict recovery after spinal cord injury in veterans

  We’re studying blood and body signals to help doctors predict how well veterans with spinal cord injuries might recover during rehab.

  NIH research Edward Hines Jr VA Hospital · Hines, United States · NIH-11412203

• Diaphragm nerve signals as a new path to better breathing after spinal cord injury

  A researcher at Marquette University is testing whether activating the nerve signals from the diaphragm can improve breathing after a cervical spinal cord injury.

  NIH research Marquette University · Milwaukee, United States · NIH-11395306

• Controlled PTEN reduction to help spinal cord nerves regrow after injury

  A scientist team is testing a way to safely reduce a growth-inhibiting protein (PTEN) in adults with spinal cord injury to help the nerves in the spinal cord regrow and restore movement.

  NIH research University of Louisville · Louisville, United States · NIH-11394619

• Non-invasive spinal stimulation to boost how the spine's sensorimotor network adapts after spinal cord injury

  A doctor-led study will test two non-invasive spinal stimulation methods to help people with spinal cord injury regain standing and movement.

  NIH research Methodist Hospital Research Institute · Houston, United States · NIH-11394527

• Targeted neuroplasticity with vagus nerve stimulation to help bladder problems after spinal cord injury

  A new approach uses vagus nerve stimulation paired with rehab to improve bladder function in people with spinal cord injury.

  NIH research Case Western Reserve University · Cleveland, United States · NIH-11393557

• Turning scar-forming support cells into neurons to repair spinal cord injuries

  This project uses a cell-reprogramming approach to make support cells into new nerve cells to help people with spinal cord injuries regain function.

  NIH research University of Louisville · Louisville, United States · NIH-11393167

• Protecting recovery after spinal cord injury from infection

  In people who have a spinal cord injury, getting a pneumonia-like infection may hinder recovery, and this grant studies how to prevent that harm.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11391394

• Understanding how age affects mitochondrial function in astrocytes after spinal cord injury

  This grant explores how aging changes mitochondria in brain-supporting cells after spinal cord injury and what that means for recovery.

  NIH research Texas A&m University Health Science Ctr · College Station, United States · NIH-11384375

• Autophagy in spinal cord injury and its effect on aging brain health

  This grant explores how the process of autophagy affects brain aging and dementia risk in people who have had spinal cord injuries.

  NIH research University of Maryland Baltimore · Baltimore, United States · NIH-11384098

• Overcoming Neurogenic Inflammation to Help Recovery After Spinal Cord Injury

  A long-term research project explores how spinal cord injury affects the body’s inflammation and metabolism, with the goal of improving health and recovery for adults with SCI.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11380635

• Stimulation-based strategies to build new spinal-cord connections and improve recovery after cervical injury

  Researchers are testing optogenetic spinal stimulation, alone and with a peptide, to help people (represented by this plan with rat data) recover movement after cervical spinal cord injuries.

  NIH research University of Washington · Seattle, United States · NIH-11378975

• Limb coordination during movement after spinal cord injury

  Researchers are testing how limbs coordinate during movement before and after spinal cord injury in a way that could help people regain smoother walking.

  NIH research Georgia Institute of Technology · Atlanta, United States · NIH-11378663

• Blocking ADAM17 to help nerves regrow after spinal cord injury

  Seeing if blocking a protein called ADAM17 can help nerves regrow after a spinal cord injury.

  NIH research Sloan-Kettering Inst Can Research · New York, United States · NIH-11374039

• Exploring how EphB2 and NMDA receptors drive pain after cervical spinal cord injury

  This project looks at a specific molecular interaction in the spinal cord that may contribute to chronic pain after neck-level spinal cord injuries, with the goal of finding new ways to help patients who have neuropathic pain.

  NIH research Thomas Jefferson University · Philadelphia, United States · NIH-11371153

• Understanding how CD44 and immune signals affect neural stem cells after spinal cord injury

  This grant studies how immune signals, including C1q, influence transplanted human neural stem cells after spinal cord injury to improve healing.

  NIH research University of California-Irvine · Irvine, United States · NIH-11370006

• SV2A PET imaging to track spinal cord injury recovery

  Researchers are testing a special brain/spinal cord scan called SV2A PET to see how spinal cord injuries change over time in people, using a new tracer to map nerve connections.

  NIH research Yale University · New Haven, United States · NIH-11367344

• Spinal cord stimulation to manage blood pressure after spinal cord injury

  A Mayo Clinic study will test how spinal cord stimulation affects blood pressure stability in people with spinal cord injury.

  NIH research Mayo Clinic Rochester · Rochester, United States · NIH-11366139

• Normobaric Oxygen Therapy to Protect Breathing After Spinal Cord Injury

  A study in people with cervical spinal cord injuries tests whether giving 100% oxygen at normal pressure right after injury can reduce inflammation and help preserve breathing.

  NIH research University of Florida · Gainesville, United States · NIH-11365957

• How aging affects spinal cord injury recovery through macrophage metabolism

  Aging may change how immune cells called macrophages work after spinal cord injury, and this grant tests a new approach to help recovery by tweaking their metabolism.

  NIH research University of Kentucky · Lexington, United States · NIH-11364068

• From Neural Control of Movement to Treatments for Spinal Cord Injury

  Aimed at people with spinal cord injury, this project builds on 15 years of research to strengthen brain and spinal pathways that control movement in order to improve recovery and reduce disability.

  NIH research Rehabilitation Institute of Chicago D/b/a Shirley Ryan Abilitylab · Chicago, United States · NIH-11359632

Related topics

Quick answers

How many Spinal Cord Injury clinical trials are recruiting right now?

98, as of November 12, 2026. 7 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 24 countries. The most sites are in United States (47 trials), Canada (11 trials), Switzerland (7 trials), France (6 trials), China (6 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 1: 5, Phase 1/2: 4, Early Phase 1: 3. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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