Enhancing memory through amygdala stimulation

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study investigates how direct electrical stimulation of the amygdala can enhance memory retention by modulating memory processes in the medial temporal lobe. It aims to understand the mechanisms by which the amygdala influences long-term memory, particularly in individuals with epilepsy who are undergoing monitoring for seizure localization. The research focuses on how emotional arousal and neuronal oscillations in the medial temporal lobe can support declarative memory. By exploring these connections, the study seeks to advance our understanding of memory function and develop new therapeutic approaches for memory disorders.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Must be able to understand and speak English.
* Able to provide informed consent.
* Diagnosed with epilepsy.
* Scheduled to undergo long-term intra-cranial video monitoring for seizure onset localization.
* Must be implanted with intracranial depth electrodes to the left or right amygdala, hippocampus, and parahippocampal/perirhinal cortices.

Exclusion Criteria:

* Unable to understand and speak English.
* Unable to provide informed consent.
* Not diagnosed with epilepsy.

Where it's running

• Washington University School of Medicine
  St Louis, Missouri, United States Recruiting

Study contacts

• Study coordinator: Joan Atencio
• Email: atencio@wustl.edu
• Phone: 314-362-3114

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Long-term outcomes after Hyperbaric Oxygen Therapy in veterans with TBI, PCS, or PTSD

  This study tests whether benefits from HBOT persist over time for veterans with brain injury or related conditions.

  Recruiting Phase 2 Summit Hyperbarics and Wellness · Boise, Idaho · NCT07732374

• Non‑trauma PTSD treatment for veterans and service members with mild or moderate TBI

  This pilot will test a non‑trauma psychotherapy program to help veterans and service members with mild or moderate traumatic brain injury who have PTSD.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Hood, Texas · NCT07351305

• Stimulating the motor thalamus and surface cortex to improve movement and speech

  This test tries brief electrical stimulation of the motor thalamus (VOP/VIM) and nearby cortex during DBS surgery to see if it improves movement, grip strength, and speech in people having DBS for Parkinson's disease, essential tremor, stroke, or brain injury.

  Recruiting University of Pittsburgh · Pittsburgh, Pennsylvania · NCT07056361

• Nutrition-based interventions to prevent cognitive decline

  This study is testing if a 6-month nutrition program can help adults at higher risk for dementia keep their thinking skills sharp.

  Recruiting at 2 sites Instituto de Saude Publica da Universidade do Porto · Porto, Portugal and 1 other locations · NCT06853405

• Rapid treatment for PTSD using brain stimulation

  This study is testing a quick brain stimulation treatment for people with PTSD to see if it can help reduce their symptoms in just one week.

  Recruiting Florida State University · Tallahassee, Florida · NCT06544408

• Improving sleep for Veterans with traumatic brain injury, PTSD, and chronic pain

  We will try morning bright light therapy at home to improve sleep for Veterans who have TBI, PTSD, and chronic pain.

  Recruiting VA Office of Research and Development · Portland, Oregon · NCT06477796

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.